Human α-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 36, 2013, Pages 14628-14633

  Maita, Nobuo ^a   Tsukimura, Takahiro ^b   Taniguchi, Takako ^a   Saito, Seiji ^c   Ohno, Kazuki ^d   Taniguchi, Hisaaki ^a   Sakuraba, Hitoshi ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^c HOKKAIDO INFORMATION UNIVERSITY   (Japan)

^d NPO for the Promotion of Research on Intellectual Property Tokyo   (Japan)

Author keywords

Glycoside hydrolase family 39; N linked glycan; X ray crystallography

Indexed keywords

GLYCAN; LEVO IDURONIDASE; MANNOSE; DERMATAN SULFATE; HEPARAN SULFATE; POLYSACCHARIDE; PROTEIN BINDING;

ARTICLE; CATALYST; CHO CELL; CRYSTALLIZATION; DEGLYCOSYLATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME STRUCTURE; HUMAN; HURLER SYNDROME; PRIORITY JOURNAL; PROTEIN FUNCTION; AMINO ACID SEQUENCE; BINDING SITE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; BIOCATALYSIS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DERMATAN SULFATE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HEPARITIN SULFATE; HUMANS; IDURONIDASE; KINETICS; MANNOSE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUCOPOLYSACCHARIDOSIS I; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84883376707     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306939110     Document Type: Article

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