Regulation of organic cation transport in isolated mouse proximal tubules involves complex changes in protein trafficking and substrate affinity

Cellular Physiology and Biochemistry

Volumn 30, Issue 1, 2012, Pages 269-281

  Guckel, Denise ^a   Ciarimboli, Giuliano ^a   Pavenstdt, Hermann ^a   Schlatter, Eberhard ^a,b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Medizinische Klinik und Poliklinik D   (Germany)

Author keywords

Microfluorimetry; Organic cation transport; Protein kinases; Proximal tubule; Substrate affinities; Trafficking

Indexed keywords

ANGIOTENSIN II; BAFILOMYCIN; CALCIUM; CALMODULIN; COLCHICINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ORGANIC CATION TRANSPORTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN P56; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PYRIDINIUM DERIVATIVE;

ANALYTIC METHOD; ARTICLE; BASOLATERAL MEMBRANE; CELL FUNCTION; CONTROLLED STUDY; CYTOSKELETON; DIXON PLOT ANALYSIS; ENDOSOME; ENZYME INHIBITION; FLUORESCENCE; KIDNEY PROXIMAL TUBULE; LYSOSOME; MALE; MICROTITER PLATE ASSAY; MICROTUBULE; MOUSE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 84863482551     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000339063     Document Type: Article

References (36)

1. Ciarimboli G: Organic cation transporters. Xenobiotica 2008;38:936-971.
2. Ciarimboli G, Schlatter E: Regulation of organic cation transport. Pflugers Arch 2005;449:423-441. (Pubitemid 40238877)
3. Berkhin EB, Humphreys MH: Regulation of renal tubular secretion of organic compounds. Kidney Int 2001;59:17-30. (Pubitemid 32055210)
4. Koepsell H, Endou H: The SLC22 drug transporter family. Pflugers Arch 2004;447:666-676. (Pubitemid 38241452)
5. Bourdet DL, Pritchard JB, Thakker DR: Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCTl; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther 2005;315:1288-1297. (Pubitemid 41635417)
6. Ciarimboli G, Ludwig T, Lang D, Pavenstadt H, Koepsell H, Piechota H J, Haier J, Jaehde U, Zisowsky J, Schlatter E: Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol 2005;167:1477-1484. (Pubitemid 41713303)
7. Ciarimboli G, Holle SK, Vollenbroker B, Hagos Y, Reuter S, Burckhardt G, Bierer S, Herrmann E, Pavenstadt H, Rossi R, Kleta R, Schlatter E: New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2. Mol Pharm 2011;8:270-279.
8. Ciarimboli G, Deuster D, Knief A, Sperling M, Holtkamp M, Edemir B, Pavenstadt H, Lanvers-Kaminsky C, am Zehnhoff-Dinnesen A, Schinkel AH, Koepsell H, Jlirgens H, Schlatter E: Organic cation transporter 2 mediates cisplatin-induced oto-and nephrotoxicity and is a target for protective interventions. Am J Pathol 2010;176:1169-1180.
9. Ciarimboli G: Role of organic cation transporters in drug-induced toxicity. Expert Opin Drug Metab Toxicol 2011;7:159-174.
10. Hasannejad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, Jung SH, Onozato ML, Tojo A, Endou H: Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs. Eur J Pharmacol 2004;499:45-51. (Pubitemid 39201210)
11. Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM: Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharm Res 2011;28:610-625.
12. Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCTl. J Biol Chem 1996;271:32599-32604. (Pubitemid 27008679)
13. Kekuda R, Prasad PD, Wu X, Wang H, Fei Y J, Leibach FH, Ganapathy V: Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 1998;273:15971-15979. (Pubitemid 28311362)
14. Koepsell H, Schmitt BM, Gorboulev V: Organic cation transporters. Rev Physiol Biochem Pharmacol 2003;150:36-90.
15. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 1997;16:871-881. (Pubitemid 27332696)
16. Griindemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H: Drug excretion mediated by a new prototype of polyspecific transporter. Nature 1994;372:549-552. (Pubitemid 24368536)
17. Mehrens T, Lelleck S, Cetinkaya I, Knollmann M, Hohage H, Gorboulev V, Boknik P, Koepsell H, Schlatter E: The affinity of the organic cation transporter rOCTl is increased by protein kinase C-dependent phosphorylation. J Am Soc Nephrol 2000;11:1216-1224. (Pubitemid 30416217)
18. Koepsell H, Gorboulev V, Arndt P: Molecular pharmacology of organic cation transporters in kidney. J MembrBiol 1999;167:103-117. (Pubitemid 29061900)
19. Koepsell H, Busch A, Gorboulev V, Arndt P: Structure and Function of Renal Organic Cation Transporters. News Physiol Sci 1998;13:11-16.
20. Holle SK, Ciarimboli G, Edemir B, Neugebauer U, Pavenstadt H, Schlatter E: Properties and regulation of organic cation transport in freshly isolated mouse proximal tubules analyzed with a fluorescence reader-based method. Pflugers Arch 2011;462:359-369.
21. Cetinkaya I, Ciarimboli G, Yalcinkaya G, Mehrens T, Velic A, Hirsch JR, Gorboulev V, Koepsell H, Schlatter E: Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases. Am J Physiol Renal Physiol 2003;284:F293-F302. (Pubitemid 36114692)
22. Pietig G, Mehrens T, Hirsch JR, Cetinkaya I, Piechota H, Schlatter E: Properties and regulation of organic cation transport in freshly isolated human proximal tubules. J Biol Chem 2001;276:33741-33746.
23. Wilde S, Schlatter E, Koepsell H, Edemir B, Reuter S, Pavenstadt H, Neugebauer U, Schroter R, Brast S, Ciarimboli G: Calmodulin-associated post-translational regulation of rat organic cation transporter 2 in the kidney is gender dependent. Cell Mol Life Sci 2009;66:1729-1740.
24. Ciarimboli G, Koepsell H, Iordanova M, Gorboulev V, Durner B, Lang D, Edemir B, Schroter R, Van LT, Schlatter E: Individual PKC-phosphorylation sites in organic cation transporter 1 determine substrate selectivity and transport regulation. J Am Soc Nephrol 2005;16:1562-1570. (Pubitemid 41716463)
25. Hohage H, Morth DM, Querl HI, Greven J : Regulation by protein kinase C of the contraluminal transport system for organic cations in rabbit kidney S2 proximal tubules. J Pharmacol Exp Ther 1994;268:897-901. (Pubitemid 24085891)
26. Urakami Y, Okuda M, Saito H, Inui K: Hormonal regulation of organic cation transporter OCT2 expression in rat kidney. FEBS Lett 2000;473:173-176. (Pubitemid 30254285)
27. Volk C, Gorboulev V, Budiman T, Nagel G, Koepsell H: Different affinities of inhibitors to the outwardly and inwardly directed substrate binding site of organic cation transporter 2. Mol Pharmacol 2003;64:1037-1047. (Pubitemid 37310736)
28. Biermann J, Lang D, Gorboulev V, Koepsell H, Sindic A, Schroter R, Zvirbliene A, Pavenstadt H, Schlatter E, Ciarimboli G: Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am J Physiol Cell Physiol 2006;290:C1521-C1531. (Pubitemid 43830792)
29. Ciarimboli G, Struwe K, Arndt P, Gorboulev V, Koepsell H, Schlatter E, Hirsch JR: Regulation of the human organic cation transporter hOCTl. J Cell Physiol 2004;201:420-428. (Pubitemid 39456441)
30. Martel F, Keating E, Calhau C, Griindemann D, Schomig E, Azevedo I: Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems. Naunyn Schmiedebergs Arch Pharmacol 2001;364:487-495. (Pubitemid 33145087)
31. Brown D, Paunescu TG, Breton S, Marshansky V: Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol 2009;212:1762-1772.
32. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP: Renal vacuolar H*-ATPase. Physiol Rev 2004;84:1263-1314.
33. Cheung PY, Lai WP, Lau HY, Lo SC, Wong MS: Acute and chronic effect of dietary phosphorus restriction on protein expression in young rat renal proximal tubules. Proteomics 2002;2:1211-1219.
34. Murer H, Forster I, Hilfiker H, Pfister M, Kaissling B, Lotscher M, Biber J : Cellular/molecular control of renal Na/Pi-cotransport. Kidney Int Suppl 1998;65:S2-10.
35. Murer H, Lotscher M, Kaissling B, Biber J : Molecular mechanisms in the regulation of renal proximal tubular Na/phosphate cotransport. Kidney Blood Press Res 1996;19:151-154. (Pubitemid 26379980)
36. Ahmad A, Khundmiri S J, Pribble F, Merchant ML, Ameen M, Klein JB, Levi M, Lederer ED: Role of vacuolar ATPase in the trafficking of renal type Ha sodium-phosphate cotransporter. Cell Physiol Biochem 2011;27:703-714.