Dissecting conformational contributions to glycosidase catalysis and inhibition

Current Opinion in Structural Biology

Volumn 28, Issue 1, 2014, Pages 1-13

  Speciale, Gaetano ^a   Thompson, Andrew J ^b   Davies, Gideon J ^b   Williams, Spencer J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; GLYCOSIDASE; LIGAND; OSELTAMIVIR; SUGAR; ZANAMIVIR; ALPHA 1,3 LEVO NEOAGAROBIASE; ALPHA MANNOSIDASE; BETA 1,3 XYLANASE; BETA GLUCOSIDE; BETA MANNOSIDASE; BETA N ACETYLHEXOSAMINIDASE; BETA XYLOSIDE; GALACTOSYLCERAMIDASE; LEVO IDURONIDASE; UNCLASSIFIED DRUG; VIRUS SIALIDASE; XYLAN ENDO 1,3 BETA XYLOSIDASE; ENZYME INHIBITOR; MANNOSE; PROTEIN BINDING; SIALIDASE;

BINDING AFFINITY; CATALYSIS; CLASSIFICATION; CONFORMATIONAL TRANSITION; DRUG STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; HUMAN; LIGAND BINDING; MICHAELIS CONSTANT; PRIORITY JOURNAL; REVIEW; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY; CALCULATION; COMPLEX FORMATION; CRYSTALLIZATION; ELECTROPHILICITY; ENZYME MECHANISM; ENZYME SUBSTRATE; FREE ENERGY LANDSCAPE; MICHAELIS COMPLEX; MOLECULAR MECHANICS; NONHUMAN; NUCLEOPHILICITY; QUANTUM MECHANICS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; MOLECULAR MIMICRY; PROTEIN CONFORMATION;

CARBOHYDRATES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; MANNOSE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; NEURAMINIDASE; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 84904054133     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2014.06.003     Document Type: Review

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