메뉴 건너뛰기




Volumn 8, Issue 1, 2011, Pages 270-279

New clues for nephrotoxicity induced by ifosfamide: Preferential renal uptake via the human organic cation transporter 2

Author keywords

Fanconi syndrome; Human kidney; Isolated proximal tubule; Nephrotoxicity; Oxazaphosphorine

Indexed keywords

CIMETIDINE; CYCLOPHOSPHAMIDE; IFOSFAMIDE; ORGANIC CATION TRANSPORTER 2;

EID: 79952124892     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100329u     Document Type: Article
Times cited : (88)

References (41)
  • 1
    • 0026014796 scopus 로고
    • Ifosfamide/mesna: A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer
    • Dechant, K. L.; Brogden, R. N.; Pilkington, T.; Faulds, D. Ifosfamide/Mesna. A Review of Its Antineoplastic Activity, Pharmacokinetic Properties and Therapeutic Efficacy in Cancer. Drugs 1991, 42, 428-467. (Pubitemid 21920771)
    • (1991) Drugs , vol.42 , Issue.3 , pp. 428-467
    • Dechant, K.L.1    Brogden, R.N.2    Pilkington, T.3    Faulds, D.4
  • 2
    • 0033951849 scopus 로고    scopus 로고
    • Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N- dechloroethylation of cyclophosphamide and ifosfamide
    • DOI 10.1016/S0006-2952(99)00410-4, PII S0006295299004104
    • Huang, Z.; Roy, P.; Waxman, D. J. Role of Human Liver Microsomal CYP3A4 and CYP2B6 in Catalyzing N-Dechloroethylation of Cyclophosphamide and Ifosfamide. Biochem. Pharmacol. 2000, 59, 961-972. (Pubitemid 30110812)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.8 , pp. 961-972
    • Huang, Z.1    Roy, P.2    Waxman, D.J.3
  • 3
    • 0033435199 scopus 로고    scopus 로고
    • Cyclophosphamide and mercaptoethane sulfonate therapy for minimal lesion glomerulonephritis [5]
    • DOI 10.1046/j.1523-1755.1999.00846.x
    • Kleta, R. Cyclophosphamide and Mercaptoethane Sulfonate Therapy for Minimal Lesion Glomerulonephritis. Kidney Int. 1999,56, 2312-2313. (Pubitemid 30004768)
    • (1999) Kidney International , vol.56 , Issue.6 , pp. 2312-2313
    • Kleta, R.1
  • 4
    • 0033049763 scopus 로고    scopus 로고
    • Development of ifosfamide-induced nephrotoxicity: Prospective follow-up in 75 patients
    • DOI 10.1002/(SICI)1096-911X(199903)32:3<177::AID-MPO3>3.0.CO;2-H
    • Rossi, R.; Pleyer, J.; Schafers, P.; Kuhn, N.; Kleta, R.; Deufel,T.; Jurgens, H. Development of Ifosfamide-Induced Nephrotoxicity: Prospective Follow-Up in 75 Patients. Med. Pediatr. Oncol.1999, 32, 177-182. (Pubitemid 29095976)
    • (1999) Medical and Pediatric Oncology , vol.32 , Issue.3 , pp. 177-182
    • Rossi, R.1    Pleyer, J.2    Schafers, P.3    Kuhn, N.4    Kleta, R.5    Deufel, T.6    Jurgens, H.7
  • 6
    • 0034911794 scopus 로고    scopus 로고
    • Human kidney tubules detoxify chloroacetaldehyde, a presumed nephrotoxic metabolite of ifosfamide
    • Dubourg, L.; Michoudet, C.; Cochat, P.; Baverel, G. Human Kidney Tubules Detoxify Chloroacetaldehyde, a Presumed Nephrotoxic Metabolite of Ifosfamide. J. Am. Soc. Nephrol. 2001, 12,1615-1623. (Pubitemid 32674423)
    • (2001) Journal of the American Society of Nephrology , vol.12 , Issue.8 , pp. 1615-1623
    • Dubourg, L.1    Michoudet, C.2    Cochat, P.3    Baverel, G.4
  • 7
    • 0028324490 scopus 로고
    • Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture
    • Mohrmann, M.; Ansorge, S.; Schmich, U.; Schonfeld, B.; Brandis,M. Toxicity of Ifosfamide, Cyclophosphamide and Their Metabolitesin Renal Tubular Cells in Culture. Pediatr. Nephrol. 1994,8, 157-163. (Pubitemid 24092249)
    • (1994) Pediatric Nephrology , vol.8 , Issue.2 , pp. 157-163
    • Mohrmann, M.1    Ansorge, S.2    Schmich, U.3    Schonfeld, B.4    Brandis, M.5
  • 8
    • 0027971523 scopus 로고
    • Ifosfamide metabolite chloroacetaldehyde causes fanconi syndrome in the perfused rat kidney
    • DOI 10.1006/taap.1994.1241
    • Zamlauski-Tucker, M. J.; Morris, M. E.; Springate, J. E. Ifosfamide Metabolite Chloroacetaldehyde Causes Fanconi Syndrome in the Perfused Rat Kidney. Toxicol. Appl. Pharmacol. 1994, 129, 170-175. (Pubitemid 24352635)
    • (1994) Toxicology and Applied Pharmacology , vol.129 , Issue.1 , pp. 170-175
    • Zamlauski-Tucker, M.J.1    Morris, M.E.2    Springate, J.E.3
  • 9
    • 0030971349 scopus 로고    scopus 로고
    • Nephrotoxicity of ifosfamide - Moving towards understanding the molecular mechanisms
    • DOI 10.1093/ndt/12.6.1091
    • Rossi, R. Nephrotoxicity of Ifosfamide-Moving Towards Understanding the Molecular Mechanisms. Nephrol., Dial., Transplant.1997, 12, 1091-1092. (Pubitemid 27230536)
    • (1997) Nephrology Dialysis Transplantation , vol.12 , Issue.6 , pp. 1091-1092
    • Rossi, R.1
  • 10
    • 0033006215 scopus 로고    scopus 로고
    • Renal involvement in children with malignancies
    • DOI 10.1007/s004670050585
    • Rossi, R.; Kleta, R.; Ehrich, J. H. Renal Involvement in Children With Malignancies. Pediatr. Nephrol. 1999, 13, 153-162. (Pubitemid 29206244)
    • (1999) Pediatric Nephrology , vol.13 , Issue.2 , pp. 153-162
    • Rossi, R.1    Kleta, R.2    Ehrich, J.H.H.3
  • 11
    • 30444441659 scopus 로고    scopus 로고
    • Metabolism and transport of oxazaphosphorines and the clinical implications
    • DOI 10.1080/03602530500364023, PII K78758H141354477
    • Zhang, J.; Tian, Q.; Yung, C. S.; Chuen, L. S.; Zhou, S.; Duan,W.; Zhu, Y. Z. Metabolism and Transport of Oxazaphosphorines and the Clinical Implications. Drug Metab Rev. 2005, 37, 611-703. (Pubitemid 43071142)
    • (2005) Drug Metabolism Reviews , vol.37 , Issue.4 , pp. 611-703
    • Zhang, J.1    Tian, Q.2    Sui, Y.C.3    Shu, C.L.4    Zhou, S.5    Duan, W.6    Zhu, Y.-Z.7
  • 12
    • 79952963076 scopus 로고    scopus 로고
    • Cytostatics and neurotransmitters are transported by the organic cation transporter in proximal cells
    • Stachon, A.; Hohage, H.; Feidt, C.; Kleta, R.; Schlatter, E.Cytostatics and Neurotransmitters Are Transported by the Organic Cation Transporter in Proximal Cells. Nova Acta Leopold. 1998,78, 333-338.
    • (1998) Nova Acta Leopold. , vol.78 , pp. 333-338
    • Stachon, A.1    Hohage, H.2    Feidt, C.3    Kleta, R.4    Schlatter, E.5
  • 13
    • 0027373329 scopus 로고
    • Bisubstrates: Substances that interact with renal contraluminal organic anion and organic cation transport systems. II. Zwitterionic substrates: dipeptides, cephalosporins, quinolone-carboxylate gyrase inhibitors and phosphamide thiazine carboxylates; Nonionizable substrates: Steroid hormones and cyclophosphamides
    • DOI 10.1007/BF00374180
    • Ullrich, K. J.; Rumrich, G.; David, C.; Fritzsch, G. Bisubstrates: Substances That Interact With Both, Renal Contraluminal Organic Anion and Organic Cation Transport Systems. II. Zwitterionic Substrates: Dipeptides, Cephalosporins, Quinolone-Carboxylate Gyrase Inhibitors and Phosphamide Thiazine Carboxylates; Nonionizable Substrates: Steroid Hormones and Cyclophosphamides. Pfluegers Arch. 1993, 425, 300-312. (Pubitemid 23338848)
    • (1993) Pflugers Archiv European Journal of Physiology , vol.425 , Issue.3-4 , pp. 300-312
    • Ullrich, K.J.1    Rumrich, G.2    David, C.3    Fritzsch, G.4
  • 14
    • 33847139479 scopus 로고    scopus 로고
    • Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
    • DOI 10.1007/s11095-006-9181-4
    • Rizwan, A. N.; Burckhardt, G. Organic Anion Transporters ofthe SLC22 Family: Biopharmaceutical, Physiological, and PathologicalRoles. Pharm. Res. 2007, 24, 450-470. (Pubitemid 46295167)
    • (2007) Pharmaceutical Research , vol.24 , Issue.3 , pp. 450-470
    • Rizwan, A.N.1    Burckhardt, G.2
  • 15
    • 0030763035 scopus 로고    scopus 로고
    • Cloning and characterization of two human polyspecific organic cation transporters
    • Gorboulev, V.; Ulzheimer, J. C.; Akhoundova, A.; Ulzheimer-Teuber, I.; Karbach, U.; Quester, S.; Baumann, C.; Lang, F.;Busch, A. E.; Koepsell, H. Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters. DNA Cell Biol.1997, 16, 871-881. (Pubitemid 27332696)
    • (1997) DNA and Cell Biology , vol.16 , Issue.7 , pp. 871-881
    • Gorboulev, V.1
  • 16
    • 21344450763 scopus 로고    scopus 로고
    • Cytochrome P450 3A and 2B6 in the developing kidney: Implications for ifosfamide nephrotoxicity
    • DOI 10.1007/s00467-004-1807-3
    • Aleksa, K.; Matsell, D.; Krausz, K.; Gelboin, H.; Ito, S.; Koren,G. Cytochrome P450 3A and 2B6 in the Developing Kidney: Implications for Ifosfamide Nephrotoxicity. Pediatr. Nephrol. 2005, 20, 872-885. (Pubitemid 40909254)
    • (2005) Pediatric Nephrology , vol.20 , Issue.7 , pp. 872-885
    • Aleksa, K.1    Matsell, D.2    Krausz, K.3    Gelboin, H.4    Ito, S.5    Koren, G.6
  • 19
    • 0028893080 scopus 로고
    • Effects of cell differentiationon ion conductances and membrane voltage in LLC-PK1 cells
    • Kleta, R.; Mohrmann, M.; Schlatter, E. Effects of Cell Differentiationon Ion Conductances and Membrane Voltage in LLC-PK1 Cells. Pfluegers Arch. 1995, 429, 370-377.
    • (1995) Pfluegers Arch. , vol.429 , pp. 370-377
    • Kleta, R.1    Mohrmann, M.2    Schlatter, E.3
  • 20
    • 0035823636 scopus 로고    scopus 로고
    • Properties and regulation of organic cation transport in freshly isolated human proximal tubules
    • Pietig, G.; Mehrens, T.; Hirsch, J. R.; Cetinkaya, I.; Piechota, H.; Schlatter, E. Properties and Regulation of Organic Cation Transport in Freshly Isolated Human Proximal Tubules. J. Biol.Chem. 2001, 276, 33741-33746.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33741-33746
    • Pietig, G.1    Mehrens, T.2    Hirsch, J.R.3    Cetinkaya, I.4    Piechota, H.5    Schlatter, E.6
  • 22
    • 0029048471 scopus 로고
    • Transport interactions of different organic cations during their excretion by the intact rat kidney
    • Pietruck, F.; Ullrich, K. J. Transport Interactions of Different Organic Cations During Their Excretion by the Intact Rat Kidney. Kidney Int. 1995, 47, 1647-1657.
    • (1995) Kidney Int. , vol.47 , pp. 1647-1657
    • Pietruck, F.1    Ullrich, K.J.2
  • 23
    • 84940142851 scopus 로고
    • Simple device for continuous measurement of fluorescent anions and cations in the rat kidney in situ
    • Rohlicek, V.; Ullrich, K. J. Simple Device for Continuous Measurement of Fluorescent Anions and Cations in the Rat Kidney in Situ. Renal Physiol. Biochem. 1994, 17, 57-61. (Pubitemid 24042445)
    • (1994) Renal Physiology and Biochemistry , vol.17 , Issue.2 , pp. 57-61
    • Rohlicek, V.1    Ullrich, K.J.2
  • 25
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays. J. Immunol. Methods 1983, 65, 55-63. (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 27
    • 0030916085 scopus 로고    scopus 로고
    • Nonlinear pharmacokinetics of cyclophosphamide and 4- hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation
    • Chen, T. L.; Kennedy, M. J.; Anderson, L. W.; Kiraly, S. B.;Black, K. C.; Colvin, O. M.; Grochow, L. B. Nonlinear Pharmacokinetics of Cyclophosphamide and 4-Hydroxycyclophosphamide/Aldophosphamide in Patients With Metastatic Breast Cancer Receiving High-Dose Chemotherapy Followed by Autologous Bone Marrow Transplantation. Drug Metab. Dispos. 1997, 25,544-551. (Pubitemid 27213094)
    • (1997) Drug Metabolism and Disposition , vol.25 , Issue.5 , pp. 544-551
    • Chen, T.-L.1    Kennedy, M.J.2    Anderson, L.W.3    Kiraly, S.B.4    Black, K.C.5    Colvin, O.M.6    Grochow, L.B.7
  • 28
    • 0023638209 scopus 로고
    • Repeated high-dose cyclophosphamide administration in bone marrow transplantation: Exposure to activated metabolites
    • DOI 10.1007/BF00570495
    • Schuler, U.; Ehninger, G.; Wagner, T. Repeated High-Dose Cyclophosphamide Administration in Bone Marrow Transplantation: Exposure to Activated Metabolites. Cancer Chemother. Pharmacol. 1987, 20, 248-252. (Pubitemid 17163404)
    • (1987) Cancer Chemotherapy and Pharmacology , vol.20 , Issue.3 , pp. 248-252
    • Schuler, U.1    Ehninger, G.2    Wagner, T.3
  • 30
    • 0017069422 scopus 로고
    • Studies on the human pharmacokinetics of isophosphamide (NSC-109724)
    • Allen, L. M.; Creaven, P. J.; Nelson, R. L. Studies on the Human Pharmacokinetics of Isophosphamide (NSC-109724). Cancer Treat. Rep. 1976, 60, 451-458.
    • (1976) Cancer Treat. Rep. , vol.60 , pp. 451-458
    • Allen, L.M.1    Creaven, P.J.2    Nelson, R.L.3
  • 32
    • 34249844568 scopus 로고    scopus 로고
    • Clinical pharmacology of cyclophosphamide and ifosfamide
    • Zhang, J.; Tian, Q.; Zhou, S. Clinical Pharmacology of Cyclophosphamide and Ifosfamide. Curr. Drug Ther. 2006, 1, 55-84.
    • (2006) Curr. Drug Ther. , vol.1 , pp. 55-84
    • Zhang, J.1    Tian, Q.2    Zhou, S.3
  • 34
    • 0031041912 scopus 로고    scopus 로고
    • Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo
    • DOI 10.1002/(SICI)1099-1263(199701)17:1<75::AID-JAT397>3.0.CO;2-C
    • Springate, J. E. Ifosfamide Metabolite Chloroacetaldehyde Causes Renal Dysfunction in Vivo. J. Appl. Toxicol. 1997, 17, 75-79. (Pubitemid 27091401)
    • (1997) Journal of Applied Toxicology , vol.17 , Issue.1 , pp. 75-79
    • Springate, J.E.1
  • 35
    • 0034010850 scopus 로고    scopus 로고
    • Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1)
    • Dresser, M. J.; Gray, A. T.; Giacomini, K. M. Kinetic and Selectivity Differences Between Rodent, Rabbit, and Human Organic Cation Transporters (OCT1). J. Pharmacol. Exp. Ther.2000, 292, 1146-1152. (Pubitemid 30136612)
    • (2000) Journal of Pharmacology and Experimental Therapeutics , vol.292 , Issue.3 , pp. 1146-1152
    • Dresser, M.J.1    Gray, A.T.2    Giacomini, K.M.3
  • 36
    • 0035066252 scopus 로고    scopus 로고
    • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
    • DOI 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO;2-D
    • Dresser, M. J.; Leabman, M. K.; Giacomini, K. M. Transporters Involved in the Elimination of Drugs in the Kidney: Organic Anion Transporters and Organic Cation Transporters. J. Pharm. Sci. 2001, 90, 397-421. (Pubitemid 32298045)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.4 , pp. 397-421
    • Dresser, M.J.1    Leabman, M.K.2    Giacomini, K.M.3
  • 37
    • 33645220096 scopus 로고    scopus 로고
    • Transport of drugs in the kidney by the human organic cation transporter OCT2 and its genetic variants
    • Fujita, T.; Urban, T. J.; Leabman, M. K.; Fujita, K.; Giacomini, K. M. Transport of Drugs in the Kidney by the Human Organic Cation Transporter, OCT2 and Its Genetic Variants. J. Pharm. Sci. 2006, 95, 25-36.
    • (2006) J. Pharm. Sci. , vol.95 , pp. 25-36
    • Fujita, T.1    Urban, T.J.2    Leabman, M.K.3    Fujita, K.4    Giacomini, K.M.5
  • 39
    • 53749097351 scopus 로고    scopus 로고
    • Fanconi or not Fanconi? Lowe syndrome revisited
    • Kleta, R. Fanconi or Not Fanconi? Lowe Syndrome Revisited. Clin. J. Am. Soc. Nephrol. 2008, 3, 1244-1245.
    • (2008) Clin. J. Am. Soc. Nephrol. , vol.3 , pp. 1244-1245
    • Kleta, R.1
  • 41
    • 0024592313 scopus 로고
    • Human renal Fanconi syndrome - Then and now
    • Foreman, J. W.; Roth, K. S. Human Renal Fanconi Syndrome - Then and Now. Nephron 1989, 51, 301-306. (Pubitemid 19056718)
    • (1989) Nephron , vol.51 , Issue.3 , pp. 301-306
    • Foreman, J.W.1    Roth, K.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.