Synthesis of 1-[(2-hydroxyethoxy)methyl] 6-(5,6,7,8- tetrahydronaphthylmethyl-1) thymine as novel inhibitor against drug-resistant HIV mutants

Synthetic Communications

Volumn 35, Issue 8, 2005, Pages 1095-1102

  Meng, Ge ^a   Kuang, Yun Yan ^a   Ji, Lei ^a   Chen, Fen Er ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

HEPT; HEPT analogues; HIV 1 RT inhibitors

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (2 METHOXY 5,6,7,8 TETRAHYDRONAPHTHYLMETHYL 1)THYMINE; 1 [(2 HYDROXYETHOXY)METHYL] 6 (5,6,7,8 TETRAHYDRONAPHTHYLMETHYL 1)THYMINE; 1 [[2 [(TERT BUTYLDIMETHYLSILYL)OXY]ETHOXY]METHYL] 6 (1 ACETOXY 1 NAPHTHYLMETHYL 1)THYMINE; 1 [[2 [(TERT BUTYLDIMETHYLSILYL)OXY]ETHOXY]METHYL] 6 [1 ACETOXY 1 (2 OXYNAPHTHYL)METHYL 1]THYMINE; EMIVIRINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THYMINE DERIVATIVE; TNK 6123; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEPROTECTION REACTION; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGENATION; HYDROGENOLYSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

EID: 17044411297     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-200054213     Document Type: Article

References (12)

1. (a) Balzarini, J.; Karlsson, A.; Clercq, E. D. Mol Pharmacol. 1993, 44, 694;
2. (b) Balzarini, J.; Baba, M.; Clercq, E. D. Antimicrob Agents Chemother. 1995, 39, 998;
3. (c) Robert, W.; Buckheit, J. R.; Valerie, F. B. Virology 1995, 210, 186.
4. Baba, M.; De Clercq, E.; Iida, S.; Tanaka, H.; Nitta, I.; UbaSawa, M.; Takashima, H.; Sekiya, K.; Umezu, K.; Nakashima, H.; Shigeta, S.; Richard, T.; Walker, R. T.; and Miyasaka, T. Antimicrob Agents Chemother. 1990, 34, 2358.
5. Hopkins, A. L.; Ren, J.; Tanaka, H.; Baba, M.; Okamato, M.; Stuart, D. I.; Stammers, D. K. J. Med. Chem. 1999, 42, 4500-4505.
6. Tantillo, C.; Ding, J.; Jacoba-Molina, A.; Nanni, R. G.; Boyer, P.L.; Hughes, S. H.; Pauwels, R.; Andries, K.; Janssen, P. A. J.; Arnold, E. J. Mol. Biol. 1994, 243, 369
7. (a) Hopkins, A. L.; Ren, J.; Esnouf, R. M.; Willcox, B. E.; Jones, E. Y.; Ross, C.; Miyasaka, T.; Walker, R. T.; Tanaka, H.; Stammers, D. K.; Stuart, D. I. J. Med. Chem. 1996, 39, 1589;
8. (b) Danel, K.; Larsen, E.; Pedersen, E. B.; Vestergaard, B. F.; Nielsen, C. J. Med. Chem. 1996, 339, 2427;
9. (c) Mai, A.; Artico, M.; Sbardella, G.; Massa, S.; Loi, A. G.; Tramontano, E.; Scano, P.; Colla, P. L. J. Med. Chem. 1995, 38, 3258.
10. Meng, G.; Chen, F. E.; Clercq, D.; Balzarini, J.; Pannecouque, C. Chem. Pharm. Bull. 2003, 51, 779.
11. Rosowsky, A.; Kim, S. H.; Wick, M. J. Med. Chem. 1981, 24, 1177.
12. Tanaka, H.; Takashima, H.; Ubasawa, M.; Sekiya, K.; Inouye, N.; Baba, M.; Shigeta, S.; Walker, R. T.; De Clercq, E.; Miyasaka, T. J. Med. Chem. 1995, 38, 2860.