Studies towards biocompatibility of PAMAM dendrimers - Overall hemostasis potential and integrity of the human aortic endothelial barrier

International Journal of Pharmaceutics

Volumn 473, Issue 1-2, 2014, Pages 158-169

  Markowicz Piasecka, Magdalena ^a   Łuczak, Emilia ^a   Chałubiński, Maciej ^a   Broncel, Marlena ^a   Mikiciuk Olasik, Elzbieta ^a   Sikora, Joanna ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

Clot formation; Coagulation; Endothelium; Fibrinolysis; Nanotechnology; PAMAM dendrimers

Indexed keywords

DENDRIMER; DEXTRO PHENYLALANYLPIPECOLYLARGININE 4 NITROANILIDE; FIBRINOGEN; POLYAMIDOAMINE; THROMBIN; PAMAM STARBURST;

AORTIC ENDOTHELIAL BARRIER; ARTICLE; BIOCOMPATIBILITY; BLOOD CLOTTING; BLOOD CLOTTING TIME; CONTROLLED STUDY; ENZYME ACTIVITY; FIBRINOLYSIS; HEMOSTASIS; HUMAN; HUMAN CELL; IMPEDANCE; MICROSCOPY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; THROMBIN TIME; VASCULAR ENDOTHELIUM; AORTA; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM;

AORTA; BLOOD COAGULATION; CELLS, CULTURED; DENDRIMERS; ENDOTHELIAL CELLS; HEMOSTASIS; HUMANS; THROMBIN;

EID: 84904281364     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.07.002     Document Type: Article

References (54)

1. H.B. Agashe, T.D. Dutta, M. Garg, and N.K. Jain Investigations on the toxicological profile of functionalized fifth-generation poly(propylene imine) dendrimer J. Pharm. Pharmacol. 58 2006 1491 1498 (Pubitemid 44785538)
2. H. Ait-Oufella, E. Maury, S. Lehoux, B. Guidet, and G. Offenstadt The endothelium: physiological functions and role in microcirculatory failure during severe skepsis Intens. Care Med. 36 2010 1286 1298
3. A. Antovic The overall hemostasis potential: a laboratory tool for the investigation of global hemostasis Sem. Thromb. Hem. 36 2010 772 779
4. R. Ariens, H. Kohler, M. Mansfield, and P. Grant Subunit antigen and activity levels of blood coagulation factor XIII in healthy individuals: relation to sex, age, smoking and hypertension Arterioscler. Thromb. Vasc. Biol. 19 1999 2012 2016 (Pubitemid 29379937)
5. W.E. Bawarski, E. Chidlowsky, D.J. Bharali, and S.A. Mousa Emerging nanopharmaceuticals Nanomed. Nanotechnol. Biol. Med. 4 2008 273 282
6. G. Caminati, N.J. Turro, and D.A. Tomalia Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants J. Am. Chem. Soc. 112 1999 8515 8522
7. M. Chalubinski, K. Zemanek, W. Skowron, K. Wojdan, P. Gorzelak, and M. Broncel The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers Inflamm. Res. 62 2013 1015 1023
8. H.T. Chen, M.F. Neerman, A.R. Parrish, and E. Simanek Cytotoxicity, haemolysis, and acute in vivo toxicity of dendrimer based on melamine, candidate vehicles for drug delivery J. Am. Chem. Soc. 126 2004 10044 10048 (Pubitemid 39079425)
9. M.A. Dobrovolskaia, A.K. Patri, J. Simak, J.B. Hall, J. Semberova, S.H. de Paoli Lacerda, and S.E. McNeil Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro Mol. Pharm. 9 2012 382 393
10. R. Duncan Polymer therapeutics as nanomedicines: new perspectives Curr. Opin. Biotechol. 22 2011 1 10
11. R. Duncan, and L. Izzo Dendrimer biocompatibility and toxicity Adv. Drug Deliv. Rev. 57 2005 2215 2237 (Pubitemid 41759394)
12. E. Durán-Lara, L. Guzmán, A. John, E. Fuentes, M. Alarcón, I. Palomo, and L.S. Santos PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy Eur. J. Med. Chem. 69 2013 601 608
13. J. Drzewińska, D. Appelhans, B. Voit, M. Bryszewska, and B. Klajnert Poly(propylene imine) dendrimers modified with maltose or maltotriose protect phosphorothioate oligodeoxynucleotides against nuclease activity Biochem. Biophys. Res. Commun. 427 2012 197 201
14. M. El-Sayed, M.F. Kiani, M.D. Naimark, A.H. Hikal, and H. Ghandehari Extravasation of poly(amidoamine) (PAMAM) dendrimers cross microvascular network endothelium Pharm. Res. 18 2001 23 28 (Pubitemid 32299618)
15. M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers J. Control. Release 81 2002 355 365 (Pubitemid 34607155)
16. M. Fischer, and F. Vögtle Dendrimers: from design to application - a progress report Angew. Chem. Int. Edn. 38 1999 884 905 (Pubitemid 29180954)
17. D. Glover, and E. Warner The CLUE test. A multiparameter coagulation and fibrinolysis screening test using the platelet aggregometer Am. J. Clin. Pathol. 63 1975 74 80
18. K. Greish, G. Thiagarajan, H. Herd, R. Price, H. Bauer, D. Hubbard, A. Burckle, S. Sadekar, T. Yu, A. Anwar, A. Ray, and H. Ghandehari Size and surface charge significantly influence toxicity of silica and dendritic nanoparticles Nanotoxiciology 6 2011 713 723
19. I. Haletsa, D. Shcharbina, B. Klajnert, and M. Bryszewska Contribution of hydrophobicity, DNA and proteins to the cytotoxicity of cationic PAMAM dendrimers Int. J. Pharmacol. 454 2013 1 3
20. S. He, K. Bremme, and M. Blombäck A laboratory method for determination of overall haemostatic potential in plasma. I. Method design and preliminary results Thromb. Res. 96 1999 145 156 (Pubitemid 29502215)
21. S. He, A. Antovic, and M. Blombäck A simple and rapid laboratory method for determination of hemostasis potential in plasma. II. Modifications for use in routine laboratories and research work Thromb. Res. 103 2001 355 361 (Pubitemid 32831470)
22. K. Jain, P. Kesharwani, U. Gupta, and N.K. Jain Dendrimer toxicity: let's meet the challenge Int. J. Pharm. 394 2010 122 142
23. W.D. Jang, K.M. Kamruzzaman, C.H. Lee, and I.K. Kang Bioinspired application of dendrimers: from bio-mimicry to biomedical applications Prog. Polym. Sci. 34 2009 1 23
24. R. Jevprasesphant, J. Penny, R. Jalal, D. Attwood, N.B. McKeown, and A. D'Emanuele The influence of surface modification on the cytotoxicity of PAMAM dendrimers Int. J. Pharm. 252 2003 263 266 (Pubitemid 36126635)
25. V. Johari, and C. Loke Brief overview of the coagulation cascade Dis. Mon. 58 2012 421 423
26. C.F. Jones, R.A. Campbell, A.E. Brooks, S. Assemi, S. Tadjiki, G. Thiagarajan, C. Mulcock, A.S. Weyrich, B.D. Brooks, H. Ghandehari, and D.W. Grainger Cationic PAMAM dendrimers aggressively initiate blood clot formation ACS Nano 6 2012 9900 9910
27. C.F. Jones, R.A. Campbell, Z. Franks, C.C. Gibson, G. Thiagarajan, A. Vieira-de-Abreu, S. Sukavaneshvar, S.F. Mohammad, D.Y. Li, H. Ghandehari, A.S. Weyrich, B.D. Brooks, and D.W. Grainger Cationic PAMAM dendrimers disrupt key platelet functions Mol. Pharm. 9 2012 1599 1611
28. C. Kermisch Do new ethical issues arise at each stage of nanotechnological development? Nanoethics 6 2012 29 37
29. P. Kesharwani, K. Jain, and N.K. Jain Dendrimer as nanocarrier for drug delivery Prog. Polym. Sci. 2013 http://dx.doi.org/10.1016/j.progpolymsci.2013. 07.005
30. D. Khang, J. Carpenter, Y.W. Chun, R. Pareta, and T.J. Webster Nanotechnology for regenerative medicine Biomed. Microdevices 12 2010 575 587
31. R.B. Kolhatkar, K.M. Kitchens, P.W. Swaan, and H. Ghandehari Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability Bioconjugate Chem. 18 2007 2054 2060 (Pubitemid 350220008)
32. B. Kostka, J. Para, and J. Sikora A multiparameter test of clot formation and fibrynolysis for in-vitro drug screening Blood Coagul. Fibrin. 18 2007 611 618 (Pubitemid 47479410)
33. A. Kunzmann, B. Andersson, T. Thurnherr, H. Krug, A. Scheynius, and B. Fadeel Toxicology of engineered nanomaterials: focus on biocompatibility, biodistribution and biodegradation Biochim. Biophys. Acta 1810 2011 361 373
34. L.N. Lin, Q. Liu, L. Song, F.F. Liu, and J.X. Sha Recent advances in nanotechnology based drug delivery to the brain Cytotechnology 62 2010 377 380
35. Z. Liu, Y. Jiao, T. Wang, Y. Zhang, and W. Xue Interactions between solubilized polymer molecules and blood components J. Contr. Release 30 2012 14 24
36. Ch-Ch. Lo, H.Ch. Wang, P.Y. Chien, and W.Ch. Hung An empirical study of commercialization performance on nanoproducts Technovation 32 2012 168 178
37. R. Lottenberg, J.A. Hall, J.W. Fenton, and C.M. Jackson The action of thrombin on peptide p-nitroanilide substrates: hydrolysis of Tos-Gly-Pro-Arg-pNA and d-Phe-Pip-Arg-pNA by human alpha and gamma and bovine alpha and beta-thrombins Thromb. Res. 28 1982 313 332 (Pubitemid 13254965)
38. V. Mangematin, and S. Walsh The future of nanotechnologies Technovation 32 2012 157 160
39. M. Markowicz, P. Szymański, M. Ciszewski, A. Kłys, and E. Mikiciuk-Olasik Evaluation of poly(amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy J. Biol. Phys. 38 2012 637 656
40. S.R. Mudshinge, A.B. Deore, S. Patil, and C.M. Bhalgat Nanoparticles: emerging carriers for drug delivery Saudi Pharm. J. 19 2011 129 141
41. S.P. Mukherjee, M. Davoren, and H.J. Byrne In vitro mammalian cytotoxicological study of PAMAM dendrimers-towards quantitative structure activity relationships Toxicol. In Vitro 24 2010 169 177
42. P.C. Naha, M. Davoren, F.M. Lyng, and H.J. Byrne Reactive oxygen species (ROS) induced cytokine production and cytotoxicity of PAMAM dendrimers in J774A. 1 cells Toxicol. Appl. Pharm. 246 2010 91 99
43. A.M. Naylor, and W.A. Goddard Starburst dendrimers. 5. Molecular shape control J. Am. Chem. Soc. 111 1989 2339 2341
44. S. Parveen, R. Misra, and S.K. Sahoo Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging Nanomed. Nanotechnol 8 2012 147 166
45. A.R. Pries The vascular endothelum: structural, functional and pathophysiological aspects Biomed. Pharmacother. 62 2008 503 512
46. J.C. Roberts, M.K. Bhalgat, and R.T. Zera Preliminary biological evaluation of polyamidoamine (PAMAM) starburst dendrimers J. Biomed. Mater. Res. 30 1996 53 65
47. A. Rutherford Haemostasis and disseminated intravascular coagulation Int. Congr. Ser. 12 1996 161 167
48. S. Sadekara, G. Thiagarajanb, K. Bartlett, D. Hubbard, A. Raya, L. McGilld, and H. Ghandehari Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin Int. J. Pharmacol. 456 2013 175 185
49. J. Sikora, M. Broncel, M. Markowicz, M. Chałubiński, K. Wojdan, and E. Mikiciuk-Olasik Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome Eur. J. Nutr. 51 2012 549 556
50. N.A. Stasko, J.C. Bryce, M.H. Schoenfisch, T.A. Johnson, and E.L. Holmuhamedov Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells Biomacromolecules 8 2007 3853 3859
51. P. Szymański, M. Markowicz, and E. Mikiciuk-Olasik Nanotechnology in pharmaceutical and biomedical applications: dendrimers NANO Brief. Rep. Rev. 6 2011 509 539
52. J.P. Walsh, and C. Ridge Knowledge production and nanotechnology: characterizing American dissertation research, 1999-2009 Technol. Soc. 34 2012 127 137
53. V.W.M. Van Hinsbergh Endothelial permeability for macromolecules. Mechanistic aspects of pathophysiological modulation Arterioscler. Thromb. Vasc. Biol. 17 1997 1018 1023 (Pubitemid 27260318)
54. Wang, X., 2009. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays. US 7560269 B2.