Maintaining dimensions and mechanical properties of ionically crosslinked alginate hydrogel scaffolds in vitro

Journal of Biomedical Materials Research - Part A

Volumn 84, Issue 4, 2008, Pages 899-907

  Kuo, Catherine K ^a   Ma, Peter X ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Alginate gel; Mechanical property; Scaffold; Swelling; Tissue engineering

Indexed keywords

CROSSLINKING; GELATION; HYDROGELS; MECHANICAL PROPERTIES; SWELLING; TISSUE ENGINEERING;

ALGINATE GELS; CALCIUM IONS; GELATION REACTION; HYDROGEL SCAFFOLDS;

SCAFFOLDS;

ALGINIC ACID; CALCIUM ALGINATE; CALCIUM ION;

ARTICLE; CHEMICAL COMPOSITION; CROSS LINKING; HYDROGEL; IN VITRO STUDY;

ALGINATES; BIOCOMPATIBLE MATERIALS; CALCIUM; CROSS-LINKING REAGENTS; CULTURE MEDIA; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEL; HYDROGELS; IONS; MODELS, CHEMICAL; MOLECULAR WEIGHT; POLYMERS; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 39749143825     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31375     Document Type: Article

References (37)

1. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002;54:3-12.
2. Ma PX. Scaffolds for tissue fabrication. Mater Today 2004;7:30-40.
3. Ma PX. Tissue engineering. In: Kroschwitz JI, editor. Encyclopedia of Polymer Science and Technology. Hoboken, NJ: Wiley; 2005. p 261-291. www.mrw.interscience.wiley.com/epst.
4. Nguyen KT, West JL. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 2002;23:4307-4314.
5. Elisseeff J. Injectable cartilage tissue engineering. Expert Opin Biol Ther 2004;4:1849-1859.
6. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 2000;50:27-46.
7. Kuo CK, Ma PX. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering. I. Structure, gelation rate and mechanical properties. Biomaterials 2001;22:511-521.
8. Nuttelman CR, Henry SM, Anseth KS. Synthesis and characterization of photocrosslinkable, degradable poly(vinyl alcohol-based tissue engineering scaffolds. Biomaterials 2002;23:3617-3626.
9. Li Q, Wang J, Shahani S, Sun DD, Sharma B, Elisseeff JH, Leong KW. Biodegradable and photocrosslinkable polyphosphoester hydrogel. Biomaterials 2006;27:1027-1034.
10. Li Q, Williams CG, Sun DD, Wang J, Leong K, Elisseeff JH. Photocrosslinkable polysaccharides based on chondroitin sulfate. J Biomed Mater Res A 2004;68:28-33.
11. Burdick JA, Chung C, Jia X, Randolph MA, Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules 2005;6:386-391.
12. Temenoff JS, Athanasiou KA, LeBaron RG, Mikos AG. Effect of poly(ethylene glycol) molecular weight on tensile and swelling properties of oligo(poly(ethylene glycol) fumarate) hydrogels for cartilage tissue engineering. J Biomed Mater Res 2002;59:429-437.
13. Bryant SJ, Anseth KS, Lee DA, Bader DL. Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res 2004;22:1143-1149.
14. Bryant SJ, Anseth KS. Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res 2002;59:63-72.
15. Bryant SJ, Durand KL, Anseth KS. Manipulations in hydrogel chemistry control photoencapsulated chondrocyte behavior and their extracellular matrix production. J Biomed Mater Res A 2003;67:1430-1436.
16. Ma PX. Alginate for tissue engineering. In: Ma PX, Elisseeff J, editors. Scaffolding in Tissue Engineering. Boca Raton, FL: CRC Press; 2005. p 13-25.
17. Draget KI, Ostgaard K, Smidsrod O. Homogeneous alginate gels: A technical approach. Carbohydr Polym 1991;14:159-178.
18. Martinsen A, Skjåk-Bræk G, Smidsrød O. Alginate as immobilization material. I. Correlation between chemical and physical properties of alginate gel beads. Biotechnol Bioeng 1989;33:79-89.
19. Grant GT, Morris ER, Rees DA, Smith PJC, Thom D. Biological interactions between polysaccharides and divalent cations - Egg-Box model. Febs Lett 1973;32:195-198.
20. Rees DA. Polysaccharide shapes and their interactions - Some recent advances. Pure Appl Chem 1981;53:1-14.
21. Skjakbraek G, Smidsrod O, Larsen B. Tailoring of alginates by enzymatic modification invitro. Int J Biol Macromol 1986;8:330-336.
22. Aebischer P, Buchser E, Joseph J, Favre J, de TN, Lysaght M, Rudnick S, Goddard M. Transplantation in humans of encapsulated xenogeneic cells without immunosuppression: A preliminary report. Transplantation 1994;58:1275-1277.
23. Atala A, Kim W, Paige K, Vacanti C, Retik A. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension. J Urol 1994;152(2, Part 2):641-643; discussion 644.
24. Skjåk-Bræk G, Grasdalen H, Smidsrød O. Inhomogeneous polysaccharide ionic gels. Carbohydr Polym 1989;10:31-54.
25. LeRoux MA, Guilak F, Setton LA. Compressive and shear properties of alginate gel: Effects of sodium ions and alginate concentration. J Biomed Mater Res 1999;47:46-53.
26. Williams GM, Klein TJ, Sah RL. Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. Acta Biomater 2005;1:625-633.
27. Elkayam T, Amitay-Shaprut S, Dvir-Ginzberg M, Harel T, Cohen S. Enhancing the drug metabolism activities of C3A-A human hepatocyte cell line-by tissue engineering within alginate scaffolds. Tissue Eng 2006;12:1357-1368.
28. Hill E, Boontheekul T, Mooney DJ. Designing scaffolds to enhance transplanted myoblast survival and migration. Tissue Eng 2006;12:1295-1304.
29. Cohen DL, Malone E, Lipson H, Bonassar LJ. Direct freeform fabrication of seeded hydrogels in arbitrary geometries. Tissue Eng 2006;12:1325-1335.
30. Moe ST, Skjakbraek G, Elgsaeter A, Smidsrod O. Swelling of covalently cross-linked alginate gels - Influence of ionic solutes and nonpolar-solvents. Macromolecules 1993;26:3589-3597.
31. Wang XW, Spencer HG. Calcium alginate gels: Formation and stability in the presence of an inert electrolyte. Polymer 1998;39:2759-2764.
32. Saitoh S, Araki Y, Kon R, Katsura H, Taira M. Swelling/deswelling mechanism of calcium alginate gel in aqueous solutions. Dent Mater J 2000;19:396-404.
33. Thu B, Bruheim P, Espevik T, Smidsrod O, SoonShiong P, SkjakBraek G. Alginate polycation microcapsules. I. Interaction between alginate and polycation. Biomaterials 1996;17:1031-1040.
34. Stokke BT, Draget KI, Smidsrod O, Yuguchi Y, Urakawa H, Kajiwara K. Small-angle X-ray scattering and rheological characterization of alginate gels. I. Ca-alginate gels. Macromolecules 2000;33:1853-1863.
35. Smidsrod O, Skj a-BG. Alginate as immobilization matrix for cells. Trends Biotechnol 1990;8:71-78.
36. Buschmann MD, Gluzband YA, Grodzinsky AJ, Kimura JH, Hunziker EB. Chondrocytes in agarose culture synthesize a mechanically functional extracellular matrix. J Orthop Res 1992;10:745-758.
37. Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res 2000;51:164-171.