Transient receptor potential melastatin 7 (TRPM7) contributes to H 2O2-induced cardiac fibrosis via mediating Ca2+ influx and extracellular signal-regulated kinase 1/2 (ERK1/2) activation in cardiac fibroblasts

Journal of Pharmacological Sciences

Volumn 125, Issue 2, 2014, Pages 184-192

  Guo, Jin Lei ^a   Yu, Yang ^a   Jia, Yan Yan ^a   Ma, Yun Zi ^a   Zhang, Bo Yu ^a   Liu, Pei Qing ^a   Chen, Shao Rui ^a   Jiang, Jian Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Cardiac fibrosis; Extracellular signal regulated kinase 1 2 (ERK1 2); Transient receptor potential melastatin 7 (TRPM7)

Indexed keywords

2 AMINOETHOXYDIPHENYLBORANE; ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CALCIUM ION; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 7; ACTIN; CALCIUM; CTGF PROTEIN, RAT; SMALL INTERFERING RNA; SMOOTH MUSCLE ACTIN, RAT; TRANSFORMING GROWTH FACTOR BETA; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM7 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE SILENCING; HEART MUSCLE FIBROSIS; MALE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; RNA INTERFERENCE; UPREGULATION; ANIMAL; CELL CULTURE; FIBROSIS; GENETICS; HEART MUSCLE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; CALCIUM; CELLS, CULTURED; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTINS; FIBROSIS; HYDROGEN PEROXIDE; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIUM; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFORMING GROWTH FACTOR BETA; TRPM CATION CHANNELS;

EID: 84904025288     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13224FP     Document Type: Article

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