Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD

Pulmonary Pharmacology and Therapeutics

Volumn 28, Issue 2, 2014, Pages 138-148

  Milara, Javier ^a,b,c   Peiró, Teresa ^c,d   Serrano, Adela ^c,e   Guijarro, Ricardo ^a,d   Zaragozá, Cristóbal ^a   Tenor, Herman ^f   Cortijo, Julio ^a,c,d,e  

^a HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^b UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^c Research Foundation of General Hospital of Valencia   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f Takeda Pharmaceuticals International GmbH   (Switzerland)

Author keywords

COPD; Epithelial to mesenchymal transition; Roflumilast

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CIGARETTE SMOKE; COLLAGEN TYPE 1; CYCLIC AMP; FLUORESCEIN; KRT5 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN ZO1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; ROFLUMILAST; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; AMINOPYRIDINE DERIVATIVE; BENZAMIDE DERIVATIVE; CYCLOPROPANE DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST N-OXIDE; SMOKE;

ADULT; AGED; APOPTOSIS ASSAY; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IN VITRO STUDY; LUNG FUNCTION; MALE; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SMOKING; ADVERSE EFFECTS; APOPTOSIS; BRONCHUS; CYTOLOGY; DRUG EFFECTS; METABOLISM; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY TRACT MUCOSA; SMOKE;

AGED; AMINOPYRIDINES; APOPTOSIS; BENZAMIDES; BRONCHI; CYCLIC AMP; CYCLOPROPANES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; IN VITRO TECHNIQUES; MALE; MIDDLE AGED; PHOSPHODIESTERASE 4 INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA; SMOKE; SMOKING; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84904112633     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2014.02.001     Document Type: Article

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