Alginate-based drug delivery devices

Biointegration of Medical Implant Materials: Science and Design

Volumn , Issue , 2010, Pages 236-266

  Grondahl L ^a   Lawrie, G ^a   Jejurikar, A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alginate; Drug delivery; Encapsulation; Hydrogel; Ionic and covalent crosslinking

Indexed keywords

BIOCOMPATIBILITY; CROSSLINKING; DRUG DELIVERY; ENCAPSULATION; HYDROGELS;

ACTIVE BIOMOLECULES; COVALENT CROSSLINKING; DRUG DELIVERY DEVICES; DRUG DELIVERY SYSTEM; RELEASE PROFILES; STRUCTURAL FUNCTIONALITY;

ALGINATE;

EID: 84904087268     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1533/9781845699802.2.236     Document Type: Chapter

References (124)

1. Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W.G., Zhao F., Li Z.Y., Leong J.C.Y., Luk K.D.K. Osteogenic behaviour of alginate encapsulated bone marrow stromal cells: an in vitro study. Journal of Materials Science Materials in Medicine 2008, 19:2113-2119.
2. Al Musa S., Abu Fara D., Badwan A.A. Evaluation of parameters involved in preparation and release of drug loaded in crosslinked matrices of alginate. Journal of Controlled Release 1999, 57:223-232.
3. Al-Shamkhani A., Duncan R. Synthesis, controlled-release properties antitumor activity of alginate-cis-aconityl-daunomycin conjugates. International Journal of Pharmaceutics 1995, 122(1-2):107-119.
4. Anal A.K., Stevens W.F. Chitosan-alginate multilayer beads for controlled release of ampicillin. International Journal of Pharmaceutics 2005, 290:45-54.
5. Aslani P., Kennedy R.A. Studies on diffusion in alginate gels. I. Effect of crosslinking with calcium or zinc ions on diffusion of acetaminophen. Journal of Controlled Release 1996, 42:75-82.
6. Augst A.D., Kong H.J., Mooney D.J. Alginate hydrogels as biomaterials. Macromolecular Bioscience 2006, 6:623-633.
7. Balakrishnan B., Jayakrishnan A. Self-crosslinking biopolymers as injectable in situ forming biodegradable scaffolds. Biomaterials 2005, 26:3941-3951.
8. Balakrishnan B., Lesieur S., Labarre D., Jayakrishnan A. Periodate oxidation of sodium alginate in water and in ethanol-water mixture: A comparative study. Carbohydrate Research 2005, 340:1425-1429.
9. Bernkop-Schnürch A., Greimel A. Thiomers; the next generation of mucoadhesive polymers. American Journal of Drug Delivery 2005, 3(3):141-154.
10. Bouhadir K.H., Lee K.Y., Alsberg E., Damm K.L., Anderson K.W., Mooney D.J. Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnology Progress 2001, 17:945-950.
11. 2+ induced gelation in alginates and pectins: The egg-box model revisited. Biomacromolecules 2001, 2:1089-1096.
12. Bünger C.M., Gerlach C., Freier T., Schmitz K.P., Pilz M., Werner C., Jonas L., Scharek W., Hopt U.T., De Vos P. Biocompatability and surface structure of chemically modified immunoisolating alginate-PLL capsules. Journal of Biomedical and Materials Research 2003, 67A:1219-1227.
13. Chan A.W., Whitney R.A., Neufeld R.J. Kinetic controlled synthesis of pH- responsive network alginate. Biomacromolecules 2008, 9(9):2536-2545.
14. Chan L.W., Jin Y., Heng P.W.S. Crosslinking mechanisms of calcium and zinc in production of alginate microspheres. International Journal of Pharmaceutics 2002, 242(1-2):255-258.
15. Coleman R. Phosphorylation of alginate and its potential as a biomaterial 2007, The University of Queensland, Australia, Honors thesis.
16. Connelly J.T., Garcia A.J., Levenston M.E. Inhibition of in vitro chondrogenesis in RGD-modified three dimensional alginate gels. Biomaterials 2007, 28:1071-1083.
17. Corkhill P.H., Trevett A.S., Tighe B.J. 'The potential of hydrogels as synthetic articular cartilage' Proceedings of the Institution of Mechanical Engineers. Part H: Journal of Engineering in Medicine 1990, 204(H3):147-155.
18. 2+ crosslinked alginate beads affects proliferation and insulin secretion. Journal of Microencapsulation 2006, 23:663-676.
19. De Boisseson M.R., Leonard M., Hubert P., Marchal P., Stequert A., Castel C., Favre E., Dellacherie E. Physical alginate hydrogels based on hydrophobic or dual hydrophobic/ionic interactions: Bead formation, structure, and stability. Journal of Colloid and Interface Science 2004, 273:131-139.
20. De Guzman R.C., Ereifej E.S., Broadrick K.M., Rogers R.A., Vandevord P.J. Alginate-matrigel microencapsulated Schwann cells for inducible secretion of glial cell line derived neurotrophic factor. Journal of Microencapsulation 2008, 25:487-498.
21. Desai S.J., Simonelli A.P., Higuchi W.L. Investigation of factors influencing release of solid drug dispersed in inert matrices. Journal of Pharmaceutical Sciences 1965, 54:1459-1463.
22. De Vos P., De Haan B.J., Wolters G.H.J., Van Schilfgaarde R. Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets. Diabetologia 1997, 40:262-270.
23. De Vos P., Faas M.M., Strand B., Calafiore R. Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials 2006, 27:5603-5617.
24. Dhoot N.O., Tobias C.A., Fischer I., Wheatley M.A. Peptide-modified alginate surfaces as a growth permissive substrate for neurite outgrowth. Journal of Biomedical Materials Research 2004, 71A:191-200.
25. Donati I., Holtan S., Borgogna M., Dentini M., Skjåk-Braek G. New Hypothesis on the Role of Alternating Sequences in Calcium-Alginate Gels. Biomacromolecules 2005, 6(2):1031-1040.
26. Drury J.L., Boontheekul T., Mooney D.J. Cellular crosslinking of peptide modified hydrogels. Journal of Biomechanical Engineering 2005, 127:220-228.
27. Drury J.L., Dennis R.G., Mooney D.J. Tensile properties of alginate hydrogels. Biomaterials 2004, 25(16):3187-3199.
28. Dusseault J., Langlois G., Meunier M.-C., Ménard M., Perreault C., Hallé J.-P. The effect of covalent cross-links between the membrane components of microcapsules on the dissemination of encapsulated malignant cells. Biomaterials 2008, 29:917-924.
29. Eiselt P., Rowley J.A., Mooney D.J. PEG crosslinked alginate hydrogels with controlled mechanical properties. Materials Research Society Symposium Proceedings 1998, 530:37-42.
30. Eiselt P., Lee K.Y., Mooney D.J. Rigidity of two-component hydrogels prepared from alginate and poly(ethylene glycol)-diamines. Macromolecules 1999, 32:5561-5566.
31. Ertersvag H., Doest B., Larsen B., Skjåk-Braek G., Valla S. Cloning and expression of an Azobacter vinelandii manuunronan C-5 epimerase gene. Journal of Bacteriology 1994, 176:2846-2853.
32. Evangelista M.B., Hsiong S.X., Fernandes R., Sampiato P., Kong H.J., Barrias C., Salema R., Barbosa M.A., Mooney D.J., Granja P.L. Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials 2007, 28:3644-3655.
33. Folkman J., Long D.M. The use of silicone rubber as a carrier for prolonged drug delivery. Journal of Surgical Research 1964, 4:139-142.
34. Fundueanu G., Nastruzzi C., Carpov A., Desbriesres J., Rinaudo M. Physicochemical characterization of Ca-alginate microparticles produced with different methods. Biomaterials 1999, 20(15):1427-1435.
35. Gacesa P. Enzymic degradation of alginates. International Journal of Biochemistry 1992, 24(4):545-552.
36. Gomez C., Rinaudo M., Villar M.A. Oxidation of sodium alginate and characterization of the oxidized derivatives. Carbohydrate Polymers 2007, 67:296-304.
37. Grandoso L., Ponce S., Manuel I., Arrúe A., Ruiz-Ortega J.A., Ulibarri I., Orive G., Hernández R.M., Rodríguez A., Rodríguez-Puertas R., Zumárraga M., Linazasoro G., Pedra L., Ugedo L. Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of Parkinsonized rats. International Journal of Pharmaceutics 2007, 343:69-78.
38. Grant G.T., Morris E.R., Rees D.A., Smith P.J.C., Thom D. Biological interactions between polysaccharides and divalent cations: The egg-box model. FEBS Letters 1973, 32(1):195-198.
39. Greimel A., Werle M., Bernkop-Schnürch A. Oral peptide delivery: In-vitro evaluation of thiolated alginate/poly(acrylic acid) microparticles. Journal of Pharmacy and Pharmacology 2007, 59:1191-1198.
40. Grøndahl L., Jack K. Composite materials for bone repair' in Biomedical Composites 2009, Chapter 5, Woodhead Publishing Limited, UK, ISBN: 1 84569 4368. L. Ambrosio (Ed.).
41. Hermes R.H., Narayani R. Polymeric alginate films and alginate beads for the controlled delivery of macromolecules. Trends in Biomaterials and Artificial Organs 2002, 15:54-56.
42. Hill E., Boontheekul T., Mooney D.J. Designing scaffolds to enhance transplanted myoblast survival and migration. Tissue Engineering 2006, 12:1295-1304.
43. Holme H.K., Lindmo K., Kristiansen A., Smidsrød O. Thermal depolymerisation of alginate in the solid state. Carbohydrate Polymers 2003, 54:431-438.
44. Hosoya K., Ohtsuki C., Kawai T., Kamitakahara M., Ogata S., Miyazaki T., Tanihara M. A novel covalently crosslinked gel of alginate and silane with the ability to form bone-like apatite. Journal of Biomedical Materials Research 2004, 71A:596-601.
45. Jejurikar A., Lawrie G., Martin D., Grøndahl L. Improved alginate based hydrogels for articular cartilage replacement 2008, Amsterdam.
46. Jejurikar A., Lawrie G., Martin D., Jayakrishnan A., Grøndahl L. Potential role of novel alginate hydrogel based biomaterials for articular cartilage repair 2009, Sydney.
47. Jørgensen T.E., Sletmoen M., Draget K.I., Stokke B.T. Influence of oligoguluronates on alginate gelation, kinetics, and polymer organization. Biomacromolecules 2007, 8(8):2388-2397.
48. Kim H.W., Han C.D. An overview of cartilage tissue engineering. Yonsei Medical Journal 2000, 41(6):766-773.
49. Kim Y.J., Yoon K.J., Ko S.W. Preparation and properties of alginate superabsorbent filament fibres crosslinked with gluteraldehyde. Journal of Applied Polymer Science 2000, 78:1797-1804.
50. Klock G., Frank H., Houben R., Zekorn T., Horcher A., Seibers U., Wohrle M., Federlin K., Zimmermann U. Production of purified alginates suitable for use in immunoisolated transplantation. Applied Microbiology Biotechnology 1994, 40(5):638-643.
51. Krylova E., Ivanoc A., Orlovski V., El-Registan G., Barivon S. Hydroxyapatite-polysaccharide granules for drug delivery. Journal of Materials Science and Materials Medicine 2002, 13:87-90.
52. Kuo C.K., Ma P.X. Maintaining dimensions and mechanical properties of ionically crosslinked alginate hydrogel scaffolds in vitro. Journal of Biomedical Materials Research 2008, 84:899-907.
53. Lacik I. Polymer chemistry in diabetes treatment by encapsulated islets of Langerhans: Review to 2006. Australian Journal of Chemistry 2006, 59:508-524.
54. Lee K.Y., Bouhadir K.H., Mooney D.J. Degradation behavior of covalently crosslinked poly(aldehyde guluronate) hydrogels. Macromolecules 2000, 33:97-101.
55. Lee K.H., Bouhadir K.H., Mooney D.J. Controlled degradation of hydrogels using multi-functional cross-linking molecules. Biomaterials 2004, 25:2461-2466.
56. Lee K.H., Rowley J.A., Eiselt P., Moy E.M., Bouhadir K.H., Mooney D.J. Controlling mechanical and swelling properties of alginate hydrogels independently by crosslinker type and crosslinking density. Macromolecules 2000, 33:4291-4294.
57. Lee M., Lo A.C., Cheung P.T., Wong D., Chan B.P. Drug carrier systems based on collagen-alginate composite structures for improving the performance of GDNF-secreting HEK293 cells. Biomaterials 2009, 30:1214-1221.
58. Leonard M., De Boisseson M.R., Hubert P., Dalençon F., Dellacherie E. Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties. Journal of Controlled Release 2004, 98:395-405.
59. Le Roux M.A., Guilak F., Setton L.A. Compressive and shear properties of alginate gel: Effects of sodium ions and alginate concentration. Journal of Biomedical Materials Research 1999, 47(1):46-53.
60. Leung A., Lawrie G.A., Nielsen L.K., Trau M. Synthesis and characterization of alginate/poly-L-ornithine/alginate microcapsules for local immunosuppression. Journal of Microencapsulation 2008, 25:387-398.
61. Li A.A., Bourgois J., Potter M., Chang P.L. Isolation of human foetal myoblasts and its application for microencapsulation. Journal of Cell Molecular Medicine 2008, 12:271-280.
62. Li L., Fang Y., Vreeker R., Mendes I. Re-examining the egg-box model in Calcium-Alginate gels by X-Ray Diffraction. Biomacromolecules 2007, 8(2):464-468.
63. Lim F., Sun A.M. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980, 210:908-910.
64. Lin H.R., Yeh Y.J. Porous alginate/hydroxyapatite composite scaffolds for bone tissue engineering: Preparation, characterization and in vitro studies. Journal of Biomedical Materials Research Part B: Applied Biomaterials 2004, 71(1):52-65.
65. Lin J., Yu W., Liu X., Xie H., Wang W., Ma X. In vitro and in vivo characterization of alginate-chitosan-alginate artificial microcapsules for therapeutic oral delivery of live bacterial cells. Journal of Bioscience and Bioengineering 2008, 6:660-665.
66. Luca G., Calvitti M., Nastruzzi C., Bilancetti L., Becchetti E., Angeletti G., Mancuso F., Calafiore R. Encapsulation, in vitro characterization, and in vivo biocompatibility of sertoli cells in alginate-based microcapsules. Tissue Engineering 2007, 13:641-648.
67. Malaprade L. Action of polyalcohols on periodic acids. Analytical application. Bulletin de la Societe Chimique de France 1928, 43:683-696.
68. Marsich E., Borgogna M., Donat I., Mozetic P., Strand B.L., Gomez Salvador S., Vittur F., Paoletti S. Alginate/lactose-modified chitosan hydrogels: A bioactive material for chrondrocyte encapsulation. Jounal of Biomedical Materials Research 2008, 84A:364-376.
69. Matricardi P., Pontoriero M., Coviello T., Casadei M.A., Alhaique F. In situ crosslinkable novel alginate-dextran methacrylate IPN hydrogels for biomedical applications: Mechanical characterization and drug delivery properties. Biomacromolecules 2008, 9(7):2014-2020.
70. Matsusaki M., Sakaguchi H., Serizawa T., Akashi M. Controlled release of vascular endothelial growth factor from alginate hydrogels nano-coated with polyelectrolyte multilayer films. Journal of Biomaterials Science Polymer Edition 2007, 18(6):775-783.
71. Maruyama M. Hydroxyapatite clay used to fill the gap between implants and bone. Journal of Bone and Joint Surgery (Br) 1995, 77(2):213-218.
72. Moe S.T., Skjåk-Braek G., Elgsaeter A., Smidsrød O. Swelling of covalently crosslinked alginate gels: Influence of ionic solutes and non-polar solvents. Macromolecules 1993, 26:3589-3597.
73. Mørch Y.A., Donati I., Strand B.L., Skjåk-Braek G. Effect of Ca, Ba, Sr on alginate microbeads. Biomacromolecules 2006, 7:1471-1480.
74. Mørch Y.A., Donati I., Strand B.L., Skjåk-Braek G. Molecular engineering as an approach to design new functional properties of alginate. Biomacromolecules 2007, 8:2809-2814.
75. Mørch Y.A., Holtan S., Donati I., Strand B.L., Skjåk-BraeK G. Mechanical properties of C-5 epimerized alginates. Biomacromolecules 2008, 9(9):2360-2368.
76. Mucalo M.R., Yokogawa Y., Suzuki T., Kawamoto Y., Nagata F., Nishizawa K. Further studies of calcium phosphate growth on phosphorylated cotton fibres. Journal of Materials Science Materials Medicine 1995, 6(11):658-669.
77. Narang A.S., Mahato R.I. Biological and biomaterial approaches for improved islet transplantation. Pharmacological Reviews 2006, 58:194-243.
78. Nguyen V.B., Wang C.X., Thomas C.R., Zhang Z. Mechanical properties of single alginate microspheres determined by microcompression and finite element modelling. Chemical Engineering Science 2009, 64(5):821-829.
79. Nunamaker E.A., Purcell E.K., Kipke D.R. In vivo stability and biocompatibility of implanted calcium alginate disks. Journal of Biomedical Materials Research 2007, 83A:1128-1137.
80. Omer A., Duvivier-Kali V., Fernandes J., Tchipashvili V., Colton C.K., Weir G.C. Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation 2005, 79:52-58.
81. Orive G., De Castro M., Ponce S., Hernandez R.M., Gascon A.R., Boch M., Alberch J., Pedraz J.L. Long-term expression of erythropoietin from myoblasts immobilized in biocompatible and neovascularised microcapsules. Molecular Therapy 2005, 12:283-289.
82. Paul W., Sharma C.P. Infection resistant hydroxyapatite/alginate plastic composite. Journal of Materials Science Letters 1997, 16:2050-2051.
83. Pavlath A.E., Gossett C., Camirad W., Robertson G.H. Ionomeric films of alginic acid. Journal of Food Science 1999, 64(1):61-63.
84. Pelletier A., Hubert P., Lapicque F., Payan E., Dellacherie E. Amphillic derivatives of sodium alginate and hyaluronate: Synthesis and physicochemical properties of aqueous dilute solutions. Carbohydrate Polymers 2000, 43:343-349.
85. Ponce S., Orive G., Hernández R.M., Gascón A.R., Canals J.M., Muñoz M.T., Pedraz J.L. In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules. Journal of Controlled Release 2006, 116:28-34.
86. Poncelet D., Lencki R., Beaulieu C., Halle J.P., Neufeld R.J., Fournier A. Production of alginate beads by emulsification/internal gelation. I. Methodology. Applied Microbiology and Biotechnology 1992, 38(1):39-45.
87. Qin Y. The gel swelling properties of alginate fibers and their applications in wound management. Polymers for Advanced Technologies 2008, 19(1):6-14.
88. Ranade V.V., Hollinger M.A. Drug Delivery Systems 2004, Florida, CRC Press Inc., Boca Raton, 63-114. 2nd Edition.
89. Ribeiro C.C., Barrias C.C., Barbosa M.A. Calcium phosphate-alginate microspheres as enzyme delivery matrices. Biomaterials 2004, 25:4363-4373.
90. Remuñán-López C., Bodmeier R. Mechanical, water uptake and permeability properties of crosslinked chitosan glutamate and alginate films. Journal of Controlled Release 1997, 44:215-225.
91. Rowley J.A., Madlambayan G., Mooney D.J. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1999, 20:45-53.
92. Sakai S., Kawakami K. Both ionically and enzymatically crosslinkable alginate-tyramine conjugate as materials for cell encapsulation. Journal of Biomedical Materials Research 2008, 85A:345-351.
93. Salomonsen T., Jensen H.M., Steinbæk D., Engelsen S.B. Chemometric prediction of alginate monomer composition: A comparative spectroscopic study using IR, Raman, NIR and NMR. Carbohydrate Polymers 2008, 72:730-739.
94. Shishu, Gupta N., Aggarwal N. Stomach-specific drug delivery of 5-fluoracil using floating alginate beads. AAPS PharmSciTech 2007, 8:E1-E7.
95. Shoichet M.S., Li R.H., White M.L., Winn S.R. Stability of hydrogels used in cell encapsulation: An in vitro comparison of alginate and agarose. Biotechnology and Bioengineering 1995, 50:374-381.
96. Sikorski P., Mo F., Skåk-Bræk G., Stokke B.T. Evidence for egg-box-compatible interactions in calcium-alginate gels from fiber x-ray diffraction. Biomacromolecules 2007, 8(7):2098-2103.
97. Sivakumar M., Rao K.P. Infection resistant hydroxyapatite/alginate plastic composite. Journal of Biomedical Materials Research 2003, 64A(2):222-228.
98. Skaugrud Ø., Hagen A., Borgensen B.M., Dornish M. Biomedical and pharmaceutical applications of alginate and chitosan. Biotechnology and Genetic Engineering Reviews 1999, 16(2):23-40.
99. Smeds K.A., Grinstaff M.W. Photocrosslinkable polysaccharides for in situ hydrogel formation. Journal of Biomedical Materials Research 2001, 54:115-124.
100. Smidsrød O., Painter T. Effect of periodate oxidation upon the stiffness of the alginate molecule in solution. Carbohydrate Research 1973, 26:125-132.
101. Smidsrød O., Skjåk-Bræk G. Alginates as immobilization matrix for cells. TIBTECH 1990, 8:71-78.
102. Soon-Shiong P., Otterlie M., Skjak-Braek G., Smidsrod O., Heintz R., Lanza R.P., Espevik T. 'An immunologic basis for the fibrotic reaction to implanted microcapsules. Transplant Proceedings 1991, 23(1Pt1):758-759.
103. Svanem B.I.G., Skjak-Bræk G., Ertesvag H., Valla S. Cloning and expression of three new Azobacter vinelandii genes closely related to a previously described gene family encoding mannuronan C-5 epimerases. Journal of Bacteriology 1999, 181:68-77.
104. Tam Sk, Dusseault J., Polizu S., Ménard M., Hallé J.-P., Yahia L. Physicochemical model of alginate-poly-L-lysine microcapsules defined at the micrometric/nanometric scale using ATR-FTIR, XPS, and ToF-SIMS. Biomaterials 2005, 26:6950-6961.
105. Tan W.-H., Takeuchi S. Monodisperse alginate hydrogel microbeads for cell encapsulation. Advanced Materials 2007, 19:2696-2701.
106. Tan C.S., Jejurikar A., Rai B., Bostrum T., Lawrie G., Grøndahl L. Encapsulation of a glucose amino glycan in hydroxyapatite/alginate capsules. Journal of Biomaterials Research Part A 2009, 91(3):866-877.
107. Taqieddin E., Amiji M. Enzyme immobilization in novel alginate-chitosan core-shell microcapsules. Biomaterials 2004, 25:1937-1945.
108. Turco G., Marsich E., Bellomo F., Semeraro S., Donate I., Brun F., Grandolfo M., Accardo A., Paoletti S. Alginate/hydroxyapatite biocomposite for bone ingrowth: A trabecular structure with high and isotropic connectivity. Biomacromolecules 2009, 10:1575-1583.
109. Vallée F., Müller C., Durand A., Schimchowitsch S., Dellacherie E., Kelche C., Cassel J.C., Leonard M. Synthesis and rheological properties of hydrogels based on amphiphilic alginate-amide derivatives. Carbohydrate Research 2009, 344:223-228.
110. Vold I.M.N., Kristiansen K.A., Christensen B.E. A study of the chain stiffness and extension of alginates, in vitro epimerized alginates, and periodate-oxidized alginates using size exclusion chromatography combined with light scattering and viscosity detectors. Biomacromolecules 2006, 7(7):2136-2146.
111. Wan A.C.A., Yim E.K.F., Liao I.-C., Le Visage C., Leong K. Encapsulation of biologics in self-assembled fibres as biostructured units for tissue engineering. Journal of Biomedical Materials Research 2004, 71A:586-595.
112. Webber R.E., Schull K.R. Strain dependence of the viscoelastic properties of alginate hydrogels. Macromolecules 2004, 37(16):6153-6160.
113. West E.R., Xu M., Woodruff T.K., Shea L.D. Physical properties of alginate hydrogels and their effects on in vitro follicle development. Biomaterials 2007, 28:4439-4448.
114. Whistler R.L., Wolfrom M.L. Methods in Carbohydrate Chemistry 1962, Vol I: Analysis and Preparation of Sugars. Academic Press Inc, New York and London. 2nd edition.
115. Wikström J., Elomaa M., Syväjärvi H., Kuokkannen J., Yliperttula M., Honkakoski P., Urtti A. Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy. Biomaterials 2008, 29:869-876.
116. Wilson J.T., Chaikof E.L. Challenges and emerging technologies in the immunoisolation of cells and tissues. Advanced Drug Delivery Reviews 2008, 60:124-145.
117. Xu J.B., Bartley J.P., Johnson R.A. Preparation and characterization of alginate hydrogel membranes crosslinked using a water-soluble carbodiimide. Journal of Applied Polymer Science 2003, 90:747-753.
118. Xu J.B., Bartley J.P., Johnson R.A. Preparation and characterization of alginate-carrageenan hydrogel films crosslinked using a water-soluble carbodiimide (WSC). Journal of Membrane Science 2003, 218:131-146.
119. Yeom C.K., Lee K.H. Characterization of sodium alginate membrane crosslinked with gluteraldehyde in pervaporation separation. Journal of Applied Polymer Science 1998, 67:209-219.
120. Zhang Y., Wang W., Xie Y., Yu W., Lv G., Guo X., Xiong Y., Ma X. Optimization of microencapsulated recombinant CHO cell growth, endostatin production and stability of microcapsule in vivo. Journal of Biomedical Materials Research B: Applied Biomaterials 2007, 84B:79-88.
121. Zhang W.-J., Li B.-G., Zhang C., Xie X.-H., Tang T.T. Biocompatability and membrane strength of C3H10T1/2 cell-loaded alginate-based microcapsules. Cytotherapy 2008, 10:90-97.
122. Zhu H., Ji J., Lin R., Gao C., Feng L., Shen J. Surface engineering of poly(DL-lactic acid) by entrapment of alginate-amino acid derivatives for promotion of chondrogenesis. Biomaterials 2002, 23:3141-3148.
123. Zimmermann U., Klock G., Federlin K., Hannig K., Kowalski M., Bretzel R.G., Horcher A., Entenmann H., Sieber U., Zekorn T. Production of mitogen-contamination free alginates with variable ratios of mannuronic acid to guluronic acid by free flow electrophoresis. Electrophoresis 1992, 13(5):269-274.
124. Zimmermann H., Zimmermann D., Reuss R., Feilen P.J., Manz B., Katsen A., Weber M., Ihmig F.R., Ehrhart F., Gebner P., Behringer M., Steinbach A., Wegner L.H., Sukhorukov V.L., Vasquez J.A., Schneider S., Weber M.M., Vole F., Wolf R., Zimmermann U. Towards a medically approved technology for alginate-based microcapsules allowing for long-term immunoisolated transplantation. Journal of Materials Science Materials in Medicine 2005, 16:491-501.