Cigarette smoke-induced failure of apoptosis resulting in enhanced neoplastic transformation in human bronchial epithelial cells

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 75, Issue 12, 2012, Pages 707-720

  Du, Houbing ^a   Sun, Jing ^a   Chen, Zhihai ^a   Nie, Jihua ^a   Tong, Jian ^a   Li, Jianxiang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

APOPTOSIS; ARTICLE; BRONCHIAL EPITHELIAL CELL; CARCINOGENICITY; CELL GROWTH; CELL TRANSFORMATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BRONCHI; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA METHYLATION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED BALB C; NEOPLASMS; PROMOTER REGIONS, GENETIC; RESPIRATORY MUCOSA; RNA, MESSENGER; SMOKING;

EID: 84863675904     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2012.690088     Document Type: Article

References (58)

1. Agathanggelou, A., Cooper, W. N., and Latif, F. 2005. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 65: 3497-508.
2. Ahmedin, J., Siegel, R., and Ward, E. M. 2010. Global cancer facts & figures 2010. Atlanta, GA: American Cancer Society.
3. Armstrong J. S. 2006. Mitochondrial membrane permeabilization: The sine qua non for cell death. Bioessays 28: 253-60.
4. Baksh, S., Tommasi, S., Fenton, S., Yu, V. C., Martins, M., Pfeifer, G. P., Latif, F., Downward, J., and Neel, B. G. 2005. The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. Mol. Cell 18: 637-50.
5. Baumgartner, K. B., Samet, J. M., Doultas, D. B., Stidley, C. A., Hunt, W. C., Colby, T. V., Waldron, J. A., and Centers, C. 2000. Occupational and environmental risk factors for idiopathic pulmonary fibrosis: A multicenter case-control study. Am. J. Epidemiol 15: 307-15.
6. Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., and Issa, J. P. 1998 Alterations in DNA methylation: A fundamental aspect of neoplasia. Adv. Cancer Res. 72: 141-96.
7. Beier, D., Röhrl, S., Pillai, D. R., Schwarz, S., Kunz-Schughart, L. A., Leukel, P., Proescholdt, M., Brawanski, A., Bogdahn, U., Trampe-Kieslich, A., Giebel, B., Wischhusen, J., Reifenberger, G., Haul, P., and Beier, C.P. 2008. Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 68: 5706-15.
8. Belinsky, S. A., Palmisano, W. A., Gilliland, F. D., Crooks, L. A., Divine, K. K., Winters, S. A., Grimes, M. J., Harms, H. J., Tellez, C. S., Smith, T. M., Moots P.P., Lechner, J. F., and Stidley, C. A. 2002. Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res. 62: 2370-77.
9. Burbee, D. G., Forgacs, E., Zöchbauer-M'ller, S., Shivakumar, L., Fong, K., Gao, B., Randle, D., Kondo, M., Virmani, A., and Bader, S. 2001. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. JNCI 93: 691-99.
10. Curvall, M., Enzell, C.R., Jansson, T., Pettersson, B. and Thelestam, M. 1984. Evaluation of the biological activity of cigarette-smoke condensate fractions using six in vitro short-term tests. J. Toxicol. Environ. Health 14: 163-80.
11. Dallol, A., Agathanggelou, A., Tommasi, S., Pfeifer, G. P., Maher, E. R. and Latif, F. 2005. Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res. 65: 7653-59.
12. Dammann, R., Li, C., Yoon, J. H., Chin, P. L., Bates, S., and Pfeifer, G. P. 2000. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat. Genet. 25: 315-19.
13. Damps, I., Jassem, E., and Sieminska, A. 2001. Molecular basis of carcinogenesis in lung cancer induced by cigarette smoking. Pol. Merkur Lekarski 10: 403-4.
14. Dasgupta, P., Kinkade, R., Joshi, B., DeCook, C., Haura, E., and Chellappan, S. 2006. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc. Natl. Acad. Sci. USA 103: 6332-37.
15. Divine, K. K., Pulling, L. C., Marron-Terada, P. G., Liechty, K. C., Kang, T., Schwartz, A. G., Bocklage, T. J., Coons, T. A., Gilliland, F. D., and Belinsky, S. A. 2005. Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers. Int. J. Cancer 114: 400-5.
16. Dubal, D. B., Shughrue, P. J., Wilson, M. E., Merchenthaler, I., and Wise, P. M. 1999. Estradiol modulates Bcl-2 in cerebral ischemia: A potential role for estrogen receptors. J. Neurosci. 19: 6385-93.
17. Esteller, M., Hamilton, S. R., Burger, P. C., Baylin, S. B., and Herman, J. G. 1999. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59: 793-97.
18. Esteller, M., Toyota,M., Sanchez-Cespedes, ., Capella, G., Peinado, M. A., Watkins, D. N., Issa J. J., Sidransky, D., Baylin, S. B., and Herman, J. G. 2000. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res. 60: 2368-71.
19. Foubert, P., Silvestre, J. S., Souttou, B., Barateau, V., Martin, C., Ebrahimian, T. G., Leré-Déan, C., Contreres, J. O., Sulpice, E., Levy, B. I., Plou't, J., Tobelem, G., and Le Ricousse-Roussanne, S. 2007. PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells. J. Clin. Invest. 117: 1527-37.
20. Grafstrom, R. C., Dypbukt, J. M., Willey, J. C., Sundqvist, K., Edman, C., Atzori, L., and Harris, C. C. 1988. Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res. 48: 1717-21.
21. Green, D. R. and Reed, J. C. 1998. Mitochondria and apoptosis. Science 281: 1309-11.
22. Guha, M., Plescia, J. Leav, I., Li, J., Languino, L. R., and Altieri, D. C. 2009. Endogenous tumor suppression mediated by PTEN involves survivin gene silencing. Cancer Res. 69: 4954-58.
23. Hahn, F. F., Gigliotti, A. P., Hutt, J. A., March, T. H., and Mauderly, J. L. 2007. A review of the histopathology of cigarette smoke-induced lung cancer in rats and mice. Int. J. Toxicol. 26: 307-13.
24. Hanahan, D., and Weinberg, R. 2011. Hallmarks of cancer: The next generation. Cell 144: 466-74.
25. Hecht, S. S. 1999. Tobacco smoke carcinogens and lung cancer. JNCI 91: 1194-210.
26. Hecht, S. S. 2005. Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: Old and new. Carcinogenesis 26: 1488-92.
27. Herman, J. G., Graff, J. R., Myöhänen, S., Nelkin, B. D., and Baylin, S. B. 1996.Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. U.S.A 93: 9821-26.
28. Herman, J. G., 1999. Hypermethylation of tumor suppressor genes in cancer. Semin Cancer Biol. 9: 359-67.
29. Herman, J. G., and Baylin, S. B. 2003. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349: 2042-54.
30. Hoffmann, D., and Hoffmann, I. 1997. The changing cigarette, 1950-1995. J. Toxicol. Environ. Health 50: 307-64.
31. Hu, Y. C., Yang, Z. H., Zhong, K. J., Niu, L. J., Pan, X. J., Wu, D. C., Sun, X. J., Zhou, P. K., Zhu, M. X., and Huo, Y. Y. 2009. Alteration of transcriptional profile in human bronchial epithelial cells induced by cigarette smoke condensate. Toxicol. Lett. 190: 23-31.
32. Jones, P. A., and Baylin, S. B. 2002. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3: 415-28.
33. Kren, L., Brazdil, J., Hermanova, M., Goncharuk, V. N., Kallakury, B. V., Kaur, P., and Ross, J. S. 2004. Prognostic significance of anti-apoptosis proteins surviving and bcl-2 in non-small cell lung carcinomas a clinicopathologic study of 102 cases. Appl. Immunohistochem Mol. Morphol. 12: 44-49.
34. Kroemer, G., Zamzami, N., and Susin, S. A. 1997. Mitochondrial control of apoptosis. Immunol. Today 18: 44-51.
35. Kuroki, T., Trapasso, F., Yendamuri, S., Matsuyama, A., Alder, H., Mori, M., and Croce, C. M., 2003. Promoter hypermethylation of RASSF1A in esophageal squamous cell carcinoma. Clin. Cancer 9: 1441-45.
36. Lafyatis, R., Remmers, E. F., Roberts, A. B., Yocum, D. E., Sporn, M. B., and Wilder, R. L. 1989. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83: 1267-76.
37. Lin, R. K., Hsieh, Y. S., Lin, P., Hsu, H. S., Chen, C. Y., Tang, Y. A., Lee, C. F., andWang, Y. C. 2010. The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients. J. Clin. Invest. 120: 521-32.
38. Liu, Y., Lan, Q., Siegfried, J. M., Luketich, J., D., and Keohavong, P. 2005. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and neversmoking lung cancer patients. Neoplasia 8: 46-51.
39. Malyankar, U. M., and MacDougall, J. R. 2004. Genome-scale analysis of lung cancer progression. Pharmacogenomics 4: 169-76.
40. Minna, J. D., Roth, J. A., and Gazdar, A. F. 2002. Focus on lung cancer. Cancer Cell 1: 49-52.
41. Ortiz-Vega, S., Khokhlatchev, A., Nedwidek, M., Zhang, X. F., Dammann, R., Pfeifer, G. P., and Avruch, J. 2002. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore 1. Oncogene 21: 3225-28.
42. Pegg, A. E. 2000. Repair of O(6)-alkylguanine by alkyltransferases. Mutat. Res. 462: 83-100.
43. Peterson, L. A., Thomson, N. M., Crankshaw, D. L., Donaldson, E. E., and Kenney, P. J., 2001. Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone-induced lung tumorigenesis. Cancer Res. 61: 5757-63.
44. Powell, C. A., Bueno, R., Borczuk, A. C., Caracta, C. F., Richards, W. G., Sugarbaker, D. J., and Brody, J. S. 2003. Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers. Lung Cancer 39: 23-29.
45. Santiago, L. N., de Camargo Juliana, F., Braga L. N., and Cury, P. M. 2009. The effect of different doses of cigarette smoke in a mouse lung tumor model. Int. J. Clin. Exp. Pathol. 2: 176-81.
46. Stennicke, H. R., and Salvesen, G. S. 2000. Caspases-controlling intracellular signals by protease zymogen activation. Biochim. Biophys. Acta 1477: 299-306.
47. Suzuki, A., Ito, T., Kawano, H., Hayashida, M., Hayasaki, Y., Tsutomi, Y., kahane, K., Nakano, A., Miura, M., and Shiraki, K. 2000. Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death. Oncogene 19: 1346-53.
48. Tomizawa, Y., Kohno, T., Kondo, H., Otsuka, A., Nishioka, M., Niki, T., Yamada, T.,Maeshima, A., Yoshimura, K., Saito, R., Minna J.D., and Yokota J. 2002. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin. Cancer Res. 8: 2362-68.
49. Veljkovic, E., Jiricny, J., Menigatti,M., Rehrauer, H., and Han W. J. 2011. Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol. In Vitro 25: 446-53.
50. Vischioni, B., Van der, V. P., Span, S. W., Kruyt, F. A., Rodriguez, J. A., and Giaccone, G. 2004. Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancer. Ann. Oncol. 15: 1654-60.
51. Vos, M. D., Ellis, C. A., Bell, A., Birrer, M. J., and Clark, G. J. 2000. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J. Biol. Chem. 275: 35669-72.
52. Wiencke, J. K. 2002. DNA adduct burden and tobacco carcinogenesis. Oncogene 21: 7376-91.
53. Xu, J., Huang, H., Pan, C., Zhang, B., Liu, X., and Zhang, L. 2007. Nicotine inhibits apoptosis induced by cisplatin in human oral cancer cells. Int. J. Oral Maxillofacial Surg. 36: 739-44.
54. Xu, A., Prophete, C., Chem, L. C., Emala, C. W., and Cohen, M. D. 2011. Interactive effect of cigarette smoke extract and World Trade Center dust particles on airway cell cytotoxicity. J. Toxicol. Environ. Health A 74: 887-902.
55. Zambrano, P., Segura-Pacheco, B., Perez-Cardenas, E., Duenas-González, A., Cetina, L., Revilla-Vazquez, A., Taja-Chayeb, L., Angeles, E., Cabrera, G., and Sandoval, K. 2005. A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer 5.
56. Zamzami, N.,Marchetti, P., Castedo, M., Zanin, C., Vayssiere, J. L., Petit, P. X., and Kroemer, G. 1995. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181: 1661-72.
57. Zhang, T., Lu, H., Shang, X., Tian, Y. H., Zheng, C. Y., Wang, S. W., Cheng, H. H.,and Zhou, R. J. 2006. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochem. Biophs. Res. Commun. 342: 928-34.
58. Zhang, T., Lu, H., Shang, X., Tian, Y. H., Zheng, C. Y., Wang, S. W., Cheng, H. H.,and Zhou, R. J. 2006. Nicotine prevents the apoptosis induced by menadione in human lung cancer cells. Biochem. Biophs. Res. Commun. 342: 928-34.