Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 334-341

  Liu, Yang ^a   Meng, Ge ^a   Zheng, Aqun ^a   Chen, Fener ^b   Chen, Wenxue ^b   Clercq, Erik De ^c   Pannecouque, Christophe ^c   Balzarini, Jan ^c  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti HIV activity; Cyclopropylamine; Diarylpyrimidine; Non nucleoside RT inhibitors; SAR

Indexed keywords

4 [[4 [(2 CHLOROPHENYL)(CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(3 BROMOPHENYL)(CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(3 CHLOROPHENYL)(CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 BROMOPHENYL)(CYCLOPROPYLAMINO)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 BROMOPHENYL)(CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 CHLOROPHENYL)(4 FLUOROPHENYL)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(4 CHLOROPHENYL)(CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(2,4 DICHLOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(2,5 DIFLUOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(3 FLUOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(4 FLUOROPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(4 METHOXYPHENYL)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(4 METHOXYPHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(4 TOLYLL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(NAPHTHALEN 1 YL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(NAPHTHALEN 2 YL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINO)(PHENYL)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [(CYCLOPROPYLAMINOL)(4 FLUOROPHENYL)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[ (TERT BUTYL) PHENYL](CYCLOPROPYLAMINO)METHYL] 6 METHYLPYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 (2 CYANOVINYL)PHENYL](CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; 4 [[4 [[4 (TERT BUTYL)PHENYL](CYCLOPROPYLAMINO)METHYL]PYRIMIDIN 2 YL]AMINO]BENZONITRILE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DELAVIRDINE; EFAVIRENZ; ETRAVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; SYNTHESIS; TUMOR CELL LINE;

ANTI-HIV AGENTS; CELL LINE, TUMOR; DRUG DESIGN; HIV-1; HIV-2; HUMANS; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904216103     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.06.003     Document Type: Article

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