AXL and acquired resistance to EGFR inhibitors

Nature Genetics

Volumn 44, Issue 8, 2012, Pages 835-836

  Postel Vinay, Sophie ^a,b   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AXL PROTEIN; ERLOTINIB; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

ANGIOGENESIS; ARTICLE; CANCER CELL; CANCER INVASION; CANCER RESISTANCE; CELL PROLIFERATION; CELL SURVIVAL; DRUG TARGETING; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO CULTURE; LUNG NON SMALL CELL CANCER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84864416535     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2362     Document Type: Article

References (12)

1. Lynch, T.J. et al. N. Engl. J. Med. 350, 2129-2139 (2004).
2. Paez, J.G. et al. Science 304, 1497-1500 (2004).
3. Pao, W. et al. Proc. Natl. Acad. Sci. USA 101, 13306-13311 (2004).
4. Sequist, L.V. et al. Sci. Transl. Med. 3, 75ra26 (2011).
5. Oxnard, G.R. et al. Clin. Cancer Res. 17, 1616-1622 (2011).
6. Zhang, Z. et al. Nat. Genet. 44, 852-860 (2012).
7. Verma, A., Warner, S.L., Vankayalapati, H., Bearss, D.J. & Sharma, S. Mol. Cancer Ther. 10, 1763-1773 (2011).
8. Linger, R.M., Keating, A.K., Earp, H.S. & Graham, D.K. Expert Opin. Ther. Targets 14, 1073-1090 (2010).
9. Ye, X. et al. Oncogene 29, 5254-5264 (2010).
10. Imai, K. & Takaoka, A. Nat. Rev. Cancer 6, 714-727 (2006).
11. Jackman, D. et al. J. Clin. Oncol. 28, 357-360 (2010).
12. Chaft, J.E. et al. Clin. Cancer Res. 17, 6298-6303 (2011).