Genetically modified mouse models for oral drug absorption and disposition

Current Opinion in Pharmacology

Volumn 13, Issue 6, 2013, Pages 853-858

  Tang, Seng Chuan ^a   Hendrikx, Jeroen J M A ^a,b   Beijnen, Jos H ^b,c   Schinkel, Alfred H ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CARNITINE; CEFADROXIL; DOCETAXEL; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; ETOPOSIDE; METFORMIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER 1; ORGANIC CATION TRANSPORTER 2; PACLITAXEL; PROTEIN ABCB1A; PROTEIN ABCB1B; PROTEIN OATP1A; PROTEIN OATP1B; RIBAVIRIN; THIONEINE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG EXCRETION; GENE EXPRESSION REGULATION; HUMAN; INTESTINE ABSORPTION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL TRANSPORT; INTESTINAL ABSORPTION; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MODELS, ANIMAL;

EID: 84888197104     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.08.011     Document Type: Review

References (38)

1. H. Lu, C. Chen, and C. Klaassen Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice Drug Metab Dispos 32 2004 1455 1461 (Pubitemid 39564566)
2. R. Govindarajan, A.H. Bakken, K.L. Hudkins, Y. Lai, F.J. Casado, M. Pastor-Anglada, C.M. Tse, J. Hayashi, and J.D. Unadkat In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta Am J Physiol Regul Integr Comp Physiol 293 2007 R1809 R1822
3. -/- mice J Pharmacol Exp Ther 331 2009 287 296
4. A.M. Moss, C.J. Endres, A. Ruiz-Garcia, D.S. Choi, and J.D. Unadkat Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice Mol Pharm 9 2012 2442 2449
5. T.K. Han, R.S. Everett, W.R. Proctor, C.M. Ng, C.L. Costales, K.L. Brouwer, and D.R. Thakker Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes Mol Pharmacol 84 2013 182 189
6. H. Koepsell, K. Lips, and C. Volk Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications Pharm Res 24 2007 1227 1251 (Pubitemid 46876495)
7. J.W. Jonker, E. Wagenaar, C.A. Mol, M. Buitelaar, H. Koepsell, J.W. Smit, and A.H. Schinkel Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene Mol Cell Biol 21 2001 5471 5477 (Pubitemid 32702451)
8. J.W. Higgins, D.W. Bedwell, and M.J. Zamek-Gliszczynski Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics Drug Metab Dispos 40 2012 1170 1177
9. T. Sugiura, S. Kato, T. Shimizu, T. Wakayama, N. Nakamichi, Y. Kubo, D. Iwata, K. Suzuki, T. Soga, and M. Asano Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver Drug Metab Dispos 38 2010 1665 1672
10. Y. Kato, M. Sugiura, T. Sugiura, T. Wakayama, Y. Kubo, D. Kobayashi, Y. Sai, I. Tamai, S. Iseki, and A. Tsuji Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse Mol Pharmacol 70 2006 829 837 (Pubitemid 44268440)
11. C. Misaka, F. Müller, and M.F. Fromm Clinical relevance of drug efflux pumps in the gut Curr Opin Pharmacol 2013 13
12. R.A. van Waterschoot, and A.H. Schinkel A critical analysis of the interplay between cytochrome P450 3A and P-glycoprotein: recent insights from knockout and transgenic mice Pharmacol Rev 63 2011 390 410
13. G. Jedlitschky, U. Hoffmann, and H.K. Kroemer Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition Expert Opin Drug Metab Toxicol 2 2006 351 366 (Pubitemid 46141403)
14. J.S. Lagas, M.L. Vlaming, O. van Tellingen, E. Wagenaar, R.S. Jansen, H. Rosing, J.H. Beijnen, and A.H. Schinkel Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics Clin Cancer Res 12 2006 6125 6132 (Pubitemid 44703778)
15. J.S. Lagas, L. Fan, E. Wagenaar, M.L. Vlaming, O. van Tellingen, J.H. Beijnen, and A.H. Schinkel P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 determine the pharmacokinetics of etoposide Clin Cancer Res 16 2010 130 140
16. R.A. van Waterschoot, J.S. Lagas, E. Wagenaar, H. Rosing, J.H. Beijnen, and A.H. Schinkel Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel Int J Cancer 127 2010 2959 2964
17. M.L. Vlaming, A. van Esch, E. van de Steeg, Z. Pala, E. Wagenaar, O. van Tellingen, and A.H. Schinkel Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate Drug Metab Dispos 39 2011 1338 1344
18. M.G. Belinsky, P.A. Dawson, I. Shchaveleva, L.J. Bain, R. Wang, V. Ling, Z.S. Chen, A. Grinberg, H. Westphal, and A. Klein-Szanto Analysis of the in vivo functions of Mrp3 Mol Pharmacol 68 2005 160 168 (Pubitemid 41002955)
19. N. Zelcer, K. van de Wetering, R. de Waart, G.L. Scheffer, H.U. Marschall, P.R. Wielinga, A. Kuil, C. Kunne, A. Smith, and M. van der Valk Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides J Hepatol 44 2006 768 775
20. D. Rost, S. Mahner, Y. Sugiyama, and W. Stremmel Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine Am J Physiol Gastrointest Liver Physiol 282 2002 G720 G726
21. T. Shoji, H. Suzuki, H. Kusuhara, Y. Watanabe, S. Sakamoto, and Y. Sugiyama ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine Am J Physiol Gastrointest Liver Physiol 287 2004 G749 G756
22. M. Hirouchi, H. Kusuhara, R. Onuki, B.W. Ogilvie, A. Parkinson, and Y. Sugiyama Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4 Drug Metab Dispos 37 2009 2103 2111
23. M.J. Zamek-Gliszczynski, K. Nezasa, X. Tian, A.S. Bridges, K. Lee, M.G. Belinsky, G.D. Kruh, and K.L. Brouwer Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice J Pharmacol Exp Ther 319 2006 1485 1491
24. Y. Kitamura, H. Kusuhara, and Y. Sugiyama Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse Pharm Res 27 2010 665 672
25. Y. Kitamura, M. Hirouchi, H. Kusuhara, J.D. Schuetz, and Y. Sugiyama Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3) J Pharmacol Exp Ther 327 2008 465 473
26. N. Zelcer, G. Reid, P. Wielinga, A. Kuil, I. van der Heijden, J.D. Schuetz, and P. Borst Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4) Biochem J 371 2003 361 367 (Pubitemid 36547618)
27. M. Hasegawa, H. Kusuhara, M. Adachi, J.D. Schuetz, K. Takeuchi, and Y. Sugiyama Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide J Am Soc Nephrol 18 2007 37 45 (Pubitemid 46053420)
28. L. Ci, H. Kusuhara, M. Adachi, J.D. Schuetz, K. Takeuchi, and Y. Sugiyama Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney Mol Pharmacol 71 2007 1591 1597 (Pubitemid 47010912)
29. T. Imaoka, H. Kusuhara, M. Adachi, J.D. Schuetz, K. Takeuchi, and Y. Sugiyama Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir Mol Pharmacol 71 2007 619 627 (Pubitemid 46147926)
30. F.G. Russel, J.B. Koenderink, and R. Masereeuw Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules Trends Pharmacol Sci 29 2008 200 207
31. C. Li, P.C. Krishnamurthy, H. Penmatsa, K.L. Marrs, X.Q. Wang, M. Zaccolo, K. Jalink, M. Li, D.J. Nelson, and J.D. Schuetz Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia Cell 131 2007 940 951 (Pubitemid 350138082)
32. X. Ming, and D.R. Thakker Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil Biochem Pharmacol 79 2010 455 462
33. D.R. de Waart, K. van de Wetering, C. Kunne, S. Duijst, C.C. Paulusma, and R.P. Oude Elferink Oral availability of cefadroxil depends on ABCC3 and ABCC4 Drug Metab Dispos 40 2012 515 521
34. A. Kalliokoski, and M. Niemi Impact of OATP transporters on pharmacokinetics Br J Pharmacol 158 2009 693 705
35. D. Iusuf, E. van de Steeg, and A.H. Schinkel Functions of OATP1A and 1B transporters in vivo: insights from mouse models Trends Pharmacol Sci 33 2012 100 108
36. E. van de Steeg, E. Wagenaar, C.M. van der Kruijssen, J.E. Burggraaff, D.R. de Waart, R.P. Elferink, K.E. Kenworthy, and A.H. Schinkel Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs J Clin Invest 120 2010 2942 2952
37. D. Iusuf, R.W. Sparidans, A. van Esch, M. Hobbs, K.E. Kenworthy, E. van de Steeg, E. Wagenaar, J.H. Beijnen, and A.H. Schinkel Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice Mol Pharm 9 2012 2497 2504
38. D. Iusuf, A. van Esch, M.J. Hobbs, M.A. Taylor, K.E. Kenworthy, E. van de Steeg, E. Wagenaar, and A.H. Schinkel Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure Mol Pharmacol 83 2013 919 929