Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies

Journal of Molecular Biology

Volumn 374, Issue 3, 2007, Pages 764-776

  Tidten, Naomi ^a   Stengl, Bernhard ^a   Heine, Andreas ^a   Garcia, George A ^b   Klebe, Gerhard ^a   Reuter, Klaus ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

induced fit; peptide flip; queuine; queuosine; tRNA modification

Indexed keywords

GLUTAMIC ACID; GLUTAMINE; GLYCOSYLTRANSFERASE; QUEUINE TRANSFER RIBONUCLEIC ACID RIBOSYLTRANSFERASE; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; ZYMOMONAS MOBILIS;

BACTERIA (MICROORGANISMS); ZYMOMONAS MOBILIS;

EID: 35548940243     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.09.062     Document Type: Article

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