Where is the evidence that animal research benefits humans?

British Medical Journal

Volumn 328, Issue 7438, 2004, Pages 514-517

  Pound, Pandora ^a   Ebrahim, Shah ^a   Sandercock, Peter ^b   Bracken, Michael B ^c   Roberts, Ian ^d  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL RESEARCH; EVIDENCE BASED MEDICINE; EXPERIMENTAL ANIMAL; HUMAN; INFORMATION RETRIEVAL; MEDICAL ASSESSMENT; MEDLINE; NONHUMAN; PRIORITY JOURNAL; PUBLICATION; REVIEW; SYSTEMATIC REVIEW;

EID: 1442311168     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.328.7438.514     Document Type: Review

References (28)

1. Schechter AN, Retting RA. Funding priorities for medical research. JAMA 2002;288:832.
2. Page K. Cambridge primate centre comes under scrutiny. Lancet Neurol 2003;2:136.
3. House of Lords. Report of select committee on animals in scientific procedures, 16 July 2002. London: Stationery Office, 2002:22(para 4.8).
4. Stewart PM. Improving clinical research. BMJ 2003;327:999-1000.
5. Grant J, Green L, Mason B. From bedside to bench: Comroe and Dripps revisited. London: Brunel University, 2003. (HERG (Health Economics Research Group) Research Report No 30).
6. Woodman R. Explanations shift attitudes to animal experiments. BMJ 1999;318:1438.
7. Reines BP. On the locus of medical discovery. J Med Philos 1991;16:183-209.
8. Shapiro KJ. Animal models of human psychology. Seattle: Hogrefe and Huber, 1998.
9. Plous S. Attitudes toward the use of animals in psychological research and education: results from a national survey of psychologists. Am Psychol 1996;51:1167-80.
10. Dagg AI. Responsible animal-based research. J Appl Anim Welfare Sci 1999;2:337-46.
11. Horn J, de Haan RJ, Vermeulen M, Luiten PGM, Limburg M. Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke 2001;32:2433-8.
12. Horn J, Limburg M. Calcium antagonists for ischemic stroke: a systematic review. Stroke 2001;32:570-6.
13. Lucas C, Criens-Poublon LJ, Cockrell CT, de Haan RJ. Wound healing in cell studies and animal model experiments by low level laser therapy; were clinical studies justified? A systematic review. Lasers Med Sci 2002;17:110-34.
14. Roberts I, Kwan I, Evans P, Haig S. Does animal experimentation inform human health care? Observations from a systematic review of international animal experiments on fluid resuscitation. BMJ 2002;324:474-6.
15. Mapstone J, Roberts I, Evans P. Fluid resuscitation strategies: a systematic review of animal trials. J Trauma Injury Infect Crit Care 2003;55:571-89.
16. Roberts I, Evans A, Bunn F, Kwan I, Crowhurst E. Normalising the blood pressure in bleeding trauma patients may be harmful. Lancet 2001;357:385-7.
17. Ciccone A, Candelise L. Risk of cerebral haemorrhage after thrombolysis: systematic review of animal stroke models. In: Proceedings of the European Stroke Conference, Valencia, May 2003.
18. Petticrew M, Davey Smith G. Monkey business: what do primate studies of social hierarchies, stress, and the development of CHD tell us about humans? J Epidemiol Community Health 2003;57(suppl 1):A1-21.
19. Brunner E. Towards a new social biology. In: Berkman L, Kawachi I, eds. Social epidemiology. Oxford: Oxford University Press, 2000:306-31.
20. Lee DS, Nguyen QT, Lapointe N, Austin PC, Ohlsson A, Tu JV, et al. Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failure. J Cardiac Fail 2003;9:368-74.
21. Bebarta B, Luyten D, Heard K. Emergency medicine animal research: does use of randomization and blinding affect the results? Acad Emerg Med 2003;10:684-7.
22. Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med 1992;327:248-54.
23. Medical Research Council. Clinical trials outline form www.mrc.ac.uk/doc-mrc_clinic.doc (accessed 20 Jan 2003).
24. Smith R. Animal research: the need for a middle ground. BMJ 2001;322:248-9.
25. Comroe JH, Dripps RD. Scientific basis for the support of biomedical science. Science 1976;192:105-11.
26. Smith R. Comroe and Dripps revisited. BMJ 1987;295:1404-7.
27. Cochrane Collaboration. www.cochrane.org (accessed 20 Jan 2003).
28. Campbell Collaboration. www.campbellcollaboration.org (accessed 20 Jan 2003).