메뉴 건너뛰기




Volumn 466, Issue 8, 2014, Pages 1581-1589

Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules

Author keywords

Epithelial transport; Microdissection; Microfluorimetry; mOCT1 2 knockout; mOCT2 knockout; Protein kinase; Regulation; Substrate specificity

Indexed keywords

CALMODULIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PHOSPHATIDYLINOSITOL 3 KINASE; ORGANIC CATION TRANSPORTER; SLC22A2 PROTEIN, HUMAN; SLC22A2 PROTEIN, MOUSE;

EID: 84904252639     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1395-9     Document Type: Article
Times cited : (19)

References (45)
  • 1
    • 33344454764 scopus 로고    scopus 로고
    • Tissue distribution and ontogeny of organic cation transporters in mice
    • DOI 10.1124/dmd.105.006932
    • Alnouti Y, Petrick JS, Klaassen CD (2006) Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos 34:477-482 (Pubitemid 43290907)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.3 , pp. 477-482
    • Alnouti, Y.1    Petrick, J.S.2    Klaassen, C.D.3
  • 5
    • 0037099380 scopus 로고    scopus 로고
    • Renal organic cation and nucleoside transport
    • DOI 10.1016/S0006-2952(02)01062-6, PII S0006295202010626
    • Chen R, Jonker JW, Nelson JA (2002) Renal organic cation and nucleoside transport. Biochem Pharmacol 64:185-190 (Pubitemid 34775297)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.2 , pp. 185-190
    • Chen, R.1    Jonker, J.W.2    Nelson J.Arly3
  • 6
    • 48749099279 scopus 로고    scopus 로고
    • Organic cation transporters
    • Ciarimboli G (2008) Organic cation transporters. Xenobiotica 38:936-971
    • (2008) Xenobiotica , vol.38 , pp. 936-971
    • Ciarimboli, G.1
  • 7
    • 79952132912 scopus 로고    scopus 로고
    • Role of organic cation transporters in drug-induced toxicity
    • Ciarimboli G (2011) Role of organic cation transporters in drug-induced toxicity. Expert Opin Drug Metab Toxicol 7:159-174
    • (2011) Expert Opin Drug Metab Toxicol , vol.7 , pp. 159-174
    • Ciarimboli, G.1
  • 16
    • 0034010850 scopus 로고    scopus 로고
    • Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)
    • Dresser MJ, Gray AT, Giacomini KM (2000) Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). J Pharmacol Exp Ther 292(3):1146-1152 (Pubitemid 30136612)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.292 , Issue.3 , pp. 1146-1152
    • Dresser, M.J.1    Gray, A.T.2    Giacomini, K.M.3
  • 18
    • 0032900120 scopus 로고    scopus 로고
    • Cloning and functional expression of a mouse liver organic cation transporter
    • DOI 10.1002/hep.510290530
    • Green RM, Lo K, Sterritt C, Beier DR (1999) Cloning and functional expression of a mouse liver organic cation transporter. Hepatology 29:1556-1562 (Pubitemid 29211060)
    • (1999) Hepatology , vol.29 , Issue.5 , pp. 1556-1562
    • Green, R.M.1
  • 19
    • 84863482551 scopus 로고    scopus 로고
    • Regulation of organic cation transport in isolated mouse proximal tubules involves complex changes in protein trafficking and substrate affinity
    • Guckel D, Ciarimboli G, Pavenstädt H, Schlatter E (2012) Regulation of organic cation transport in isolated mouse proximal tubules involves complex changes in protein trafficking and substrate affinity. Cell Physiol Biochem 30:269-281
    • (2012) Cell Physiol Biochem , vol.30 , pp. 269-281
    • Guckel, D.1    Ciarimboli, G.2    Pavenstädt, H.3    Schlatter, E.4
  • 20
    • 84862066298 scopus 로고    scopus 로고
    • Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics
    • Higgins JW, Bedwell DW, Zamek-Gliszczynski MJ (2012) Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics. Drug Metab Dispos 40:1170-1177
    • (2012) Drug Metab Dispos , vol.40 , pp. 1170-1177
    • Higgins, J.W.1    Bedwell, D.W.2    Zamek-Gliszczynski, M.J.3
  • 21
    • 0028213089 scopus 로고
    • Regulation by protein kinase C of the contraluminal transport system for organic cations in rabbit kidney S2 proximal tubules
    • Hohage H, Mörth DM, Querl IU, Greven J (1994) Regulation by protein kinase C of the contraluminal transport system for organic cations in rabbit kidney S2 proximal tubules. J Pharmacol Exp Ther 268:897-901 (Pubitemid 24085891)
    • (1994) Journal of Pharmacology and Experimental Therapeutics , vol.268 , Issue.2 , pp. 897-901
    • Hohage, H.1    Morth, D.M.2    Querl, I.U.3    Greven, J.4
  • 22
    • 80051549217 scopus 로고    scopus 로고
    • Properties and regulation of organic cation transport in freshly isolated mouse proximal tubules analyzed with a fluorescence reader-based method
    • Holle SK, Ciarimboli G, Edemir B, Neugebauer U, Pavenstädt H, Schlatter E (2011) Properties and regulation of organic cation transport in freshly isolated mouse proximal tubules analyzed with a fluorescence reader-based method. Pflugers Arch 462:359-369
    • (2011) Pflugers Arch , vol.462 , pp. 359-369
    • Holle, S.K.1    Ciarimboli, G.2    Edemir, B.3    Neugebauer, U.4    Pavenstädt, H.5    Schlatter, E.6
  • 23
    • 84855995429 scopus 로고    scopus 로고
    • Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney
    • Ito S, Kusuhara H, Yokochi M, Toyoshima J, Inoue K, Yuasa H, Sugiyama Y (2012) Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther 340:393-403
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 393-403
    • Ito, S.1    Kusuhara, H.2    Yokochi, M.3    Toyoshima, J.4    Inoue, K.5    Yuasa, H.6    Sugiyama, Y.7
  • 24
    • 0345866860 scopus 로고    scopus 로고
    • Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3)
    • DOI 10.1124/jpet.103.053298
    • Jonker JW, Schinkel AH (2004) Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3). J Pharmacol Exp Ther 308:2-9 (Pubitemid 38090693)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.308 , Issue.1 , pp. 2-9
    • Jonker, J.W.1    Schinkel, A.H.2
  • 25
    • 0142123151 scopus 로고    scopus 로고
    • Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations
    • DOI 10.1128/MCB.23.21.7902-7908.2003
    • Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH (2003) Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/ Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol 23:7902-7908 (Pubitemid 37271485)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.21 , pp. 7902-7908
    • Jonker, J.W.1    Wagenaar, E.2    Van Eijl, S.3    Schinkel, A.H.4
  • 27
    • 0031893146 scopus 로고    scopus 로고
    • Organic cation transporters in intestine, kidney, liver, and brain
    • Koepsell H (1998) Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 60:243-266
    • (1998) Annu Rev Physiol , vol.60 , pp. 243-266
    • Koepsell, H.1
  • 28
    • 3042569768 scopus 로고    scopus 로고
    • Polyspecific organic cation transporters: Their functions and interactions with drugs
    • Koepsell H (2004) Polyspecific organic cation transporters: their functions and interactions with drugs. Trends Pharmacol Sci 25:375-381
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 375-381
    • Koepsell, H.1
  • 29
    • 84875181483 scopus 로고    scopus 로고
    • The SLC22 family with transporters of organic cations, anions and zwitterions
    • Koepsell H (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. Mol Aspects Med 34:413-435
    • (2013) Mol Aspects Med , vol.34 , pp. 413-435
    • Koepsell, H.1
  • 31
    • 1242295185 scopus 로고    scopus 로고
    • The SLC22 drug transporter family
    • DOI 10.1007/s00424-003-1089-9, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Koepsell H, Endou H (2004) The SLC22 drug transporter family. Pflugers Arch 447:666-676 (Pubitemid 38241452)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 666-676
    • Koepsell, H.1    Endou, H.2
  • 32
    • 0032942525 scopus 로고    scopus 로고
    • Molecular pharmacology of organic cation transporters in kidney
    • DOI 10.1007/s002329900475
    • Koepsell H, Gorboulev V, Arndt P (1999) Molecular pharmacology of organic cation transporters in kidney. J Membr Biol 167:103-117 (Pubitemid 29061900)
    • (1999) Journal of Membrane Biology , vol.167 , Issue.2 , pp. 103-117
    • Koepsell, H.1    Gorboulev, V.2    Arndt, P.3
  • 34
    • 66449087083 scopus 로고    scopus 로고
    • Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule
    • Lee WK, Reichold M, Edemir B, Ciarimboli G,Warth R, Koepsell H, Thevenod F (2009) Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol 296:F1504-F1513
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Lee, W.K.1    Reichold, M.2    Edemir, B.3    Ciarimboli, G.4    Warth, R.5    Koepsell, H.6    Thevenod, F.7
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • -deltadeltaCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408 (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 38
    • 0035823636 scopus 로고    scopus 로고
    • Properties and regulation of organic cation transport in freshly isolated human proximal tubules
    • Pietig G,Mehrens T, Hirsch JR, Cetinkaya I, Piechota H, Schlatter E (2001) Properties and regulation of organic cation transport in freshly isolated human proximal tubules. J Biol Chem 276:33741-33746
    • (2001) J Biol Chem , vol.276 , pp. 33741-33746
    • Pietig, G.1    Mehrens, T.2    Hirsch, J.R.3    Cetinkaya, I.4    Piechota, H.5    Schlatter, E.6
  • 43
    • 1642357402 scopus 로고    scopus 로고
    • Organic Cation Transporter 3 (Slc22a3) Is Implicated in Salt-Intake Regulation
    • DOI 10.1523/JNEUROSCI.5147-03.2004
    • Vialou V, Amphoux A, Zwart R, Giros B, Gautron S (2004) Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci 24:2846-2851 (Pubitemid 38380963)
    • (2004) Journal of Neuroscience , vol.24 , Issue.11 , pp. 2846-2851
    • Vialou, V.1    Amphoux, A.2    Zwart, R.3    Giros, B.4    Gautron, S.5
  • 45
    • 84867743281 scopus 로고    scopus 로고
    • Endocrine and metabolic regulation of renal drug transporters
    • Yacovino LL, Aleksunes LM (2012) Endocrine and metabolic regulation of renal drug transporters. J Biochem Mol Toxicol 26(10):407-421
    • (2012) J Biochem Mol Toxicol , vol.26 , Issue.10 , pp. 407-421
    • Yacovino, L.L.1    Aleksunes, L.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.