Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 107-117

  Di Pietro, Ornella ^a   Pérez Areales, F Javier ^a   Juárez Jiménez, Jordi ^a   Espargaró, Alba ^a   Clos, M Victòria ^b   Pérez, Belén ^b   Lavilla, Rodolfo ^a   Sabaté, Raimon ^a   Luque, F Javier ^a   Muñoz Torrero, Diego ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT DE NEUROCIÈNCIES   (Spain)

Author keywords

A aggregation inhibitors; Dual binding site AChE inhibitors; Multitarget compounds; Tau aggregation inhibitors; Tetrahydrobenzo h 1,6 naphthyridines

Indexed keywords

ACETYLCHOLINESTERASE; AMIDE; AMYLOID BETA PROTEIN[1-42]; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINESTERASE; N [3 [(6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL] 5 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROBENZO[H][1,6]NAPHTHYRIDINE 9 CARBOXAMIDE; N [4 [(6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]BUTYL] 5 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROBENZO[H][1,6]NAPHTHYRIDINE 9 CARBOXAMIDE; N [5 [(6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PENTYL] 5 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROBENZO[H][1,6]NAPHTHYRIDINE 9 CARBOXAMIDE; N [8 [(6 CHLORO 1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]OCTYL] 5 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROBENZO[H][1,6]NAPHTHYRIDINE 9 CARBOXAMIDE; NAPHTHYRIDINE DERIVATIVE; TACRINE; TAU PROTEIN; TETRAHYDROBENZO[H][1,6]NAPHTHYRIDINE 6 CHLOROTACRINE; UNCLASSIFIED DRUG; 6 CHLOROTACRINE; CHOLINESTERASE INHIBITOR; AMYLOID BETA PROTEIN; N-(3-((6-CHLORO-1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO)PROPYL)-5-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROBENZO(H)(1,6)NAPHTHYRIDINE-9-CARBOXAMIDE;

ACUTE TOXICITY; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; BRAIN MEMBRANE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG SAFETY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IC 50; IN VITRO STUDY; INTESTINE ABSORPTION; LD 50; MEMBRANE MODEL; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR HYBRIDIZATION; MOLECULAR WEIGHT; NONHUMAN; PROTEIN AGGREGATION; RAT; DRUG ACTIVITY; DRUG STRUCTURE; IC50; MOLECULAR MODEL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TAUOPATHIES;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE; TAU PROTEINS; TAUOPATHIES;

EID: 84904170030     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.021     Document Type: Article

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