Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 3, 2012, Pages 781-786

  Thompson, Andrew J ^a   Williams, Rohan J ^b   Hakki, Zalihe ^b   Alonzi, Dominic S ^c   Wennekes, Tom ^d   Gloster, Tracey M ^a   Songsrirote, Kriangsak ^a   Thomas Oates, Jane E ^a   Wrodnigg, Tanja M ^e   Spreitz, Josef ^e   Stuẗz, Arnold E ^e   Butters, Terry D ^c   Williams, Spencer J ^b   Davies, Gideon J ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d WAGENINGEN UNIVERSITY   (Netherlands)

^e GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

3D structure; Enzyme inhibition; Enzyme mechanism; Glycobiology; Glycosidase

Indexed keywords

ALPHA MANNOSIDASE; BACTERIAL ENZYME; GLYCOPEPTIDASE; N ACETYLGLUCOSAMINE;

ARTICLE; BACTEROIDES THETAIOTAOMICRON; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN PROCESSING; STEREOCHEMISTRY; THREE DIMENSIONAL IMAGING;

ALPHA-MANNOSIDASE; BACTEROIDES; BIOCATALYSIS; CARBOHYDRATE CONFORMATION; CATALYTIC DOMAIN; CONSERVED SEQUENCE; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; POLYSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STATIC ELECTRICITY;

BACTERIA (MICROORGANISMS);

EID: 84863069740     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111482109     Document Type: Article

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