Biomedical and Pharmaceutical Applications of Alginate and Chitosan

Biotechnology and Genetic Engineering Reviews

Volumn 16, Issue 1, 1999, Pages 23-40

  Skaugrud, Øyvind ^a   Hagen, Anniken ^a   Borgersen, Berit ^a   Dornish, Michael ^a  

^a Pronova Biomedical   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL APPLICATIONS; PHARMACEUTICAL APPLICATIONS;

CHITOSAN;

ALGINIC ACID; BIOPOLYMER; CHITOSAN; DRUG CARRIER; EXCIPIENT; PROTASAN; UNCLASSIFIED DRUG;

CONTROLLED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; DRUG LEGISLATION; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STRUCTURE; IMMOBILIZED CELL; INTRANASAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; REVIEW; VISCOSITY;

EID: 0032790708     PISSN: 02648725     EISSN: 20465556     Source Type: Journal    
DOI: 10.1080/02648725.1999.10647970     Document Type: Article

References (20)

1. Allan, G. G., Altman, L. C., Bensinger, R. E., Ghosh, D. K., Hirabayashi, Y., Neogi, A. N. and Neogi, S. (1984). Biomedical applications of chitin and chitosan. In Chitin, chitosan and related enzymes. Ed, J. P. Zikakis, pp 119-133. New York: Academic Press.
2. Aspden, T. J., Illum, L. and Skaugrud, Ø. (1997a). Chitosan as a nasal delivery system: evaluation of insulin absorption enhancement and effect on nasal membrane integrity using rat models. European Journal of Pharmaceutical Science 4, 23-31.
3. Aspden, T. J., Mason, J. D. T., Jones, N. S., Lowe, J., Skaugrud, Ø. and Illum, L. (1997b). Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucocilliary transport rates in human turbinates and volunteers. Journal of Pharmaceutical Science 86, 509-513.
4. Dornish, M., Hagen, A., Hansson, E., Pecheur, C., Verdier, F. and Skaugrud, Ø. (1997a). Safety of PROTASAN™: Ultrapure chitosan salts for biomedical and pharmaceutical use. In Advances in Chitin Science, vol. 2. Eds, A. Domard, G. A. F. Roberts and K. M. Vårum, pp 664-670. Lyon: Jacques Andre Publicher.
5. Dornish, M., Skaugrud, Ø., Illum, L. and Davis, S. S. (1997b). Nasal drug delivery with PROTASAN™. In Advances in Chitin Science, vol. 2. Eds, A. Domard, G. A. F. Roberts and K. M. Vårum, pp 694-697. Lyon: Jacques Andre Publicher.
6. Grasdalen, H. (1983). High-field 'H-n. m. r. spectroscopy of alginate: sequential structure and linkage conformations. Carbohydrate Research 118, 255-260.
7. Hagen, A., Skjak-Bræk, G. and Dornish, M. (1996), Pharmo kinetics of sodium alginate in mice. European Journal of Pharmaceutical Sciences 4 (suppl.), S100.
8. Hirano, S., Seino, H., Akiyama, Y. and Nonaka, I. (1990). Chitosan: A biocompatible material for oral and intravenous administrations. In Progress in Biomedical Polymers. Eds, C. G. Gebelein and R. L. Dunn, pp 283-290. New York: Plenum Press.
9. Illum, L., Farraj, N. F. and Davis, S. S. (1994). Chitosan as a novel nasal delivery system for peptide drugs. Pharmaceutics Research II, 1186-1189.
10. Li, Q., Dunn, E. T., Grandmaison, E. W. and Goosen, M. F. A. (1992). Applications and properties of chitosan. Journal of Bioactive Compatible Polymers 7, 370-397.
11. Lim, F. and Sun, A. M. (1980). Microencapsulated islets as a bioartificial endocrine pancreas. Science 210, 908-910.
12. No, H. K. and Meyers, S. P. (1995). Preparation and characterization of chitin and chitosan - a review. Journal of Aquatic Food Product Technology 4, 27-52.
13. Skaugrud, Ø. and Sargent, G. (1990). Chitin and chitosan: Crustacean biopolymers with potential. In Making Profits out of Seafood Wastes. Ed, S. Keller, pp 61-69. Alaska: Alaska Sea Grant College Program AK-SG-. 90-07.
14. Skaugrud, Ø. (1995). Drug delivery systems with alginate and chitosan. In Excipients and Delivery Systems for Pharmaceutical Formulations. Eds, D. R. Karsa and R. A. Stephenson, pp 96-107. Cambridge: Spec. Publ. Royal Soc. Chem. No 161.
15. Sioak-Brjk, G., and Espevik, T. (1996). Application of alginate gels in biotechnology and biomedicine. Carbohydrates in Europe 14, 19-25.
16. Smidsrød, O. and Draget, K. I. (1996). Chemistry and physical properties of alginates. Carbohydrates in Europe 14, 6-13.
17. Smidsrød, O. and Skjåk-Bræk, G. (1990). Alginate as immobilization matrix for cells. Trends in Biotechnology 8, 71-78.
18. Vårum, K. M., Anthonsen, M. W., Grasdalen, H. and Smidsrød, O. (1991). 13C-N. m. r. studies of the acetylation sequences in partially N-deacetylated chitins (chilosans). Carbohydrate Research 217, 19-27.
19. Vårum, K. M, Anthonsen, M. W., Grasdalen, H. and Smidsrød, O. (1991). Determination of the degree of N-acetylation and the distribution of N-acetyl groups in partially N- deacetylated chitins (chitosans) by high-fieldn. m. r. spectroscopy. Carbohydrate Research 211, 17-23.
20. Weiner, M. L. (1992). An overview of the regulatory status and of the safety of chitin and chitosan as food and pharmaceutical ingredients. In Advances in Chitin and Chitosan. Eds. C J. Brine, P. A. Sandford and J. P. Zikakis, pp 663-670. Essex: Elsevier Science Publishers Limited.