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Volumn 34, Issue 6, 2014, Pages 467-477

Systematic review and meta-analysis of the bone protective effect of phytoestrogens on osteoporosis in ovariectomized rats

Author keywords

Bone histomorphometric parameters; Bone mineral density; Bone turnover markers; Meta analysis; Osteoporosis; Ovariecomized rat; Phytoestrogens

Indexed keywords

ACHYRANTHES BIDENTATA EXTRACT; ALKALINE PHOSPHATASE; APIGENIN; CISSUS QUADRANGULARIS EXTRACT; EUCOMMIA ULMOIDES EXTRACT; FERUTININ; GENISTEIN; GINKGO BILOBA EXTRACT; ICARIIN; ISOFLAVONE; ONOBRYCHIS EBENOIDES EXTRACT; OSTEOCALCIN; PHYTOESTROGEN; PLANT EXTRACT; PRUNELLA VULGARIS EXTRACT; UNCLASSIFIED DRUG;

EID: 84904104282     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.05.003     Document Type: Review
Times cited : (44)

References (72)
  • 1
    • 77953393581 scopus 로고    scopus 로고
    • Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III
    • Looker A.C., Melton L.J., Harris T.B., Borrud L.G., Shepherd J.A. Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III. J Bone Miner Res 2010, 25:64-71.
    • (2010) J Bone Miner Res , vol.25 , pp. 64-71
    • Looker, A.C.1    Melton, L.J.2    Harris, T.B.3    Borrud, L.G.4    Shepherd, J.A.5
  • 2
    • 84991652336 scopus 로고    scopus 로고
    • Reference values of bone mineral density and prevalence of osteoporosis in Chinese adults
    • Zhang Z.Q., Ho S.C., Chen Z.Q., Zhang C.X., Chen Y.M. Reference values of bone mineral density and prevalence of osteoporosis in Chinese adults. Osteoporos Int 2013, 67:321-331.
    • (2013) Osteoporos Int , vol.67 , pp. 321-331
    • Zhang, Z.Q.1    Ho, S.C.2    Chen, Z.Q.3    Zhang, C.X.4    Chen, Y.M.5
  • 3
    • 0029783770 scopus 로고    scopus 로고
    • Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis
    • Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 1996, 11:1043-1051.
    • (1996) J Bone Miner Res , vol.11 , pp. 1043-1051
    • Pacifici, R.1
  • 4
    • 79954619872 scopus 로고    scopus 로고
    • Current and future treatment options in osteoporosis
    • Brewer L., Williams D., Moore A. Current and future treatment options in osteoporosis. Eur J Clin Pharmacol 2011, 67:321-331.
    • (2011) Eur J Clin Pharmacol , vol.67 , pp. 321-331
    • Brewer, L.1    Williams, D.2    Moore, A.3
  • 5
    • 0032093690 scopus 로고    scopus 로고
    • Cytokines, estrogen, and postmenopausal osteoporosis-the second decade
    • Pacifici R. Cytokines, estrogen, and postmenopausal osteoporosis-the second decade. Endocrinology 1998, 139:2659-2661.
    • (1998) Endocrinology , vol.139 , pp. 2659-2661
    • Pacifici, R.1
  • 6
    • 0038167811 scopus 로고    scopus 로고
    • Relationship between long durations and different regimens of hormone therapy and risk of breast cancer
    • Li C.I., Malone K.E., Porter P.L., Weiss N.S., Tang M.T., Cushing-Haugen K.L., et al. Relationship between long durations and different regimens of hormone therapy and risk of breast cancer. JAMA 2003, 289:3254-3263.
    • (2003) JAMA , vol.289 , pp. 3254-3263
    • Li, C.I.1    Malone, K.E.2    Porter, P.L.3    Weiss, N.S.4    Tang, M.T.5    Cushing-Haugen, K.L.6
  • 7
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3    LaCroix, A.Z.4    Kooperberg, C.5    Stefanick, M.L.6
  • 8
    • 35748982440 scopus 로고    scopus 로고
    • The spectrum of phytoestrogens in nature: our knowledge is expanding
    • Moutsatsou P. The spectrum of phytoestrogens in nature: our knowledge is expanding. Hormones (Athens) 2007, 6:173-193.
    • (2007) Hormones (Athens) , vol.6 , pp. 173-193
    • Moutsatsou, P.1
  • 10
    • 33751158078 scopus 로고
    • Isoflavone content in commercial soybean foods
    • Wang H., Murphy P.A. Isoflavone content in commercial soybean foods. J Agric Food Chem 1994, 42:1666-1673.
    • (1994) J Agric Food Chem , vol.42 , pp. 1666-1673
    • Wang, H.1    Murphy, P.A.2
  • 12
    • 80052566343 scopus 로고    scopus 로고
    • Osteoprotective effect of Monascus-fermented Dioscorea in ovariectomized rat model of postmenopausal osteoporosis
    • Chiang S.S., Chang S.P., Pan T.M. Osteoprotective effect of Monascus-fermented Dioscorea in ovariectomized rat model of postmenopausal osteoporosis. J Agric Food Chem 2011, 59:9150-9157.
    • (2011) J Agric Food Chem , vol.59 , pp. 9150-9157
    • Chiang, S.S.1    Chang, S.P.2    Pan, T.M.3
  • 13
    • 33748188128 scopus 로고    scopus 로고
    • Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    • Thompson L.U., Boucher B.A., Liu Z., Cotterchio M., Kreiger N. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Nutr Cancer 2006, 54:184-201.
    • (2006) Nutr Cancer , vol.54 , pp. 184-201
    • Thompson, L.U.1    Boucher, B.A.2    Liu, Z.3    Cotterchio, M.4    Kreiger, N.5
  • 14
    • 0035181619 scopus 로고    scopus 로고
    • High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women
    • Mei J., Yeung S.S., Kung A.W. High dietary phytoestrogen intake is associated with higher bone mineral density in postmenopausal but not premenopausal women. J Clin Endocrinol Metab 2001, 86:5217-5221.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5217-5221
    • Mei, J.1    Yeung, S.S.2    Kung, A.W.3
  • 15
    • 0035161868 scopus 로고    scopus 로고
    • Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women
    • Somekawa Y., Chiguchi M., Ishibashi T., Aso T. Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 2001, 97:109-115.
    • (2001) Obstet Gynecol , vol.97 , pp. 109-115
    • Somekawa, Y.1    Chiguchi, M.2    Ishibashi, T.3    Aso, T.4
  • 16
    • 25144490031 scopus 로고    scopus 로고
    • Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
    • Zhang X., Shu X.O., Li H., Yang G., Li Q., Gao Y.T., et al. Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women. Arch Intern Med 2005, 165:1890-1895.
    • (2005) Arch Intern Med , vol.165 , pp. 1890-1895
    • Zhang, X.1    Shu, X.O.2    Li, H.3    Yang, G.4    Li, Q.5    Gao, Y.T.6
  • 17
    • 0348107337 scopus 로고    scopus 로고
    • Dietary phyto-oestrogens and bone health
    • Branca F. Dietary phyto-oestrogens and bone health. Proc Nutr Soc 2003, 62:877-887.
    • (2003) Proc Nutr Soc , vol.62 , pp. 877-887
    • Branca, F.1
  • 18
    • 33645000494 scopus 로고    scopus 로고
    • Pharmaceutical prospects of phytoestrogens
    • Usui T. Pharmaceutical prospects of phytoestrogens. Endocr J 2006, 53:7-20.
    • (2006) Endocr J , vol.53 , pp. 7-20
    • Usui, T.1
  • 20
    • 84873087277 scopus 로고    scopus 로고
    • Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women
    • Anderson L.N., Cotterchio M., Boucher B.A., Kreiger N. Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. Int J Cancer 2013, 132:1683-1692.
    • (2013) Int J Cancer , vol.132 , pp. 1683-1692
    • Anderson, L.N.1    Cotterchio, M.2    Boucher, B.A.3    Kreiger, N.4
  • 22
    • 1442311168 scopus 로고    scopus 로고
    • Where is the evidence that animal research benefits humans?
    • Pound P., Ebrahim S., Sandercock P., Bracken M.B., Roberts I. Where is the evidence that animal research benefits humans?. BMJ 2004, 328:514-517.
    • (2004) BMJ , vol.328 , pp. 514-517
    • Pound, P.1    Ebrahim, S.2    Sandercock, P.3    Bracken, M.B.4    Roberts, I.5
  • 23
    • 2142768247 scopus 로고    scopus 로고
    • Pooling of animal experimental data reveals influence of study design and publication bias
    • Macleod M.R., O'Collins T., Howells D.W., Donnan G.A. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 2004, 35:1203-1208.
    • (2004) Stroke , vol.35 , pp. 1203-1208
    • Macleod, M.R.1    O'Collins, T.2    Howells, D.W.3    Donnan, G.A.4
  • 24
    • 20044384887 scopus 로고    scopus 로고
    • The need for systematic reviews of animal studies
    • Roberts C., Pound P. The need for systematic reviews of animal studies. Chin J Evid Based Med 2005, 5:3-4.
    • (2005) Chin J Evid Based Med , vol.5 , pp. 3-4
    • Roberts, C.1    Pound, P.2
  • 25
    • 77955982322 scopus 로고    scopus 로고
    • Effects of soy isoflavone supplements on bone turnover markers in menopausal women: systematic review and meta-analysis of randomized controlled trials
    • Taku K., Melby M.K., Kurzer M.S., Mizuno S., Watanabe S., Ishimi Y. Effects of soy isoflavone supplements on bone turnover markers in menopausal women: systematic review and meta-analysis of randomized controlled trials. Bone 2010, 47:413-423.
    • (2010) Bone , vol.47 , pp. 413-423
    • Taku, K.1    Melby, M.K.2    Kurzer, M.S.3    Mizuno, S.4    Watanabe, S.5    Ishimi, Y.6
  • 26
    • 63849105841 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)
    • Available from, J.P.T. Higgins, S. Green (Eds.)
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration 2011, [p. Available from www.cochrane-handbook.org]. J.P.T. Higgins, S. Green (Eds.).
    • (2011) The Cochrane Collaboration
  • 27
  • 28
    • 84873430391 scopus 로고    scopus 로고
    • Atherosclerosis prevention by nutritional factors: a meta-analysis in small animal models
    • Jove M., Pamplona R., Prat J., Arola L., Portero-Otin M. Atherosclerosis prevention by nutritional factors: a meta-analysis in small animal models. Nutr Metab Cardiovasc Dis 2013, 23:84-93.
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 84-93
    • Jove, M.1    Pamplona, R.2    Prat, J.3    Arola, L.4    Portero-Otin, M.5
  • 29
    • 34548321765 scopus 로고    scopus 로고
    • The selection of a summary statistic for use in meta-analysis
    • Wen J., Li Y.P. The selection of a summary statistic for use in meta-analysis. Chin J Evid Based Med 2007, 7:606-613.
    • (2007) Chin J Evid Based Med , vol.7 , pp. 606-613
    • Wen, J.1    Li, Y.P.2
  • 30
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M., Davey Smith G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 31
    • 84861856683 scopus 로고    scopus 로고
    • Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats
    • Aswar U.M., Mohan V., Bodhankar S.L. Antiosteoporotic activity of phytoestrogen-rich fraction separated from ethanol extract of aerial parts of Cissus quadrangularis in ovariectomized rats. Indian J Pharmacol 2012, 44:345-350.
    • (2012) Indian J Pharmacol , vol.44 , pp. 345-350
    • Aswar, U.M.1    Mohan, V.2    Bodhankar, S.L.3
  • 32
    • 0141638672 scopus 로고    scopus 로고
    • Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone
    • 597-595
    • Breitman P.L., Fonseca D., Cheung A.M., Ward W.E. Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone. Bone 2003, 33:597-5.
    • (2003) Bone , vol.33
    • Breitman, P.L.1    Fonseca, D.2    Cheung, A.M.3    Ward, W.E.4
  • 33
  • 34
    • 84870806840 scopus 로고    scopus 로고
    • Combined effect of soy isoflavones and vitamin D3 on bone loss in ovariectomized rats
    • Chang K.L., Hu Y.C., Hsieh B.S., Cheng H.L., Hsu H.W., Huang L.W., et al. Combined effect of soy isoflavones and vitamin D3 on bone loss in ovariectomized rats. Nutrition 2013, 29:250-257.
    • (2013) Nutrition , vol.29 , pp. 250-257
    • Chang, K.L.1    Hu, Y.C.2    Hsieh, B.S.3    Cheng, H.L.4    Hsu, H.W.5    Huang, L.W.6
  • 35
    • 46849116642 scopus 로고    scopus 로고
    • Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats
    • Dai R., Ma Y., Sheng Z., Jin Y., Zhang Y., Fang L., et al. Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats. J Bone Miner Metab 2008, 26:342-349.
    • (2008) J Bone Miner Metab , vol.26 , pp. 342-349
    • Dai, R.1    Ma, Y.2    Sheng, Z.3    Jin, Y.4    Zhang, Y.5    Fang, L.6
  • 37
    • 29244487579 scopus 로고    scopus 로고
    • Protective effect of plant extract from Onobrychis ebenoides on ovariectomy-induced bone loss in rats
    • Dontas I., Halabalaki M., Moutsatsou P., Mitakou S., Papoutsi Z., Khaldi L., et al. Protective effect of plant extract from Onobrychis ebenoides on ovariectomy-induced bone loss in rats. Maturitas 2006, 53:234-242.
    • (2006) Maturitas , vol.53 , pp. 234-242
    • Dontas, I.1    Halabalaki, M.2    Moutsatsou, P.3    Mitakou, S.4    Papoutsi, Z.5    Khaldi, L.6
  • 38
    • 77954116922 scopus 로고    scopus 로고
    • Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis
    • Ferretti M., Bertoni L., Cavani F., Zavatti M., Resca E., Carnevale G., et al. Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis. J Anat 2010, 217:48-56.
    • (2010) J Anat , vol.217 , pp. 48-56
    • Ferretti, M.1    Bertoni, L.2    Cavani, F.3    Zavatti, M.4    Resca, E.5    Carnevale, G.6
  • 39
    • 84868317562 scopus 로고    scopus 로고
    • Effects of fermented black soybean pulp on lipid and bone metabolism in ovariectomized rats
    • 1397-1303
    • Hong G.E., Pyun C.W., Kim S.K., Han K.H., Yang C.Y., Lee C.H. Effects of fermented black soybean pulp on lipid and bone metabolism in ovariectomized rats. Food Sci Biotechnol 2012, 21:1397-03.
    • (2012) Food Sci Biotechnol , vol.21
    • Hong, G.E.1    Pyun, C.W.2    Kim, S.K.3    Han, K.H.4    Yang, C.Y.5    Lee, C.H.6
  • 40
    • 77958171184 scopus 로고    scopus 로고
    • Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormone deficiency
    • Hooshmand S., Juma S., Arjmandi B.H. Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormone deficiency. J Med Food 2010, 13:320-325.
    • (2010) J Med Food , vol.13 , pp. 320-325
    • Hooshmand, S.1    Juma, S.2    Arjmandi, B.H.3
  • 41
    • 79959753195 scopus 로고    scopus 로고
    • Effects of cheonggukjang containing arrowroot isoflavones on bone metabolism in ovariectomized rats
    • Lee M.Y., Chang K.H. Effects of cheonggukjang containing arrowroot isoflavones on bone metabolism in ovariectomized rats. Food Sci Biotechnol 2011, 20:335-341.
    • (2011) Food Sci Biotechnol , vol.20 , pp. 335-341
    • Lee, M.Y.1    Chang, K.H.2
  • 42
    • 62549091847 scopus 로고    scopus 로고
    • Antiosteoporotic activity of icariin in ovariectomized rats
    • Nian H., Ma M.H., Nian S.S., Xu L.L. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 2009, 16:320-326.
    • (2009) Phytomedicine , vol.16 , pp. 320-326
    • Nian, H.1    Ma, M.H.2    Nian, S.S.3    Xu, L.L.4
  • 43
    • 84862958127 scopus 로고    scopus 로고
    • Effects of Cheonnyuncho (Opuntia humifusa) seeds treatment on the mass, quality, and the turnover of bone in ovariectomized rats
    • Park J., Hahm S.W., Son Y.S. Effects of Cheonnyuncho (Opuntia humifusa) seeds treatment on the mass, quality, and the turnover of bone in ovariectomized rats. Food Sci Biotechnol 2011, 20:1517-1524.
    • (2011) Food Sci Biotechnol , vol.20 , pp. 1517-1524
    • Park, J.1    Hahm, S.W.2    Son, Y.S.3
  • 44
    • 44649178200 scopus 로고    scopus 로고
    • Protective effect of apigenin on ovariectomy-induced bone loss in rats
    • Park J.A., Ha S.K., Kang T.H., Oh M.S., Cho M.H., Lee S.Y., et al. Protective effect of apigenin on ovariectomy-induced bone loss in rats. Life Sci 2008, 82:1217-1223.
    • (2008) Life Sci , vol.82 , pp. 1217-1223
    • Park, J.A.1    Ha, S.K.2    Kang, T.H.3    Oh, M.S.4    Cho, M.H.5    Lee, S.Y.6
  • 45
    • 67649873336 scopus 로고    scopus 로고
    • Osteoprotective effect of Phaseolus vulgaris L in ovariectomy-induced osteopenia in rats
    • Shirke S.S., Jadhav S.R., Jagtap A.G. Osteoprotective effect of Phaseolus vulgaris L in ovariectomy-induced osteopenia in rats. Menopause 2009, 16:589-596.
    • (2009) Menopause , vol.16 , pp. 589-596
    • Shirke, S.S.1    Jadhav, S.R.2    Jagtap, A.G.3
  • 46
    • 60549096618 scopus 로고    scopus 로고
    • Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol
    • Trivedi R., Kumar A., Gupta V., Kumar S., Nagar G.K., Romero J.R., et al. Effects of Egb 761 on bone mineral density, bone microstructure, and osteoblast function: possible roles of quercetin and kaempferol. Mol Cell Endocrinol 2009, 302:86-91.
    • (2009) Mol Cell Endocrinol , vol.302 , pp. 86-91
    • Trivedi, R.1    Kumar, A.2    Gupta, V.3    Kumar, S.4    Nagar, G.K.5    Romero, J.R.6
  • 47
    • 83555166212 scopus 로고    scopus 로고
    • Achyranthes bidentata root extract prevent OVX-induced osteoporosis in rats
    • Zhang R., Hu S.J., Li C., Zhang F., Gan H.Q., Mei Q.B. Achyranthes bidentata root extract prevent OVX-induced osteoporosis in rats. J Ethnopharmacol 2012, 139:12-18.
    • (2012) J Ethnopharmacol , vol.139 , pp. 12-18
    • Zhang, R.1    Hu, S.J.2    Li, C.3    Zhang, F.4    Gan, H.Q.5    Mei, Q.B.6
  • 48
    • 67949120224 scopus 로고    scopus 로고
    • Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats
    • Zhang R., Liu Z.G., Li C., Hu S.J., Liu L., Wang J.P., et al. Du-Zhong (Eucommia ulmoides Oliv.) cortex extract prevent OVX-induced osteoporosis in rats. Bone 2009, 45:553-559.
    • (2009) Bone , vol.45 , pp. 553-559
    • Zhang, R.1    Liu, Z.G.2    Li, C.3    Hu, S.J.4    Liu, L.5    Wang, J.P.6
  • 49
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmenopausal bone loss
    • Kalu D.N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner 1991, 15:175-191.
    • (1991) Bone Miner , vol.15 , pp. 175-191
    • Kalu, D.N.1
  • 50
    • 22744432029 scopus 로고    scopus 로고
    • Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro
    • Sliwinski L., Folwarczna J., Janiec W., Grynkiewicz G., Kuzyk K. Differential effects of genistein, estradiol and raloxifene on rat osteoclasts in vitro. Pharmacol Rep 2005, 57:352-359.
    • (2005) Pharmacol Rep , vol.57 , pp. 352-359
    • Sliwinski, L.1    Folwarczna, J.2    Janiec, W.3    Grynkiewicz, G.4    Kuzyk, K.5
  • 51
    • 47349132821 scopus 로고    scopus 로고
    • Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action
    • Poulsen R.C., Kruger M.C. Soy phytoestrogens: impact on postmenopausal bone loss and mechanisms of action. Nutr Rev 2008, 66:359-374.
    • (2008) Nutr Rev , vol.66 , pp. 359-374
    • Poulsen, R.C.1    Kruger, M.C.2
  • 52
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas S.C., Jilka R.L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995, 332:305-311.
    • (1995) N Engl J Med , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 53
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3    Yamaguchi, A.4    Sasaki, K.5    Deguchi, K.6
  • 54
    • 2942548981 scopus 로고    scopus 로고
    • Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
    • Stein G.S., Lian J.B., van Wijnen A.J., Stein J.L., Montecino M., Javed A., et al. Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 2004, 23:4315-4329.
    • (2004) Oncogene , vol.23 , pp. 4315-4329
    • Stein, G.S.1    Lian, J.B.2    van Wijnen, A.J.3    Stein, J.L.4    Montecino, M.5    Javed, A.6
  • 55
    • 20044363794 scopus 로고    scopus 로고
    • Introduction to systematic reviews of animal studies
    • Xiong W., Wei Q., Liu X.M. Introduction to systematic reviews of animal studies. Chin J Evid Based Med 2005, 5:161-163.
    • (2005) Chin J Evid Based Med , vol.5 , pp. 161-163
    • Xiong, W.1    Wei, Q.2    Liu, X.M.3
  • 57
    • 0038616401 scopus 로고    scopus 로고
    • Emergency medicine animal research: does use of randomization and blinding affect the results?
    • Bebarta V., Luyten D., Heard K. Emergency medicine animal research: does use of randomization and blinding affect the results?. Acad Emerg Med 2003, 10:684-687.
    • (2003) Acad Emerg Med , vol.10 , pp. 684-687
    • Bebarta, V.1    Luyten, D.2    Heard, K.3
  • 60
    • 33845400991 scopus 로고    scopus 로고
    • Epidemiologic evidence suggests that dietary phytoestrogen intake is associated with reduced risk of breast, endometrial, and prostate cancers
    • Lof M., Weiderpass E. Epidemiologic evidence suggests that dietary phytoestrogen intake is associated with reduced risk of breast, endometrial, and prostate cancers. Nutr Res 2006, 26:609-619.
    • (2006) Nutr Res , vol.26 , pp. 609-619
    • Lof, M.1    Weiderpass, E.2
  • 61
    • 84899647756 scopus 로고    scopus 로고
    • Soy and isoflavone intake associated with reduced risk of ovarian cancer in southern Chinese women.
    • Lee AH, Su D, Pasalich M, Tang L, Binns CW, Qiu L. Soy and isoflavone intake associated with reduced risk of ovarian cancer in southern Chinese women. Nutr Res 34, 2014, 304-307.
    • (2014) Nutr Res , vol.34 , pp. 304-307
    • Lee, A.H.1    Su, D.2    Pasalich, M.3    Tang, L.4    Binns, C.W.5    Qiu, L.6
  • 62
    • 84888267104 scopus 로고    scopus 로고
    • Soy and its isoflavones: the truth behind the science in breast cancer
    • Douglas C.C., Johnson S.A., Arjmandi B.H. Soy and its isoflavones: the truth behind the science in breast cancer. Anticancer Agents Med Chem 2013, 13:1178-1187.
    • (2013) Anticancer Agents Med Chem , vol.13 , pp. 1178-1187
    • Douglas, C.C.1    Johnson, S.A.2    Arjmandi, B.H.3
  • 63
    • 84864073889 scopus 로고    scopus 로고
    • Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in overiectomized rats
    • Hassan H.A., Abdel-Wahhab M.A. Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in overiectomized rats. J Physiol Biochem 2012, 68:247-253.
    • (2012) J Physiol Biochem , vol.68 , pp. 247-253
    • Hassan, H.A.1    Abdel-Wahhab, M.A.2
  • 64
    • 84878845528 scopus 로고    scopus 로고
    • Genistein inhibits cell proliferation and stimulates apoptosis in human coronary artery endothelial cells
    • Kayisli U.A., Guzeloglu-Kayisli O., Guzel E., Arici A. Genistein inhibits cell proliferation and stimulates apoptosis in human coronary artery endothelial cells. Gynecol Obstet Invest 2013, 75:235-242.
    • (2013) Gynecol Obstet Invest , vol.75 , pp. 235-242
    • Kayisli, U.A.1    Guzeloglu-Kayisli, O.2    Guzel, E.3    Arici, A.4
  • 65
    • 33646027300 scopus 로고    scopus 로고
    • Soy isoflavones and bone health: a double-edged sword?
    • Reinwald S., Weaver C.M. Soy isoflavones and bone health: a double-edged sword?. J Nat Prod 2006, 69:450-459.
    • (2006) J Nat Prod , vol.69 , pp. 450-459
    • Reinwald, S.1    Weaver, C.M.2
  • 67
    • 84879604364 scopus 로고    scopus 로고
    • Adverse influence of coumestrol on secretory function of bovine luteal cells in the first trimester of pregnancy
    • Mlynarczuk J., Wrobel M.H., Kotwica J. Adverse influence of coumestrol on secretory function of bovine luteal cells in the first trimester of pregnancy. Environ Toxicol 2013, 28:411-418.
    • (2013) Environ Toxicol , vol.28 , pp. 411-418
    • Mlynarczuk, J.1    Wrobel, M.H.2    Kotwica, J.3
  • 68
    • 84886687721 scopus 로고    scopus 로고
    • Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis
    • Sato F., Martinez N.E., Shahid M., Rose J.W., Carlson N.G., Tsunoda I. Resveratrol exacerbates both autoimmune and viral models of multiple sclerosis. Am J Pathol 2013, 183:1390-1396.
    • (2013) Am J Pathol , vol.183 , pp. 1390-1396
    • Sato, F.1    Martinez, N.E.2    Shahid, M.3    Rose, J.W.4    Carlson, N.G.5    Tsunoda, I.6
  • 69
    • 84858954315 scopus 로고    scopus 로고
    • Reproductive consequences of developmental phytoestrogen exposure
    • Jefferson W.N., Patisaul H.B., Williams C.J. Reproductive consequences of developmental phytoestrogen exposure. Reproduction 2012, 143:247-260.
    • (2012) Reproduction , vol.143 , pp. 247-260
    • Jefferson, W.N.1    Patisaul, H.B.2    Williams, C.J.3
  • 70
    • 84887019932 scopus 로고    scopus 로고
    • Phytoestrogens in the prevention of postmenopausal bone loss
    • Lagari V.S., Levis S. Phytoestrogens in the prevention of postmenopausal bone loss. J Clin Densitom 2013, 16:445-449.
    • (2013) J Clin Densitom , vol.16 , pp. 445-449
    • Lagari, V.S.1    Levis, S.2
  • 71
    • 84889883722 scopus 로고    scopus 로고
    • Phytoestrogens for menopausal bone loss and climacteric symptoms
    • Lagari V.S., Levis S. Phytoestrogens for menopausal bone loss and climacteric symptoms. J Steroid Biochem Mol Biol 2014, 139:294-301.
    • (2014) J Steroid Biochem Mol Biol , vol.139 , pp. 294-301
    • Lagari, V.S.1    Levis, S.2
  • 72
    • 80655141715 scopus 로고    scopus 로고
    • Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis
    • Salari Sharif P., Nikfar S., Abdollahi M. Prevention of bone resorption by intake of phytoestrogens in postmenopausal women: a meta-analysis. Age (Dordr) 2011, 33:421-431.
    • (2011) Age (Dordr) , vol.33 , pp. 421-431
    • Salari Sharif, P.1    Nikfar, S.2    Abdollahi, M.3


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