Reversion and T cell escape mutations compensate the fitness loss of a CD8+ T cell escape mutant in their cognate transmitted/founder virus

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Song, Hongshuo ^a   Hora, Bhavna ^a   Bhattacharya, Tanmoy ^b,c   Goonetilleke, Nilu ^d   Liu, Michael K P ^d   Wiehe, Kevin ^a   Li, Hui ^e   Iyer, Shilpa S ^e   McMichael, Andrew J ^d   Perelson, Alan S ^b   Gao, Feng ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b LOS ALAMOS NATIONAL LABORATORY   (United States)

^c SANTA FE INSTITUTE   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; TRANSACTIVATOR PROTEIN; PRIMER DNA;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL KINETICS; CELL LOSS; CONTROLLED STUDY; DISEASE CONTROL; GROWTH RATE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NORMAL HUMAN; REVERTANT; T LYMPHOCYTE ESCAPE MUTATION; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS SURVIVAL; DNA SEQUENCE; ENZYME LINKED IMMUNOSPOT ASSAY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE EVASION; IMMUNOLOGY; MISSENSE MUTATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REPRODUCTIVE FITNESS; VIROLOGY;

BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; ENZYME-LINKED IMMUNOSPOT ASSAY; GENETIC FITNESS; GENOME, VIRAL; HIV-1; HUMANS; IMMUNE EVASION; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; SEQUENCE ANALYSIS, DNA; VIRUS REPLICATION;

EID: 84904318709     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102734     Document Type: Article

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