Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Zhen, Yunmei ^a,b   Qin, Guangrong ^b   Luo, Cheng ^b   Jiang, Hualiang ^b   Yu, Kunqian ^b   Chen, Guanghui ^a  

^a SHANTOU UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; RING FINGER PROTEIN; RNF4 PROTEIN; SUMO 2 PROTEIN; THIOESTER; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; PROTEIN BINDING; SUMO PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL BOND; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEPROTONATION; ENZYME SUBSTRATE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; NUCLEOPHILICITY; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; PROTON TRANSPORT; QUANTUM MECHANICS; STRUCTURE ANALYSIS; UBIQUITINATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN CONFORMATION; RING FINGER MOTIF;

MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; RING FINGER DOMAINS; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84903897029     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101663     Document Type: Article

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