Structure and function of renal organic cation transporters

News in Physiological Sciences

Volumn 13, Issue 1, 1998, Pages 11-16

  Koepsell, Hermann ^a   Busch, Andreas ^b   Gorboulev, Valentin ^a   Arndt, Petra ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 21944434991     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiologyonline.1998.13.1.11     Document Type: Article

References (15)

1. Busch, A. E., S. Quester, J. C. Ulzheimer, V. Gorboulev, A. Akhoundova, S. Waldegger, F. Lang, and H. Koepsell. Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 395: 153-156, 1996.
2. Busch, A. E., S. Quester, J. C. Ulzheimer, S. Waldegger, V. Gorboulev, P. Arndt, F. Lang, and H. Koepsell. Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J. Biol. Chem. 271: 32599-32604, 1996.
3. Gorboulev, V., J. C. Ulzheimer, A. Akhoundova, I. Ulzheimer-Teuber, U. Karbach, S. Quester, C. Baumann, F. Lang, A. E. Busch, and H. Koepsell. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 16: 871-881, 1997.
4. Groothuis, G. M. M., and D. K. F. Meijer. Drug traffic in the hepatobiliary system. J. Hepatol. 24: 3-28, 1996.
5. Gründemann, D., V. Gorboulev, S. Gambaryan, M. Veyhl, and H. Koepsell. Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372: 549-552, 1994.
6. Koehler, M. R., V. Gorboulev, H. Koepsell, C. Steinlein, and M. Schmid. Roct1, a rat polyspecific transporter gene for the excretion of cationic drugs, maps to chromosome 1q11-12. Mamm. Genome 7: 247-248, 1996.
7. Martel, F., T. Vetter, H. Russ, D. Gründemann, I. Azevedo, H. Koepsell, and E. Schömig. Transport of small organic cations in the rat liver: the role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch. Pharmacol. 354: 320-326, 1996.
8. Miller, D. S. Daunomycin secretion by killifish renal proximal tubules. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R370-R379, 1995.
9. Okuda, M., H. Saito, Y. Urakami, M. Takano, and K.-I. Inui. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. Commun. 224: 500-507, 1996.
10. Pritchard, J. B., D. B. Sykes, R., Walden, and D. S. Miller. ATP-dependent transport of tetraethylammonium by endosomes isolated from rat renal cortex. Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35): F966-F976, 1994.
11. Roch-Ramel F., K. Besseghir, and H. Murer. Renal excretion and tubular transport of organic anions and cations. In: Handbook of Physiology. Renal Physiology. Bethesda, MD: Am. Physiol. Soc., 1992, sect. 8, vol. II, chapt. 48, p. 2189-2262.
12. Ullrich, K. J. Specificity of transporters for "organic anions" and "organic cations" in the kidney. Biochim. Biophys. Acta 1197: 45-62, 1994.
13. -, pH; inhibition by aliphatic primary, secondary and tertiary amines, and mono- and bisquarternary compounds. Pflügers Arch. 419: 84-92, 1991.
14. + in relation to the other organic cation transport systems in the rat proximal tubule. Pflügers Arch. 432: 471-485, 1996.
15. Wright, S. H., T. M. Wunz, and T. P. Wunz. A choline transporter in renal brush-border membrane vesicles: energetics and structural specificity. J. Membr. Biol. 126: 51-65, 1992.