TRPM7 Ion Channels Are Required for Sustained Phosphoinositide 3-Kinase Signaling in Lymphocytes

Cell Metabolism

Volumn 8, Issue 1, 2008, Pages 84-93

  Sahni, Jaya ^a   Scharenberg, Andrew M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

CELLCYCLE; HUMDISEASE

Indexed keywords

MAGNESIUM ION; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL CHANNEL M7;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; GROWTH REGULATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; CELL PROLIFERATION; CHICKENS; LYMPHOCYTES; MAGNESIUM; SIGNAL TRANSDUCTION; TRPM CATION CHANNELS;

EID: 45549097202     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2008.06.002     Document Type: Article

References (22)

1. Allison A.C., Hovi T., Watts R.W., and Webster A.D. The role of de novo purine synthesis in lymphocyte transformation. Ciba Found. Symp. 48 (1977) 207-224
2. Auger K.R., Wang J., Narsimhan R.P., Holcombe T., and Roberts T.M. Constitutive cellular expression of PI 3-kinase is distinct from transient expression. Biochem. Biophys. Res. Commun. 272 (2000) 822-829
3. Bhaskar P.T., and Hay N. The two TORCs and Akt. Dev. Cell 12 (2007) 487-502
4. Cooper S. Control and maintenance of mammalian cell size. BMC Cell Biol. 5 (2004) 35
5. Dangi S., Cha H., and Shapiro P. Requirement for phosphatidylinositol-3 kinase activity during progression through S-phase and entry into mitosis. Cell. Signal. 15 (2003) 667-675
6. Dhillon A.S., Hagan S., Rath O., and Kolch W. MAP kinase signalling pathways in cancer. Oncogene 26 (2007) 3279-3290
7. Didichenko S.A., Tilton B., Hemmings B.A., Ballmer-Hofer K., and Thelen M. Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase. Curr. Biol. 6 (1996) 1271-1278
8. Frauwirth K.A., and Thompson C.B. Regulation of T lymphocyte metabolism. J. Immunol. 172 (2004) 4661-4665
9. Hawkins P.T., Anderson K.E., Davidson K., and Stephens L.R. Signalling through Class I PI3Ks in mammalian cells. Biochem. Soc. Trans. 34 (2006) 647-662
10. Klippel A., Reinhard C., Kavanaugh W.M., Apell G., Escobedo M.A., and Williams L.T. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol. 16 (1996) 4117-4127
11. Kohn A.D., Summers S.A., Birnbaum M.J., and Roth R.A. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271 (1996) 31372-31378
12. Pogue S.L., Kurosaki T., Bolen J., and Herbst R. B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase. J. Immunol. 165 (2000) 1300-1306
13. Roose J.P., Mollenauer M., Ho M., Kurosaki T., and Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol. Cell. Biol. 27 (2007) 2732-2745
14. Sahni J., Nelson B., and Scharenberg A.M. SLC41A2 encodes a plasma-membrane Mg2+ transporter. Biochem. J. 401 (2007) 505-513
15. Schmitz C., Deason F., and Perraud A.L. Molecular components of vertebrate Mg2+-homeostasis regulation. Magnes. Res. 20 (2007) 6-18
16. Schmitz C., Perraud A.L., Johnson C.O., Inabe K., Smith M.K., Penner R., Kurosaki T., Fleig A., and Scharenberg A.M. Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell 114 (2003) 191-200
17. Schmitz C., Perraud A.L., Fleig A., and Scharenberg A.M. Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr. Res. 55 (2004) 734-737
18. Shah O.J., and Hunter T. Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex. J. Biol. Chem. 279 (2004) 20816-20823
19. Shtivelman E., Sussman J., and Stokoe D. A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr. Biol. 12 (2002) 919-924
20. Takaya J., Higashino H., and Kobayashi Y. Can magnesium act as a second messenger? Current data on translocation induced by various biologically active substances. Magnes. Res. 13 (2000) 139-146
21. Woodgett J.R. Recent advances in the protein kinase B signaling pathway. Curr. Opin. Cell Biol. 17 (2005) 150-157
22. Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484