Intracellular Signaling and Regulation of Cardiac Ion Channels

Cardiac Electrophysiology: Fourth Edition

Volumn , Issue , 2004, Pages 33-41

  Khositseth, Anant ^a   Clapham, David E ^b,c,d   Ackerman, Michael J ^a,e  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84904138929     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B0-7216-0323-8/50007-5     Document Type: Chapter

References (65)

1. Ackerman MJ, Clapham DE Ion channels: Basic science and clinical disease. N Engl J Med 1997, 336:1575-1586.
2. Aiyar J, Withka JM, Rizzi JP, et al. Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins. Neuron 1995, 15:1169-1181.
3. Doyle DA, Morais Cabral J, Pfuetzner RA, et al. The structure of the potassium channel: Molecular basis of K+ conduction and selectivity. Science 1998, 280:69-77.
4. Yellen G The voltage-gated potassium channels and their relatives. Nature 2002, 419:35-42.
5. Wickman K, Nemec J, Gendler SJ, Clapham DE Abnormal heart rate regulation in GIRK4 knockout mice. Neuron 1998, 20:103-114.
6. Clapham DE, Neer EJ G protein beta gamma subunits. Annu Rev Pharmacol Toxicol 1997, 37:167-203.
7. Wickman KD, Iniguez-Lluhl JA, Davenport PA, et al. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature 1994, 368:255-257.
8. Huang CL, Jan YN, Jan LY Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. FEBS Lett 1997, 405:291-298.
9. He C, Zhang H, Mirshahi T, Logothetis DE Identification of a potassium channel site that interacts with G protein betagamma subunits to mediate agonist-induced signaling. J Biol Chem 1999, 274:12517-12524.
10. He C, Yan X, Zhang H, et al. Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. J Biol Chem 2002, 277:6088-6096.
11. Mirshahi T, Robillard L, Zhang H, et al. Gbeta residues that do not interact with Galpha underlie agonist-independent activity of K+ channels. J Biol Chem 2002, 277:7348-7355.
12. Doupnik CA, Davidson N, Lester HA, Kofuji P RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A 1997, 94:10461-10466.
13. Ma JY, Catterall WA, Scheuer T Persistent sodium currents through brain sodium channels induced by G protein betagamma subunits. Neuron 1997, 19:443-452.
14. Santoro B, Grant SG, Bartsch D, Kandel ER Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A 1997, 94:14815-14820.
15. Santoro B, Liu DT, Yao H, et al. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 1998, 93:717-729.
16. Ludwig A, Zong X, Jeglitsch M, et al. A family of hyperpolarization-activated mammalian cation channels. Nature 1998, 393:587-591.
17. Gauss R, Seifert R, Kaupp UB Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature 1998, 393:583-587.
18. Clapham DE Not so funny anymore: Pacing channels are cloned. Neuron 1998, 21:5-7.
19. Moroni A, Gorza L, Beltrame M, et al. Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f). J Biol Chem 2001, 276:29233-29241.
20. Shi W, Wymore R, Yu H, et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res 1999, 85:e1-e6.
21. Vaccari T, Moroni A, Rocchi M, et al. The human gene coding for HCN2, a pacemaker channel of the heart. Biochim Biophys Acta 1999, 1446:419-425.
22. Ludwig A, Zong X, Stieber J, et al. Two pacemaker channels from human heart with profoundly different activation kinetics. EMBO J 1999, 18:2323-2329.
23. Kaupp UB, Niidome T, Tanabe T, et al. Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel. Nature 1989, 342:762-766.
24. Kaupp UB, Seifert R Molecular diversity of pacemaker ion channels. Annu Rev Physiol 2001, 63:235-257.
25. DiFrancesco D, Tortora P Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature 1991, 351:145-147.
26. Wainger BJ, DeGennaro M, Santoro B, et al. Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature 2001, 411:805-810.
27. Mikami A, Imoto K, Tanabe T, et al. Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature 1989, 340:230-233.
28. Wakamori M, Mikala G, Schwartz A, Yatani A Single-channel analysis of a cloned human heart L-type Ca2+ channel alpha 1 subunit and the effects of a cardiac beta subunit. Biochem Biophys Res Commun 1993, 196:1170-1176.
29. Yang J, Ellinor PT, Sather WA, et al. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature 1993, 366:158-161.
30. Hersel J, Jung S, Mohacsi P, Hullin R Expression of the L-type calcium channel in human heart failure. Basic Res Cardiol 2002, 97:I4-I10.
31. Hulme JT, Ahn M, Hauschka SD, et al. A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. J Biol Chem 2002, 277:4079-4087.
32. Splawski I, Shen J, Timothy KW, et al. Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Genomics 1998, 51:86-97.
33. Marx SO, Kurokawa J, Reiken S, et al. Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 2002, 295:496-499.
34. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 1995, 269:92-95.
35. Warmke JW, Ganetzky B A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci U S A 1994, 91:3438-3442.
36. January CT, Gong Q, Zhou Z Long QT syndrome: Cellular basis and arrhythmia mechanism in LQT2. J Cardiovasc Electrophysiol 2000, 11:1413-1418.
37. Miller C The inconstancy of the human heart. Nature 1996, 379:767-768.
38. Tseng GN I(Kr): The HERG channel. J Mol Cell Cardiol 2001, 33:835-849.
39. del Camino D, Holmgren M, Liu Y, Yellen G Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature 2000, 403:321-325.
40. Mitcheson JS, Chen J, Sanguinetti MC Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol 2000, 115:229-240.
41. Mitcheson JS, Chen J, Lin M, et al. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A 2000, 97:12329-12333.
42. Morais Cabral JH, Lee A, Cohen SL, et al. Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain. Cell 1998, 95:649-655.
43. Chen J, Zou A, Splawski I, et al. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem 1999, 274:10113-10118.
44. Kiehn J Regulation of the cardiac repolarizing HERG potassium channel by protein kinase A. Trends Cardiovasc Med 2000, 10:205-209.
45. Kiehn J, Karle C, Thomas D, et al. HERG potassium channel activation is shifted by phorbol esters via protein kinase A-dependent pathways. J Biol Chem 1998, 273:25285-25291.
46. Bian J, Cui J, McDonald TV HERG K(+) channel activity is regulated by changes in phosphatidyl inositol 4,5-bisphosphate. Circ Res 2001, 89:1168-1176.
47. Roti EC, Myers CD, Ayers RA, et al. Interaction with GM130 during HERG ion channel trafficking: Disruption by type 2 congenital long QT syndrome mutations-Human ether-a-go-go-related gene. J Biol Chem 2002, 277:47779-47785.
48. Antzelevitch C Molecular biology and cellular mechanisms of Brugada and long QT syndromes in infants and young children. J Electrocardiol 2001, 34:177-181.
49. Viswanathan PC, Bezzina CR, George AL, et al. Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes. Circulation 2001, 104:1200-1205.
50. Isom LL, De Jongh KS, Catterall WA Auxiliary subunits of voltage-gated ion channels. Neuron 1994, 12:1183-1194.
51. Balser JR The cardiac sodium channel: Gating function and molecular pharmacology. J Mol Cell Cardiol 2001, 33:599-613.
52. Tan HL, Kupershmidt S, Zhang R, et al. A calcium sensor in the sodium channel modulates cardiac excitability. Nature 2002, 415:442-447.
53. Tang W, Sencer S, Hamilton SL Calmodulin modulation of proteins involved in excitation-contraction coupling. Front Biosci 2002, 7:d1583-d1589.
54. Peterson BZ, Lee JS, Mulle JG, et al. Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels. Biophys J 2000, 78:1906-1920.
55. Zuhlke RD, Pitt GS, Deisseroth K, et al. Calmodulin supports both inactivation and facilitation of L-type calcium channels. Nature 1999, 399:159-162.
56. Holm AN, Rich A, Miller SM, et al. Sodium current in human jejunal circular smooth muscle cells. Gastroenterology 2002, 122:178-187.
57. Gee SH, Madhavan R, Levinson SR, et al. Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. J Neurosci 1998, 18:128-137.
58. Ou Y, Strege P, Miller SM, et al. Syntrophin gamma 2 regulates SCN5A gating by a PDZ domain-mediated interaction. J Biol Chem 2003, 278:1915-1923.
59. Schultz J, Hoffmuller U, Krause G, et al. Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat Struct Biol 1998, 5:19-24.
60. Ahn AH, Yoshida M, Anderson MS, et al. Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24. Proc Natl Acad Sci U S A 1994, 91:4446-4450.
61. Ahn AH, Kunkel LM Syntrophin binds to an alternatively spliced exon of dystrophin. J Cell Biol 1995, 128:363-371.
62. Blake DJ, Weir A, Newey SE, Davies KE Function and genetics of dystrophin and dystrophin-related proteins in muscle. Physiol Rev 2002, 82:291-329.
63. Suzuki A, Yoshida M, Ozawa E Mammalian alpha 1- and beta 1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus. J Cell Biol 1995, 128:373-381.
64. Piluso G, Mirabella M, Ricci E, et al. Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. J Biol Chem 2000, 275:15851-15860.
65. Ahn AH, Freener CA, Gussoni E, et al. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem 1996, 271:2724-2730.