메뉴 건너뛰기




Volumn 34, Issue 2, 2014, Pages 592-598

Axl receptor tyrosine kinase is a novel target of apigenin for the inhibition of cell proliferation

Author keywords

Apigenin; Axl; Lung cancer; p21; X linked inhibitor of apoptosis

Indexed keywords

APIGENIN; AXL RECEPTOR TYROSINE KINASE; PROTEIN P21; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; ONCOPROTEIN; P21 ACTIVATED KINASE; XIAP PROTEIN, HUMAN;

EID: 84904268487     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2014.1804     Document Type: Article
Times cited : (17)

References (45)
  • 1
    • 70449920907 scopus 로고    scopus 로고
    • Neuroprotective effects of apigenin on acute transient focal cerebral ischemia-reperfusion injury in rats
    • In Chinese
    • Liu C, Tu FX and Chen X: Neuroprotective effects of apigenin on acute transient focal cerebral ischemia-reperfusion injury in rats. Zhong Yao Cai 31: 870-873, 2008 (In Chinese).
    • (2008) Zhong Yao Cai , vol.31 , pp. 870-873
    • Liu, C.1    Tu, F.X.2    Chen, X.3
  • 2
    • 4544274945 scopus 로고    scopus 로고
    • Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert)
    • DOI 10.1016/j.phytochem.2004.07.011, PII S0031942204003486
    • Svehliková V, Bennett RN, Mellon FA, et al: Isolation, identification and stability of acylated derivatives of apigenin 7-O-glucoside from chamomile (Chamomilla recutita [L.] Rauschert). Phytochemistry 65: 2323-2332, 2004. (Pubitemid 39237248)
    • (2004) Phytochemistry , vol.65 , Issue.16 , pp. 2323-2332
    • Svehlikova, V.1    Bennett, R.N.2    Mellon, F.A.3    Needs, P.W.4    Piacente, S.5    Kroon, P.A.6    Bao, Y.7
  • 3
    • 0034807826 scopus 로고    scopus 로고
    • Dietary agents in cancer prevention: Flavonoids and isoflavonoids
    • DOI 10.1016/S0163-7258(01)00137-1, PII S0163725801001371
    • Birt DF, Hendrich S and Wang W: Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90: 157-177, 2001. (Pubitemid 32913477)
    • (2001) Pharmacology and Therapeutics , vol.90 , Issue.2-3 , pp. 157-177
    • Birt, D.F.1    Hendrich, S.2    Wang, W.3
  • 4
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3: 768-780, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 6
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • DOI 10.1146/annurev.nutr.21.1.381
    • Yang CS, Landau JM, Huang MT and Newmark HL: Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 21: 381-406, 2001. (Pubitemid 32695277)
    • (2001) Annual Review of Nutrition , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.-T.3    Newmark, H.L.4
  • 7
    • 4644365733 scopus 로고    scopus 로고
    • Identification of compounds in wine by HPLC-tandem mass spectrometry
    • DOI 10.1002/adic.200490085
    • Bevilacqua L, Buiarelli F, Coccioli F and Jasionowska R: Identification of compounds in wine by HPLC-tandem mass spectrometry. Ann Chim 94: 679-689, 2004. (Pubitemid 39297619)
    • (2004) Annali di Chimica , vol.94 , Issue.9-10 , pp. 679-689
    • Bevilacqua, L.1    Buiarelli, F.2    Coccioli, F.3    Jasionowska, R.4
  • 8
    • 12744276051 scopus 로고    scopus 로고
    • Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells
    • Zheng PW, Chiang LC and Lin CC: Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. Life Sci 76: 1367-1379, 2005.
    • (2005) Life Sci , vol.76 , pp. 1367-1379
    • Zheng, P.W.1    Chiang, L.C.2    Lin, C.C.3
  • 9
    • 79960752022 scopus 로고    scopus 로고
    • Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways
    • Lu HF, Chie YJ, Yang MS, et al: Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways. Hum Exp Toxicol 30: 1053-1061, 2011.
    • (2011) Hum Exp Toxicol , vol.30 , pp. 1053-1061
    • Lu, H.F.1    Chie, Y.J.2    Yang, M.S.3
  • 10
    • 78649635941 scopus 로고    scopus 로고
    • Molecular targets of apigenin in colorectal cancer cells: Involvement of p21, NAG-1 and p53
    • Zhong Y, Krisanapun C, Lee SH, et al: Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. Eur J Cancer 46: 3365-3374, 2010.
    • (2010) Eur J Cancer , vol.46 , pp. 3365-3374
    • Zhong, Y.1    Krisanapun, C.2    Lee, S.H.3
  • 12
    • 67349195756 scopus 로고    scopus 로고
    • Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1
    • Li ZD, Hu XW, Wang YT and Fang J: Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1. FEBS Lett 583: 1999-2003, 2009.
    • (2009) FEBS Lett , vol.583 , pp. 1999-2003
    • Li, Z.D.1    Hu, X.W.2    Wang, Y.T.3    Fang, J.4
  • 13
    • 34547114744 scopus 로고    scopus 로고
    • Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice
    • DOI 10.1158/0008-5472.CAN-07-0717
    • Shukla S, MacLennan GT, Flask CA, et al: Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res 67: 6925-6935, 2007. (Pubitemid 47105540)
    • (2007) Cancer Research , vol.67 , Issue.14 , pp. 6925-6935
    • Shukla, S.1    MacLennan, G.T.2    Flask, C.A.3    Fu, P.4    Mishra, A.5    Resnick, M.I.6    Gupta, S.7
  • 14
    • 23944521126 scopus 로고    scopus 로고
    • Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: Implication of chemoprevention of lung cancer
    • DOI 10.1124/mol.105.011254
    • Liu LZ, Fang J, Zhou Q, Hu X, Shi X and Jiang BH: Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer. Mol Pharmacol 68: 635-643, 2005. (Pubitemid 41206017)
    • (2005) Molecular Pharmacology , vol.68 , Issue.3 , pp. 635-643
    • Liu, L.-Z.1    Fang, J.2    Zhou, Q.3    Hu, X.4    Shi, X.5    Jiang, B.-H.6
  • 15
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • DOI 10.1096/fj.04-2175com
    • Fang J, Xia C, Cao Z, Zheng JZ, Reed E and Jiang BH: Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J 19: 342-353, 2005. (Pubitemid 40316522)
    • (2005) FASEB Journal , vol.19 , Issue.3 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.-H.6
  • 16
    • 50249087534 scopus 로고    scopus 로고
    • Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells
    • Mirzoeva S, Kim ND, Chiu K, Franzen CA, Bergan RC and Pelling JC: Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells. Mol Carcinog 47: 686-700, 2008.
    • (2008) Mol Carcinog , vol.47 , pp. 686-700
    • Mirzoeva, S.1    Kim, N.D.2    Chiu, K.3    Franzen, C.A.4    Bergan, R.C.5    Pelling, J.C.6
  • 19
    • 0032820867 scopus 로고    scopus 로고
    • Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): Results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)
    • Rochlitz C, Lohri A, Bacchi M, et al: Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK). Leukemia 13: 1352-1358, 1999. (Pubitemid 29429761)
    • (1999) Leukemia , vol.13 , Issue.9 , pp. 1352-1358
    • Rochlitz, C.1    Lohri, A.2    Bacchi, M.3    Schmidt, M.4    Nagel, S.5    Fopp, M.6    Fey, M.F.7    Herrmann, R.8    Neubauer, A.9
  • 20
    • 0034957362 scopus 로고    scopus 로고
    • Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast
    • DOI 10.1023/A:1011126330233
    • Berclaz G, Altermatt HJ, Rohrbach V, Kieffer I, Dreher E and Andres AC: Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast. Ann Oncol 12: 819-824, 2001. (Pubitemid 32655092)
    • (2001) Annals of Oncology , vol.12 , Issue.6 , pp. 819-824
    • Berclaz, G.1    Altermatt, H.J.2    Rohrbach, V.3    Kieffer, I.4    Dreher, E.5    Andres, A.-C.6
  • 21
    • 0028900612 scopus 로고
    • Receptor tyrosine kinases expressed in metastatic colon cancer
    • Craven RJ, Xu LH, Weiner TM, et al: Receptor tyrosine kinases expressed in metastatic colon cancer. Int J Cancer 60: 791-797, 1995.
    • (1995) Int J Cancer , vol.60 , pp. 791-797
    • Craven, R.J.1    Xu, L.H.2    Weiner, T.M.3
  • 23
    • 0030787169 scopus 로고    scopus 로고
    • Overexpression of protein tyrosine kinases in human esophageal cancer
    • Nemoto T, Ohashi K, Akashi T, Johnson JD and Hirokawa K: Overexpression of protein tyrosine kinases in human esophageal cancer. Pathobiology 65: 195-203, 1997. (Pubitemid 27472525)
    • (1997) Pathobiology , vol.65 , Issue.4 , pp. 195-203
    • Nemoto, T.1    Ohashi, K.2    Akashi, T.3    Johnson, J.D.4    Hirokawa, K.5
  • 24
    • 33644876133 scopus 로고    scopus 로고
    • Expression of axl in lung adenocarcinoma and correlation with tumor progression
    • Shieh YS, Lai CY, Kao YR, et al: Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia 7: 1058-1064, 2005.
    • (2005) Neoplasia , vol.7 , pp. 1058-1064
    • Shieh, Y.S.1    Lai, C.Y.2    Kao, Y.R.3
  • 26
    • 0038688693 scopus 로고    scopus 로고
    • Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers
    • DOI 10.1093/annonc/mdg257
    • Sun WS, Fujimoto J and Tamaya T: Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers. Ann Oncol 14: 898-906, 2003. (Pubitemid 36827206)
    • (2003) Annals of Oncology , vol.14 , Issue.6 , pp. 898-906
    • Sun, W.S.1    Fujimoto, J.2    Tamaya, T.3
  • 27
    • 68049096311 scopus 로고    scopus 로고
    • Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival
    • Gustafsson A, Martuszewska D, Johansson M, et al: Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival. Clin Cancer Res 15: 4742-4749, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 4742-4749
    • Gustafsson, A.1    Martuszewska, D.2    Johansson, M.3
  • 28
    • 84871998076 scopus 로고    scopus 로고
    • An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
    • Byers LA, Diao L, Wang J, et al: An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res 19: 279-290, 2013.
    • (2013) Clin Cancer Res , vol.19 , pp. 279-290
    • Byers, L.A.1    Diao, L.2    Wang, J.3
  • 29
    • 70149109569 scopus 로고    scopus 로고
    • Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: Activation of AXL
    • Liu L, Greger J, Shi H, et al: Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res 69: 6871-6878, 2009.
    • (2009) Cancer Res , vol.69 , pp. 6871-6878
    • Liu, L.1    Greger, J.2    Shi, H.3
  • 31
    • 84887438346 scopus 로고    scopus 로고
    • Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib
    • Giles KM, Kalinowski FC, Candy PA, et al: Axl mediates acquired resistance of head and neck cancer cells to the epidermal growth factor receptor inhibitor erlotinib. Mol Cancer Ther 12: 2541-2558, 2013.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2541-2558
    • Giles, K.M.1    Kalinowski, F.C.2    Candy, P.A.3
  • 32
    • 0022739616 scopus 로고
    • Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol
    • Birt DF, Walker B, Tibbels MG and Bresnick E: Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis 7: 959-963, 1986.
    • (1986) Carcinogenesis , vol.7 , pp. 959-963
    • Birt, D.F.1    Walker, B.2    Tibbels, M.G.3    Bresnick, E.4
  • 33
    • 0032831286 scopus 로고    scopus 로고
    • Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
    • Liang YC, Huang YT, Tsai SH, Lin-Shiau SY, Chen CF and Lin JK: Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20: 1945-1952, 1999.
    • (1999) Carcinogenesis , vol.20 , pp. 1945-1952
    • Liang, Y.C.1    Huang, Y.T.2    Tsai, S.H.3    Lin-Shiau, S.Y.4    Chen, C.F.5    Lin, J.K.6
  • 34
    • 2442530445 scopus 로고    scopus 로고
    • Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-kappa B
    • Choi JS, Choi YJ, Park SH, Kang JS and Kang YH: Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B. J Nutr 134: 1013-1019, 2004.
    • (2004) J Nutr , vol.134 , pp. 1013-1019
    • Choi, J.S.1    Choi, Y.J.2    Park, S.H.3    Kang, J.S.4    Kang, Y.H.5
  • 36
    • 0030796989 scopus 로고    scopus 로고
    • 1 cell-cycle arrest by the chemopreventive agent apigenin
    • DOI 10.1002/(SICI)1098-2744(199707)19:2<74::AID-MC
    • Lepley DM and Pelling JC: Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin. Mol Carcinog 19: 74-82, 1997. (Pubitemid 27296738)
    • (1997) Molecular Carcinogenesis , vol.19 , Issue.2 , pp. 74-82
    • Lepley, D.M.1    Pelling, J.C.2
  • 37
    • 0842325655 scopus 로고    scopus 로고
    • Molecular Mechanisms for Apigenin-Induced Cell-Cycle Arrest and Apoptosis of Hormone Refractory Human Prostate Carcinoma DU145 Cells
    • DOI 10.1002/mc.10168
    • Shukla S and Gupta S: Molecular mechanisms for apigenin-induced cell-cycle arrest and apoptosis of hormone refractory human prostate carcinoma DU145 cells. Mol Carcinog 39: 114-126, 2004. (Pubitemid 38167115)
    • (2004) Molecular Carcinogenesis , vol.39 , Issue.2 , pp. 114-126
    • Shukla, S.1    Gupta, S.2
  • 38
    • 70349705633 scopus 로고    scopus 로고
    • Axl as a potential therapeutic target in cancer: Role of Axl in tumor growth, metastasis and angiogenesis
    • Li Y, Ye X, Tan C, et al: Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis. Oncogene 28: 3442-3455, 2009.
    • (2009) Oncogene , vol.28 , pp. 3442-3455
    • Li, Y.1    Ye, X.2    Tan, C.3
  • 39
    • 77957109253 scopus 로고    scopus 로고
    • An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
    • Ye X, Li Y, Stawicki S, et al: An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies. Oncogene 29: 5254-5264, 2010.
    • (2010) Oncogene , vol.29 , pp. 5254-5264
    • Ye, X.1    Li, Y.2    Stawicki, S.3
  • 40
    • 84882455547 scopus 로고    scopus 로고
    • HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors
    • Gusenbauer S, Vlaicu P and Ullrich A: HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors. Oncogene 32: 3846-3856, 2013.
    • (2013) Oncogene , vol.32 , pp. 3846-3856
    • Gusenbauer, S.1    Vlaicu, P.2    Ullrich, A.3
  • 41
    • 84864402225 scopus 로고    scopus 로고
    • Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
    • Zhang Z, Lee JC, Lin L, et al: Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer. Nat Genet 44: 852-860, 2012.
    • (2012) Nat Genet , vol.44 , pp. 852-860
    • Zhang, Z.1    Lee, J.C.2    Lin, L.3
  • 42
    • 84864416535 scopus 로고    scopus 로고
    • AXL and acquired resistance to EGFR inhibitors
    • Postel-Vinay S and Ashworth A: AXL and acquired resistance to EGFR inhibitors. Nat Genet 44: 835-836, 2012.
    • (2012) Nat Genet , vol.44 , pp. 835-836
    • Postel-Vinay, S.1    Ashworth, A.2
  • 43
    • 84858602428 scopus 로고    scopus 로고
    • Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells
    • Dufies M, Jacquel A, Belhacene N, et al: Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells. Oncotarget 2: 874-885, 2011.
    • (2011) Oncotarget , vol.2 , pp. 874-885
    • Dufies, M.1    Jacquel, A.2    Belhacene, N.3
  • 45
    • 84874643529 scopus 로고    scopus 로고
    • AXL mediates TRAIL resistance in esophageal adenocarcinoma
    • Hong J and Belkhiri A: AXL mediates TRAIL resistance in esophageal adenocarcinoma. Neoplasia 15: 296-304, 2013.
    • (2013) Neoplasia , vol.15 , pp. 296-304
    • Hong, J.1    Belkhiri, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.