Novel cyclopropyl-indole derivatives as HIV non-nucleoside reverse transcriptase inhibitors

ACS Medicinal Chemistry Letters

Volumn 3, Issue 6, 2012, Pages 470-475

  Hassam, Mohammad ^a   Basson, Adriaan E ^b   Liotta, Dennis C ^c   Morris, Lynn ^b   Van Otterlo, Willem A L ^a   Pelly, Stephen C ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^c EMORY UNIVERSITY   (United States)

Author keywords

cyclopropyl; HIV; indole; NNRTI; rational design

Indexed keywords

ALCOHOL; AMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOXYLIC ACID; INDOLE DERIVATIVE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; TYROSINE; VALINE;

ALLOSTERISM; AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG EFFICACY; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; REDUCTION; TOXICITY TESTING; VIRUS REPLICATION; WILD TYPE;

EID: 84862298277     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml3000462     Document Type: Article

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22. PDB ID: 2RF2.
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