Properties and Regulation of Organic Cation Transport in Freshly Isolated Human Proximal Tubules

Journal of Biological Chemistry

Volumn 276, Issue 36, 2001, Pages 33741-33746

  Pietig, Gesine ^a   Mehrens, Thomas ^a   Hirsch, Jochen R ^a   Çetinkaya, Ibrahim ^a   Piechota, Hansjürgen ^a   Schlatter, Eberhard ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOLOGICAL ORGANS; CHEMICAL ACTIVATION; ENZYMES; POSITIVE IONS;

ORGANIC CATION TRANSPORT;

BIOCHEMISTRY;

ADENYLATE CYCLASE; CALPHOSTIN C; CIMETIDINE; CYCLIC GMP DEPENDENT PROTEIN KINASE; FLUORESCENT DYE; TETRYLAMMONIUM; 1,2-DIOCTANOYLGLYCEROL; 4 (4 DIMETHYLAMINOSTYRYL) 1 METHYLPYRIDINIUM; 4-(4-DIMETHYLAMINOSTYRYL)-1-METHYLPYRIDINIUM; 8 BROMO CYCLIC GMP; 8-BROMOCYCLIC GMP; CATION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; DIACYLGLYCEROL; DIOCTANOIN; DRUG DERIVATIVE; MESSENGER RNA; POTASSIUM; PROTEIN KINASE C; PYRIDINIUM DERIVATIVE;

ARTICLE; BASOLATERAL MEMBRANE; CATION TRANSPORT; CONCENTRATION RESPONSE; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ISOLATED KIDNEY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MEMBRANE VESICLE; MOLECULAR CLONING; PRIORITY JOURNAL; XENOBIOTIC METABOLISM; CELL MEMBRANE; DOSE RESPONSE; HELA CELL; KIDNEY TUBULE; KINETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROFLUOROMETRY; TRANSPORT AT THE CELLULAR LEVEL;

CANIS FAMILIARIS; CINCHONA PUBESCENS; ORYCTOLAGUS CUNICULUS;

BIOLOGICAL TRANSPORT; CATIONS; CELL MEMBRANE; CLONING, MOLECULAR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; HELA CELLS; HUMANS; KIDNEY TUBULES; KINETICS; POTASSIUM; PROTEIN KINASE C; PYRIDINIUM COMPOUNDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROMETRY, FLUORESCENCE;

EID: 0035823636     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104617200     Document Type: Article

References (38)

1. Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., and Koepsell, H. (1994) Nature 372, 549-552
2. Gorboulev, V., Ulzheimer, J. C., Akhoundova, A., Ulzheimer-Teuber, I., Karbach, U., Quester, S., Baumann, C., Busch, A. E., Lang, F., and Koepsell, H. (1997) DNA Cell Biol. 16, 871-881
3. Zhang, L., Dresser, M. J., Gray, A. T., Yost, S. C., Terashita, S., and Giacomini, K. M. (1997) Mol. Pharmacol. 51, 913-921
4. Tamai, I., Yabuuchi, H., Nezu, J., Sai, Y., Oku, A., Shimane, M., and Tsuji, A. (1997) FEBS Lett. 419, 107-111
5. Wu, X., Prasad, P. D., Leibach, F. H., and Ganapathy, V. (1998) Biochem. Biophys. Res. Commun. 246, 589-595
6. Gründemann, D., Schechinger, B., Rappold, G. A., and Schömig, E. (1998) Nat. Neurosci. 1, 349-351
7. Ullrich, K. J. (1999) in Membrane Transporters as Drug Targets, pp. 159-179, (Amidon, G. L., and Sadée, W., eds) Kluwer Academic/Plenum Publishers, New York
8. Ullrich, K. J., Papavassiliou, F., David, C., Rumrich, G., and Fritzsch, G. (1991) Pfluegers Arch. 419, 84-92
9. David, C., Rumrich, G., and Ullrich, K. J. (1995) Pfluegers Arch. 430, 477-492
10. Wright, S. H. (1985) Am. J. Physiol. 249, F903-F911
11. Wright, S. H., and Wunz, T. M. (1987) Am. J. Physiol. 253, F1040-F1050
12. Holohan, P. D., and Ross, C. R. (1981) J. Pharmacol. Exp. Ther. 216, 294-298
13. Yabuuchi, H., Tamai, I., Nezu, J., Sakamoto, K., Oku, A., Shimane, M., Sai, Y., and Tsuji, A. (1999) J. Pharmacol. Exp. Ther. 289, 768-773
14. Sweet, D. H., Miller, D. S., and Pritchard, J. B. (2000) Am. J. Physiol. 279, F826-F834
15. Sugawara-Yokoo, M., Urakami, Y., Koyama, H., Fujikura, K., Masuda, S., Saito, H., Naruse, T., Inui, K., and Takata, K. (2000) Histochem. Cell Biol. 114, 175-180
16. Karbach, U., Kricke, J., Meyer-Wentrup, F., Gorboulev, V., Volk, C., Loffing-Cueni, D., Kaissling, B., Bachmann, S., and Koepsell, H. (2000) Am. J. Physiol. 279, F679-F687
17. Koepsell, H., Gorboulev, V., and Arndt, P. (1999) J. Membr. Biol. 167, 103-117
18. Pritchard, J. B., and Miller, D. S. (1997) Adv. Drug Delivery Rev. 25, 231-242
19. Busch, A. E., Quester, S., Ulzheimer, J. C., Waldegger, S., Gorboulev, V., Arndt, P., Lang, F., and Koepsell, H. (1996) J. Biol. Chem. 271, 32599-32604
20. Zhang, L., Schaner, M. E., and Giacomini, K. M. (1998) J. Pharmacol. Exp. Ther. 286, 354-361
21. Zhang, L., Gorset, W., Dresser, M. J., and Giacomini, K. M. (1999) J. Pharmacol. Exp. Ther. 288, 1192-1198
22. Dresser, M. J., Gray, A. T., and Giacomini, K. M. (2000) J. Pharmacol. Exp. Ther. 292, 1146-1152
23. Breidert, T., Spitzenberger, F., Gründemann, D., and Schömig, E. (1998) Br. J. Pharmacol. 125, 218-224
24. Nagel, G., Volk, C., Friedrich, T., Ulzheimer, J. C., Bamberg, E., and Koepsell, H. (1997) J. Biol. Chem. 272, 31953-31956
25. Boom, S. P., Gribnau, F. W., and Russel, F. G. (1992) J. Pharmacol. Exp. Ther. 263, 445-450
26. Berkhin, E. B., and Humphreys, M. H. (2001) Kidney Int. 59, 17-30
27. Hohage, H., Mörth, D. M., Querl, I. U., and Greven, J. (1994) J. Pharmacol. Exp. Ther. 268, 897-901
28. Mehrens, T., Lelleck, S., Çetinkaya, I., Knollmann, M., Hohage, H., Gorboulev, V., Boknik, P., Koepsell, H., and Schlatter, E. (2000) J. Am. Soc. Nephrol. 11, 1216-1224
29. Hohage, H., Stachon, A., Feidt, C., Hirsch, J. R., and Schlatter, E. (1998) J. Pharmacol. Exp. Ther. 286, 305-310
30. Schafer, J. A., Watkins, M. L., Li, L., Herter, P., Haxelmans, S., and Schlatter, E. (1997) Am. J. Physiol. 273, F650-F657
31. Derst, C., Hirsch, J. R., Preisig-Müller, R., Wischmeyer, E., Karschin, A., Döring, F., Thomzig, A., Veh, R. W., Schlatter, E., Kummer, W., and Daut, J. (2001) Kidney Int. 59, 2197-2205
32. Derst, C., Karschin, C., Wischmeyer, E., Hirsch, J. R., Preisig-Müller, R., Rajan, S., Engel, H., Grzeschik, K., Daut, J., and Karschin, A. (2001) FEBS Lett. 491, 305-311
33. Schlatter, E., and Schafer, J. A. (1987) Pfluegers Arch. 409, 81-92
34. Stachon, A., Schlatter, E., and Hohage, H. (1996) Cell. Physiol. Biochem. 6, 72-81
35. Stachon, A., Hohage, H., Feidt, C., and Schlatter, E. (1997) Cell. Physiol. Biochem. 7, 264-274
36. Hirsch, J. R., Loo, D. D. F., and Wright, E. M. (1996) J. Biol. Chem. 271, 14740-14746
37. Pietruck, F., and Ullrich, K. J. (1995) Kidney Int. 47, 1647-1657
38. Burckhardt, G., and Wolff, N. A. (2000) Am. J. Physiol. 278, F853-F866