Early selection in gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

Journal of Virology

Volumn 84, Issue 22, 2010, Pages 11937-11949

  Brockman, Mark A ^a,b,c   Brumme, Zabrina L ^a,b,c   Brumme, Chanson J ^b,c   Miura, Toshiyuki ^c,d   Sela, Jennifer ^c   Rosato, Pamela C ^c   Kadie, Carl M ^e   Carlson, Jonathan M ^e   Markle, Tristan J ^a   Streeck, Hendrik ^c   Kelleher, Anthony D ^f   Markowitz, Martin ^g   Jessen, Heiko ^h   Rosenberg, Eric ^c   Altfeld, Marcus ^c,i   Harrigan, P Richard ^b   Heckerman, David ^e   Walker, Bruce D ^c,i,j   Allen, Todd M ^c,i  

^a SIMON FRASER UNIVERSITY   (Canada)

^b BRITISH COLUMBIA CENTRE FOR EXCELLENCE IN HIV AIDS   (Canada)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e MICROSOFT RESEARCH   (United States)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

^g AARON DIAMOND AIDS RESEARCH CENTER   (United States)

^h Jessen Praxis   (Germany)

ⁱ HARVARD UNIVERSITY   (United States)

^j HOWARD HUGHES MEDICAL INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; HLA B ANTIGEN; PROTEINASE;

ALLELE; ARTICLE; DNA POLYMORPHISM; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

ALLELES; CD4 LYMPHOCYTE COUNT; CHRONIC DISEASE; COHORT STUDIES; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV INFECTIONS; HIV-1; HLA-B ANTIGENS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 78049495989     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01086-10     Document Type: Article

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