A complete, multi-level conformational clustering of antibody complementarity-determining regions

PeerJ

Volumn 2014, Issue 1, 2014, Pages

  Nikoloudis, Dimitris ^a   Pitts, Jim E ^a   Saldanha, José W ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Antibody structure; Canonical model; CDR conformation; Clustering; Dynamic hybrid tree cut; Humanisation; Nested architecture; Prediction; Redundant repertoire

Indexed keywords

IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

AMINO TERMINAL SEQUENCE; ANTIBODY ENGINEERING; ANTIBODY STRUCTURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLUSTER ANALYSIS; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; HUMAN; INTERMETHOD COMPARISON; MULTIDIMENSIONAL SCALING; NONHUMAN; PHYLOGENETIC TREE; PLOTS AND CURVES; POPULATION STRUCTURE; POSITION WEIGHT MATRIX; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAMACHANDRAN PLOT; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

EID: 84903838044     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.456     Document Type: Article

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