Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo

Human Gene Therapy

Volumn 24, Issue 9, 2013, Pages 807-813

  Van Dijk, Remco ^a   Montenegro Miranda, Paula S ^a   Riviere, Christel ^b   Schilderink, Ronald ^a   Ten Bloemendaal, Lysbeth ^a   Van Gorp, Jacqueline ^a   Duijst, Suzanne ^a   De Waart, Dirk R ^a   Beuers, Ulrich ^a   Haisma, Hidde J ^c   Bosma, Piter J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b GÉNÉTHON   (France)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; GLUCURONOSYLTRANSFERASE; POLYINOSINIC ACID; SCAVENGER RECEPTOR A;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; CHO CELL; CONTROLLED STUDY; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; IN VITRO STUDY; LIVER DIRECTED GENE THERAPY; MACROPHAGE; MALE; NONHUMAN; RAT; VIRAL GENE THERAPY;

ANIMALS; BILIRUBIN; CELL LINE; CHO CELLS; CRICETULUS; CRIGLER-NAJJAR SYNDROME; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ENDOCYTOSIS; FEMALE; GENETIC THERAPY; GENETIC VECTORS; GLUCURONOSYLTRANSFERASE; HEK293 CELLS; HEPATOCYTES; HUMANS; KUPFFER CELLS; LIVER; MALE; POLY I; RATS; SCAVENGER RECEPTORS, CLASS A; TRANSDUCTION, GENETIC;

EID: 84883672073     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2013.086     Document Type: Article

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