메뉴 건너뛰기




Volumn 86, Issue 24, 2012, Pages 13423-13433

Intersubtype Differences in the effect of a rare p24 Gag mutation on HIV-1 replicative fitness

(21)  Chopera, Denis R a,b,c   Cotton, Laura A b   Zawaira, Alexander d   Mann, Jaclyn K e   Ngandu, Nobubelo K a   Ntale, Roman a   Carlson, Jonathan M f   Mlisana, Koleka g   Woodman, Zenda h   Rosa, Debra de Assis i   Martin, Eric b   Miura, Toshiyuki j   Pereyra, Florencia k   Walker, Bruce D k   Gray, Clive M h   Martin, Darren P a   Ndung'u, Thumbi e   Brockman, Mark A b,c   Karim, Salim Abdool g   Brumme, Zabrina L b,c   more..


Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CODON; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC DIFFERENCE; HLA TYPING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; MAJOR CLINICAL STUDY; NONHUMAN; P24 GAG GENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SITE DIRECTED MUTAGENESIS; VIRUS GENE; VIRUS LOAD; VIRUS MUTANT; VIRUS REPLICATION;

EID: 84870679723     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02171-12     Document Type: Article
Times cited : (10)

References (53)
  • 1
    • 66149154716 scopus 로고    scopus 로고
    • CCR5-and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic
    • Abraha A, et al. 2009. CCR5-and CXCR4-tropic subtype C human immunodeficiency virus type 1 isolates have a lower level of pathogenic fitness than other dominant group M subtypes: implications for the epidemic. J. Virol. 83:5592-5605.
    • (2009) J. Virol. , vol.83 , pp. 5592-5605
    • Abraha, A.1
  • 2
    • 43549111619 scopus 로고    scopus 로고
    • Crippling HIV one mutation at a time
    • Allen TM, Altfeld M. 2008. Crippling HIV one mutation at a time. J. Exp. Med. 205:1003-1007.
    • (2008) J. Exp. Med. , vol.205 , pp. 1003-1007
    • Allen, T.M.1    Altfeld, M.2
  • 3
    • 33749474469 scopus 로고    scopus 로고
    • Hitting HIV where it hurts: an alternative approach to HIV vaccine design
    • Altfeld M, Allen TM. 2006. Hitting HIV where it hurts: an alternative approach to HIV vaccine design. Trends Immunol. 27:504-510.
    • (2006) Trends Immunol. , vol.27 , pp. 504-510
    • Altfeld, M.1    Allen, T.M.2
  • 4
    • 69849087057 scopus 로고    scopus 로고
    • Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study
    • Avila-Rios S, et al. 2009. Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study. Retrovirology 6:72.
    • (2009) Retrovirology , vol.6 , pp. 72
    • Avila-Rios, S.1
  • 5
    • 33646701649 scopus 로고    scopus 로고
    • Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations
    • Bailey JR, Williams TM, Siliciano RF, Blankson JN. 2006. Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations. J. Exp. Med. 203:1357-1369.
    • (2006) J. Exp. Med. , vol.203 , pp. 1357-1369
    • Bailey, J.R.1    Williams, T.M.2    Siliciano, R.F.3    Blankson, J.N.4
  • 6
    • 62749167015 scopus 로고    scopus 로고
    • Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein
    • Boutwell CL, Rowley CF, Essex M. 2009. Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein. J. Virol. 83:2460-2468.
    • (2009) J. Virol. , vol.83 , pp. 2460-2468
    • Boutwell, C.L.1    Rowley, C.F.2    Essex, M.3
  • 7
    • 78049495989 scopus 로고    scopus 로고
    • Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection
    • Brockman MA, et al. 2010. Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection. J. Virol. 84:11937-11949.
    • (2010) J. Virol. , vol.84 , pp. 11937-11949
    • Brockman, M.A.1
  • 8
    • 36048995423 scopus 로고    scopus 로고
    • Escape and compensation from early HLAB57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A
    • Brockman MA, et al. 2007. Escape and compensation from early HLAB57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. J.Virol. 81:12608-12618.
    • (2007) J.Virol. , vol.81 , pp. 12608-12618
    • Brockman, M.A.1
  • 9
    • 30644465555 scopus 로고    scopus 로고
    • Use of a novel GFP reporter cell line to examine replication capacity of CXCR4-and CCR5-tropic HIV-1 by flow cytometry
    • Brockman MA, Tanzi GO, Walker BD, Allen TM. 2006. Use of a novel GFP reporter cell line to examine replication capacity of CXCR4-and CCR5-tropic HIV-1 by flow cytometry. J. Virol. Methods 131:134-142.
    • (2006) J. Virol. Methods , vol.131 , pp. 134-142
    • Brockman, M.A.1    Tanzi, G.O.2    Walker, B.D.3    Allen, T.M.4
  • 10
    • 68949209789 scopus 로고    scopus 로고
    • HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol, and Nef proteins
    • doi: 10.1371/journal.pone.0006687
    • Brumme ZL, et al. 2009. HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol, and Nef proteins. PLoS One 4:e6687. doi: 10.1371/journal.pone.0006687.
    • (2009) PLoS One , vol.4
    • Brumme, Z.L.1
  • 11
    • 78751640260 scopus 로고    scopus 로고
    • Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers
    • Brumme ZL, et al. 2011. Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers. J. Acquir. Immune Defic. Syndr. 56:100-108.
    • (2011) J. Acquir. Immune Defic. Syndr. , vol.56 , pp. 100-108
    • Brumme, Z.L.1
  • 12
    • 67449168410 scopus 로고    scopus 로고
    • Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification
    • Brumme ZL, Walker BD. 2009. Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification. J. Exp. Med. 206:1215-1218.
    • (2009) J. Exp. Med. , vol.206 , pp. 1215-1218
    • Brumme, Z.L.1    Walker, B.D.2
  • 13
    • 34648824673 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications
    • Buonaguro L, Tornesello ML, Buonaguro FM. 2007. Human immunodeficiency virus type 1 subtype distribution in the worldwide epidemic: pathogenetic and therapeutic implications. J. Virol. 81:10209-10219.
    • (2007) J. Virol. , vol.81 , pp. 10209-10219
    • Buonaguro, L.1    Tornesello, M.L.2    Buonaguro, F.M.3
  • 14
    • 57149090493 scopus 로고    scopus 로고
    • Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag
    • doi:10.1371/journal.pcbi.1000225
    • Carlson JM, et al. 2008. Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput. Biol. 4:e1000225. doi:10.1371/journal.pcbi.1000225.
    • (2008) PLoS Comput. Biol. , vol.4
    • Carlson, J.M.1
  • 15
    • 84861325273 scopus 로고    scopus 로고
    • Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
    • Carlson JM, et al. 2012. Widespread impact of HLA restriction on immune control and escape pathways of HIV-1. J. Virol. 86:5230-5243.
    • (2012) J. Virol. , vol.86 , pp. 5230-5243
    • Carlson, J.M.1
  • 16
    • 79960408057 scopus 로고    scopus 로고
    • Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals
    • Chopera DR, et al. 2011. Virological and immunological factors associated with HIV-1 differential disease progression in HLA-B 58:01-positive individuals. J. Virol. 85:7070-7080.
    • (2011) J. Virol. , vol.85 , pp. 7070-7080
    • Chopera, D.R.1
  • 17
    • 42949092720 scopus 로고    scopus 로고
    • Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
    • doi:10.1371/journal.ppat.1000033
    • Chopera DR, et al. 2008. Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. PLoS Pathog. 4:e1000033. doi:10.1371/journal.ppat.1000033.
    • (2008) PLoS Pathog , vol.4
    • Chopera, D.R.1
  • 19
    • 84863599412 scopus 로고    scopus 로고
    • HLA class I sequence-based typing using DNA recovered from frozen plasma
    • Cotton LA, et al. 2012. HLA class I sequence-based typing using DNA recovered from frozen plasma. J. Immunol. Methods 382:40-47.
    • (2012) J. Immunol. Methods , vol.382 , pp. 40-47
    • Cotton, L.A.1
  • 20
    • 59649120492 scopus 로고    scopus 로고
    • Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1
    • Coutsinos D, et al. 2009. Template usage is responsible for the preferential acquisition of the K65R reverse transcriptase mutation in subtype C variants of human immunodeficiency virus type 1. J. Virol. 83:2029-2033.
    • (2009) J. Virol. , vol.83 , pp. 2029-2033
    • Coutsinos, D.1
  • 21
    • 85047684409 scopus 로고    scopus 로고
    • Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients
    • Crawford H, et al. 2009. Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients. J. Exp. Med. 206:909-921.
    • (2009) J. Exp. Med. , vol.206 , pp. 909-921
    • Crawford, H.1
  • 22
    • 34547138161 scopus 로고    scopus 로고
    • Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    • Crawford H, et al. 2007. Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection. J. Virol. 81:8346-8351.
    • (2007) J. Virol. , vol.81 , pp. 8346-8351
    • Crawford, H.1
  • 23
    • 0030448994 scopus 로고    scopus 로고
    • Crystal structure of human cyclophilin A bound o the amino-terminal domain of HIV-1 capsid
    • Gamble TR, et al. 1996. Crystal structure of human cyclophilin A bound o the amino-terminal domain of HIV-1 capsid. Cell 87:1285-1294.
    • (1996) Cell , vol.87 , pp. 1285-1294
    • Gamble, T.R.1
  • 24
    • 33644865927 scopus 로고    scopus 로고
    • Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop
    • Gatanaga H, et al. 2006. Altered HIV-1 Gag protein interactions with cyclophilin A (CypA) on the acquisition of H219Q and H219P substitutions in the CypA binding loop. J. Biol. Chem. 281:1241-1250.
    • (2006) J. Biol. Chem. , vol.281 , pp. 1241-1250
    • Gatanaga, H.1
  • 25
    • 77952774582 scopus 로고    scopus 로고
    • Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs
    • John M, et al. 2010. Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs. J. Immunol. 184:4368-4377.
    • (2010) J. Immunol. , vol.184 , pp. 4368-4377
    • John, M.1
  • 26
    • 10644267588 scopus 로고    scopus 로고
    • Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
    • Kiepiela P, et al. 2004. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature 432:769-775.
    • (2004) Nature , vol.432 , pp. 769-775
    • Kiepiela, P.1
  • 27
    • 40149089453 scopus 로고    scopus 로고
    • Statistical resolution of ambiguous HLA typing data
    • doi:10.1371/journal.pcbi.1000016
    • Listgarten J, et al. 2008. Statistical resolution of ambiguous HLA typing data. PLoS Comput. Biol. 4:e1000016. doi:10.1371/journal.pcbi.1000016.
    • (2008) PLoS Comput. Biol. , vol.4
    • Listgarten, J.1
  • 28
    • 33645240933 scopus 로고    scopus 로고
    • Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    • Martinez-Picado J, et al. 2006. Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J. Virol. 80:3617-3623.
    • (2006) J. Virol. , vol.80 , pp. 3617-3623
    • Martinez-Picado, J.1
  • 29
    • 67849130555 scopus 로고    scopus 로고
    • PEP-FOLD: an online resource for de novo peptide structure prediction
    • Maupetit J, Derreumaux P, Tuffery P. 2009. PEP-FOLD: an online resource for de novo peptide structure prediction. Nucleic Acids Res. 37: W498-W503.
    • (2009) Nucleic Acids Res. , vol.37
    • Maupetit, J.1    Derreumaux, P.2    Tuffery, P.3
  • 30
    • 0034044314 scopus 로고    scopus 로고
    • The PSIPRED protein structure prediction server
    • McGuffin LJ, Bryson K, Jones DT. 2000. The PSIPRED protein structure prediction server. Bioinformatics 16:404-405.
    • (2000) Bioinformatics , vol.16 , pp. 404-405
    • Mcguffin, L.J.1    Bryson, K.2    Jones, D.T.3
  • 31
    • 50149101954 scopus 로고    scopus 로고
    • Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    • Miura T, et al. 2008. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J. Virol. 82:8422-8430.
    • (2008) J. Virol. , vol.82 , pp. 8422-8430
    • Miura, T.1
  • 32
    • 58149398654 scopus 로고    scopus 로고
    • HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1
    • Miura T, et al. 2009. HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1. J. Virol. 83:140-149.
    • (2009) J. Virol. , vol.83 , pp. 140-149
    • Miura, T.1
  • 33
    • 62749177486 scopus 로고    scopus 로고
    • HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition
    • Miura T, et al. 2009. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition. J. Virol. 83:2743-2755.
    • (2009) J. Virol. , vol.83 , pp. 2743-2755
    • Miura, T.1
  • 34
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • Pereyra F, et al. 2008. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J. Infect. Dis. 197:563-571.
    • (2008) J. Infect. Dis. , vol.197 , pp. 563-571
    • Pereyra, F.1
  • 35
    • 0030977113 scopus 로고    scopus 로고
    • Quantitation of target molecules from polymerase chain reaction-based limiting dilution assays
    • Rodrigo AG, et al. 1997. Quantitation of target molecules from polymerase chain reaction-based limiting dilution assays. AIDS Res. Hum. Retroviruses 13:737-742.
    • (1997) AIDS Res. Hum. Retroviruses , vol.13 , pp. 737-742
    • Rodrigo, A.G.1
  • 36
    • 77958587523 scopus 로고    scopus 로고
    • Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics
    • doi:10.1371/journal.pone.0012463
    • Rolland M, et al. 2010. Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics. PLoS One 5:e12463. doi:10.1371/journal.pone.0012463.
    • (2010) PLoS One , vol.5 , pp. 12463
    • Rolland, M.1
  • 37
    • 45749104088 scopus 로고    scopus 로고
    • HLA class-I driven evolution of human immunodeficiency virus type 1 subtype C proteome: immune escape and viral load
    • Rousseau CM, et al. 2008. HLA class-I driven evolution of human immunodeficiency virus type 1 subtype C proteome: immune escape and viral load. J. Virol. 82:6434-6446.
    • (2008) J. Virol. , vol.82 , pp. 6434-6446
    • Rousseau, C.M.1
  • 38
    • 84855278211 scopus 로고    scopus 로고
    • HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency
    • doi:10.1371/journal.ppat.1002439
    • Schaller T, et al. 2011. HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathog. 7:e1002439. doi:10.1371/journal.ppat.1002439.
    • (2011) PLoS Pathog , vol.7 , pp. 1002439
    • Schaller, T.1
  • 39
    • 43949094512 scopus 로고    scopus 로고
    • Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid
    • Schneidewind A, et al. 2008. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J. Virol. 82:5594-5605.
    • (2008) J. Virol. , vol.82 , pp. 5594-5605
    • Schneidewind, A.1
  • 40
    • 36048949732 scopus 로고    scopus 로고
    • Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    • Schneidewind A, et al. 2007. Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J. Virol. 81:12382-12393.
    • (2007) J. Virol. , vol.81 , pp. 12382-12393
    • Schneidewind, A.1
  • 41
    • 73949099485 scopus 로고    scopus 로고
    • Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage
    • Soares EA, et al. 2009. Mutation T74S in HIV-1 subtype B and C proteases resensitizes them to ritonavir and indinavir and confers fitness advantage. J. Antimicrob. Chemother. 64:938-944.
    • (2009) J. Antimicrob. Chemother. , vol.64 , pp. 938-944
    • Soares, E.A.1
  • 42
    • 8644286696 scopus 로고    scopus 로고
    • Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity
    • Sokolskaja E, Sayah DM, Luban J. 2004. Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity. J. Virol. 78: 12800-12808.
    • (2004) J. Virol. , vol.78 , pp. 12800-12808
    • Sokolskaja, E.1    Sayah, D.M.2    Luban, J.3
  • 44
    • 0036294666 scopus 로고    scopus 로고
    • Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein
    • Tang C, Ndassa Y, Summers MF. 2002. Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein. Nat. Struct. Biol. 9:537-543.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 537-543
    • Tang, C.1    Ndassa, Y.2    Summers, M.F.3
  • 45
    • 55249105920 scopus 로고    scopus 로고
    • The challenge of HIV-1 subtype diversity
    • Taylor BS, Hammer SM. 2008. The challenge of HIV-1 subtype diversity. N. Engl. J. Med. 359:1965-1966.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1965-1966
    • Taylor, B.S.1    Hammer, S.M.2
  • 46
    • 84864452901 scopus 로고    scopus 로고
    • PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides
    • Thevenet P, et al. 2012. PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides. Nucleic Acids Res. 40:W288-W293.
    • (2012) Nucleic Acids Res. , vol.40
    • Thevenet, P.1
  • 47
    • 0027968068 scopus 로고
    • CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, Gibson TJ. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 48
    • 44849132669 scopus 로고    scopus 로고
    • Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study
    • doi:10.1371/journal. pone.0001954
    • van Loggerenberg F, et al. 2008. Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study. PLoS One 3:e1954. doi:10.1371/journal. pone.0001954.
    • (2008) PLoS One , vol.3 , pp. 1954
    • van Loggerenberg, F.1
  • 49
    • 77957194223 scopus 로고    scopus 로고
    • Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters
    • Wright J, et al. 2010. Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. J. Virol. 84:10820-10831.
    • (2010) J. Virol. , vol.84 , pp. 10820-10831
    • Wright, J.1
  • 50
    • 84857936999 scopus 로고    scopus 로고
    • Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity
    • Wright JK, et al. 2012. Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacity. J. Virol. 86:3193-3199.
    • (2012) J. Virol. , vol.86 , pp. 3193-3199
    • Wright, J.K.1
  • 51
    • 79952846443 scopus 로고    scopus 로고
    • Influence of gag-protease-mediated replication capacity on disease progression in individuals recently, infected with HIV-1 subtype C
    • Wright JK, et al. 2011. Influence of gag-protease-mediated replication capacity on disease progression in individuals recently, infected with HIV-1 subtype C. J. Virol. 85:3996-4006.
    • (2011) J. Virol. , vol.85 , pp. 3996-4006
    • Wright, J.K.1
  • 52
    • 61549120158 scopus 로고    scopus 로고
    • Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance
    • Xu HT, et al. 2009. Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance. Retrovirology 6:14.
    • (2009) Retrovirology , vol.6 , pp. 14
    • Xu, H.T.1
  • 53
    • 84870708941 scopus 로고    scopus 로고
    • HIV molecular immunology. Publication LA-UR 09-05941
    • Theoretical Biology and Biophysics, Los Alamos, NM
    • Yusim K, et al. 2009. HIV molecular immunology. Publication LA-UR 09-05941. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, NM.
    • (2009) Los Alamos National Laboratory
    • Yusim, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.