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Volumn , Issue , 2009, Pages 3-19

Humanization of recombinant antibodies

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EID: 84880111000     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511596773.004     Document Type: Chapter
Times cited : (5)

References (74)
  • 1
    • 0031558798 scopus 로고    scopus 로고
    • Standard conformations for the canonical structure of immunoglobulins
    • Al-Lazikani B, Lesk AM, Chothia C. (1997) Standard conformations for the canonical structure of immunoglobulins. J. Mol. Biol. 273, 927-48.
    • (1997) J. Mol. Biol , vol.273 , pp. 927-948
    • Al-Lazikani, B.1    Lesk, A.M.2    Chothia, C.3
  • 2
    • 0030993418 scopus 로고    scopus 로고
    • Antibody humanization using monovalent phage display
    • Baca M, Presta LG, O'Connor SJ, Wells JA. (1997) Antibody humanization using monovalent phage display. J. Biol. Chem. 272, 10678-84.
    • (1997) J. Biol. Chem , vol.272 , pp. 10678-10684
    • Baca, M.1    Presta, L.G.2    O'Connor, S.J.3    Wells, J.A.4
  • 3
    • 0021713342 scopus 로고
    • Production of functional chimaeric mouse/human antibody
    • Boulianne GL, Hozumi N, Shulman MJ. (1984) Production of functional chimaeric mouse/human antibody. Nature. 312, 643-6.
    • (1984) Nature , vol.312 , pp. 643-646
    • Boulianne, G.L.1    Hozumi, N.2    Shulman, M.J.3
  • 8
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions of immunoglobulins
    • Chothia C, Lesk AM. (1987) Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196, 901-17.
    • (1987) J. Mol. Biol , vol.196 , pp. 901-917
    • Chothia, C.1    Lesk, A.M.2
  • 9
    • 0022339938 scopus 로고
    • Domain association in immunoglobulin molecules. The packing of variable domains
    • Chothia C, Novotny J, Bruccoleri R, Karplus M. (1985) Domain association in immunoglobulin molecules. The packing of variable domains. J. Mol. Biol. 186, 651-63.
    • (1985) J. Mol. Biol , vol.186 , pp. 651-663
    • Chothia, C.1    Novotny, J.2    Bruccoleri, R.3    Karplus, M.4
  • 11
    • 0027434029 scopus 로고
    • Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody
    • Co MS, Scheinberg DA, Avdalovic NM, McGraw K, Vasquez M, Caron PC, Queen C. (1993) Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody. Mol. Immunol. 30, 1361-7.
    • (1993) Mol. Immunol , vol.30 , pp. 1361-1367
    • Co, M.S.1    Scheinberg, D.A.2    Avdalovic, N.M.3    McGraw, K.4    Vasquez, M.5    Caron, P.C.6    Queen, C.7
  • 13
    • 33947096424 scopus 로고    scopus 로고
    • Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties
    • Damschroder MM, Widjaja L, Gill PS, Krasnoperov V, Jiang W, Dall'Acqua WF, Wu H. (2007) Framework shuffling of antibodies to reduce immunogenicity and manipulate functional and biophysical properties. Mol. Immunol. 44, 3049-60.
    • (2007) Mol. Immunol , vol.44 , pp. 3049-3060
    • Damschroder, M.M.1    Widjaja, L.2    Gill, P.S.3    Krasnoperov, V.4    Jiang, W.5    Dall'Acqua, W.F.6    Wu, H.7
  • 14
    • 0025847725 scopus 로고
    • Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte integrins
    • Daugherty BL, DeMartino JA, Law MF, Kawka DW, Singer II, Mark GE. (1991) Polymerase chain reaction facilitates the cloning, CDR-grafting, and rapid expression of a murine monoclonal antibody directed against the CD18 component of leukocyte integrins. Nucleic Acids Res. 19, 2471-6.
    • (1991) Nucleic Acids Res , vol.19 , pp. 2471-2476
    • Daugherty, B.L.1    DeMartino, J.A.2    Law, M.F.3    Kawka, D.W.4    Singer, I.I.5    Mark, G.E.6
  • 17
    • 3142550714 scopus 로고    scopus 로고
    • SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
    • Gonzales NR, Padlan EA, De Pascalis R, Schuck P, Schlom J, Kashmiri SV. (2004) SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity. Mol. Immunol. 41, 863-72.
    • (2004) Mol. Immunol , vol.41 , pp. 863-872
    • Gonzales, N.R.1    Padlan, E.A.2    De Pascalis, R.3    Schuck, P.4    Schlom, J.5    Kashmiri, S.V.6
  • 22
    • 11844305190 scopus 로고    scopus 로고
    • Limiting the risk of immunogenicity by identification and removal of T-cell epitopes (DeImmunisation™)
    • Hellendoorn K, Jones T, Watkins J, Baker M, Hamilton A, Carr F. (2004) Limiting the risk of immunogenicity by identification and removal of T-cell epitopes (DeImmunisation™). Cancer Cell Intl. 4, S20.
    • (2004) Cancer Cell Intl , vol.4
    • Hellendoorn, K.1    Jones, T.2    Watkins, J.3    Baker, M.4    Hamilton, A.5    Carr, F.6
  • 23
    • 17644378667 scopus 로고    scopus 로고
    • Immunogenicity of engineered antibodies
    • Hwang WY, Foote J. (2005) Immunogenicity of engineered antibodies. Methods 36, 3-10.
    • (2005) Methods , vol.36 , pp. 3-10
    • Hwang, W.Y.1    Foote, J.2
  • 24
    • 0022534172 scopus 로고
    • Monoclonal antibody therapy. Anti-idiotypic and non-anti-idiotypic antibodies to OKT3 arising despite intense immunosuppression
    • Jaffers GJ, Fuller TC, Cosimi AB, Russell PS, Winn HJ, Colvin RB. (1986) Monoclonal antibody therapy. Anti-idiotypic and non-anti-idiotypic antibodies to OKT3 arising despite intense immunosuppression. Transplantation 41, 572-8.
    • (1986) Transplantation , vol.41 , pp. 572-578
    • Jaffers, G.J.1    Fuller, T.C.2    Cosimi, A.B.3    Russell, P.S.4    Winn, H.J.5    Colvin, R.B.6
  • 26
    • 0028141993 scopus 로고
    • Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen
    • Jespers LS, Roberts A, Mahler SM, Winter G, Hoogenboom HR. (1994) Guiding the selection of human antibodies from phage display repertoires to a single epitope of an antigen. Biotechnology 12, 899-903.
    • (1994) Biotechnology , vol.12 , pp. 899-903
    • Jespers, L.S.1    Roberts, A.2    Mahler, S.M.3    Winter, G.4    Hoogenboom, H.R.5
  • 27
    • 0022558297 scopus 로고
    • Replacing the complementaritydetermining regions in a human antibody with those from a mouse
    • Jones PT, Dear PH, Foote J, Neuberger MS, Winter G. (1986) Replacing the complementaritydetermining regions in a human antibody with those from a mouse. Nature 321, 522-5.
    • (1986) Nature , vol.321 , pp. 522-525
    • Jones, P.T.1    Dear, P.H.2    Foote, J.3    Neuberger, M.S.4    Winter, G.5
  • 28
    • 0025270366 scopus 로고
    • Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy inmalignant and immune disorders
    • Junghans RP, Waldmann TA, Landolfi NF, Avdalovic NM, SchneiderWP, Queen C. (1990) Anti-Tac-H, a humanized antibody to the interleukin 2 receptor with new features for immunotherapy inmalignant and immune disorders. Cancer Res. 50, 1495-502.
    • (1990) Cancer Res , vol.50 , pp. 1495-1502
    • Junghans, R.P.1    Waldmann, T.A.2    Landolfi, N.F.3    Avdalovic, N.M.4    Schneider, W.P.5    Queen, C.6
  • 31
    • 0026094165 scopus 로고
    • Humanization of a mouse monoclonal antibody by CDR-grafting: The importance of framework residues on loop conformation
    • Kettleborough CA, Saldanha J, Heath VJ, Morrison CJ, Bendig MM. (1991) Humanization of a mouse monoclonal antibody by CDR-grafting: the importance of framework residues on loop conformation. Protein Eng. 4, 773-83.
    • (1991) Protein Eng , vol.4 , pp. 773-783
    • Kettleborough, C.A.1    Saldanha, J.2    Heath, V.J.3    Morrison, C.J.4    Bendig, M.M.5
  • 32
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Köhler G, Milstein C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-7.
    • (1975) Nature , vol.256 , pp. 495-497
    • Köhler, G.1    Milstein, C.2
  • 33
    • 0027364063 scopus 로고
    • Humanization of a mouse anti-human IgE antibody: A potential therapeutic for IgE-mediated allergies
    • Kolbinger F, Saldanha J, Hardman N, Bendig MM. (1993) Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. Protein Eng. 6, 971-80.
    • (1993) Protein Eng , vol.6 , pp. 971-980
    • Kolbinger, F.1    Saldanha, J.2    Hardman, N.3    Bendig, M.M.4
  • 34
    • 34249017414 scopus 로고    scopus 로고
    • A molecular immunology approach to antibody humanization and functional optimization
    • Lazar GA, Desjarlais JR, Jacinto J, Karki S, Hammond PW. (2007) A molecular immunology approach to antibody humanization and functional optimization. Mol. Immunol. 44, 1986-1998.
    • (2007) Mol. Immunol , vol.44 , pp. 1986-1998
    • Lazar, G.A.1    Desjarlais, J.R.2    Jacinto, J.3    Karki, S.4    Hammond, P.W.5
  • 36
    • 33644857980 scopus 로고    scopus 로고
    • Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
    • Li J, Sai T, Berger M, Chao Q, Davidson D, et al. (2006) Human antibodies for immunotherapy development generated via a human B cell hybridoma technology. Proc. Natl. Acad. Sci. U.S.A. 103, 3557-62.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 3557-3562
    • Li, J.1    Sai, T.2    Berger, M.3    Chao, Q.4    Davidson, D.5
  • 39
    • 0025226085 scopus 로고
    • Phage antibodies: Filamentous phage displaying antibody variable domains
    • McCafferty J, Griffiths AD, Winter G, Chiswell DJ. (1990) Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-4.
    • (1990) Nature , vol.348 , pp. 552-554
    • McCafferty, J.1    Griffiths, A.D.2    Winter, G.3    Chiswell, D.J.4
  • 41
    • 0021716682 scopus 로고
    • Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains
    • Morrison SL, Johnson MJ, Herzenberg LA, Oi VT. (1984) Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. U.S.A. 81, 6851-5.
    • (1984) Proc. Natl. Acad. Sci. U.S.A , vol.81 , pp. 6851-6855
    • Morrison, S.L.1    Johnson, M.J.2    Herzenberg, L.A.3    Oi, V.T.4
  • 42
    • 0034877794 scopus 로고    scopus 로고
    • Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody
    • Nakamura K, Tanaka Y, Fujino I, Hirayama N, Shitara K, Hanai N. (2000) Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody. Mol. Immunol. 37, 1035-46.
    • (2000) Mol. Immunol , vol.37 , pp. 1035-1046
    • Nakamura, K.1    Tanaka, Y.2    Fujino, I.3    Hirayama, N.4    Shitara, K.5    Hanai, N.6
  • 45
    • 0029981792 scopus 로고    scopus 로고
    • Light chain shuffling of a high affinity antibody results in a drift in epitope recognition
    • Ohlin M, Owman H, Mach M, Borrebaeck CA. (1996) Light chain shuffling of a high affinity antibody results in a drift in epitope recognition. Mol. Immunol. 33, 47-56.
    • (1996) Mol. Immunol , vol.33 , pp. 47-56
    • Ohlin, M.1    Owman, H.2    Mach, M.3    Borrebaeck, C.A.4
  • 46
    • 0028798104 scopus 로고
    • Identification of specificity-determining residues in antibodies
    • Padlan EA, Abergel C, Tipper JP. (1995) Identification of specificity-determining residues in antibodies. FASEB J. 9, 133-9.
    • (1995) FASEB J , vol.9 , pp. 133-139
    • Padlan, E.A.1    Abergel, C.2    Tipper, J.P.3
  • 47
    • 0025848797 scopus 로고
    • A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties
    • Padlan EA. (1991) A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties. Mol. Immunol. 28, 489-98.
    • (1991) Mol. Immunol , vol.28 , pp. 489-498
    • Padlan, E.A.1
  • 48
    • 0028289241 scopus 로고
    • Anatomy of the antibody molecule
    • Padlan EA. (1994) Anatomy of the antibody molecule. Mol. Immunol. 31, 169-217.
    • (1994) Mol. Immunol , vol.31 , pp. 169-217
    • Padlan, E.A.1
  • 49
    • 0027955786 scopus 로고
    • Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies
    • Pedersen JT, Henry AH, Searle SJ, Guild BC, Roguska M, Rees AR. (1994) Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies. J. Mol. Biol. 235, 959-73.
    • (1994) J. Mol. Biol , vol.235 , pp. 959-973
    • Pedersen, J.T.1    Henry, A.H.2    Searle, S.J.3    Guild, B.C.4    Roguska, M.5    Rees, A.R.6
  • 50
    • 0028895526 scopus 로고
    • Inhibition of T cell activation with a humanized anti-beta 1 integrin chain mAb
    • Poul MA, Ticchioni M, Bernard A, Lefranc MP. (1995) Inhibition of T cell activation with a humanized anti-beta 1 integrin chain mAb. Mol. Immunol. 32, 101-16.
    • (1995) Mol. Immunol , vol.32 , pp. 101-116
    • Poul, M.A.1    Ticchioni, M.2    Bernard, A.3    Lefranc, M.P.4
  • 52
    • 0032555214 scopus 로고    scopus 로고
    • A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries
    • Rader C, Cheresh DA, Barbas CF 3rd. (1998) A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries. Proc. Natl. Acad. Sci. U.S.A. 95, 8910-5.
    • (1998) Proc. Natl. Acad. Sci. U.S.A , vol.95 , pp. 8910-8915
    • Rader, C.1    Cheresh, D.A.2    Barbas, C.F.3
  • 54
    • 0026438009 scopus 로고
    • Engineering a humanized bispecific F(ab#)2 fragment for improved binding to T cells
    • Rodrigues ML, Shalaby MR, Werther W, Presta L, Carter P. (1992) Engineering a humanized bispecific F(ab#)2 fragment for improved binding to T cells. Int J Cancer Suppl. 7, 45-50.
    • (1992) Int J Cancer , pp. 45-50
    • Rodrigues, M.L.1    Shalaby, M.R.2    Werther, W.3    Presta, L.4    Carter, P.5
  • 56
    • 0033178126 scopus 로고    scopus 로고
    • A single backmutation in the human kIV framework of a previously unsuccessfully humanized antibody restores the binding activity and increases the secretion in cos cells
    • Saldanha JW, Martin AC, Léger OJ. (1999) A single backmutation in the human kIV framework of a previously unsuccessfully humanized antibody restores the binding activity and increases the secretion in cos cells. Mol. Immunol. 36, 709-19.
    • (1999) Mol. Immunol , vol.36 , pp. 709-719
    • Saldanha, J.W.1    Martin, A.C.2    Léger, O.J.3
  • 59
    • 0028223116 scopus 로고
    • Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions
    • Sato K, Tsuchiya M, Saldanha J, Koishihara Y, Ohsugi Y, Kishimoto T, Bendig MM. (1994) Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions. Mol. Immunol. 31, 371-81.
    • (1994) Mol. Immunol , vol.31 , pp. 371-381
    • Sato, K.1    Tsuchiya, M.2    Saldanha, J.3    Koishihara, Y.4    Ohsugi, Y.5    Kishimoto, T.6    Bendig, M.M.7
  • 60
    • 0027159153 scopus 로고
    • The anti-idiotypic response by cynomolgus monkeys to humanized anti-Tac is primarily directed to complementarity-determining regions H1, H2, and L3
    • Schneider WP, Glaser SM, Kondas JA, Hakimi J. (1993) The anti-idiotypic response by cynomolgus monkeys to humanized anti-Tac is primarily directed to complementarity-determining regions H1, H2, and L3. J. Immunol. 150, 3086-90.
    • (1993) J. Immunol , vol.150 , pp. 3086-3090
    • Schneider, W.P.1    Glaser, S.M.2    Kondas, J.A.3    Hakimi, J.4
  • 61
    • 0021999401 scopus 로고
    • Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy
    • Schroff RW, Foon KA, Beatty SM, Oldham RK, Morgan AC Jr. (1985) Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res. 45, 879-85.
    • (1985) Cancer Res , vol.45 , pp. 879-885
    • Schroff, R.W.1    Foon, K.A.2    Beatty, S.M.3    Oldham, R.K.4    Morgan, A.C.5
  • 62
    • 0026346943 scopus 로고
    • Construction, expression and characterization of humanized antibodies directed against the human alpha/beta T cell receptor
    • Shearman CW, Pollock D, White G, Hehir K, Moore GP, Kanzy EJ, Kurrle R. (1991) Construction, expression and characterization of humanized antibodies directed against the human alpha/beta T cell receptor. J. Immunol. 147, 4366-73.
    • (1991) J. Immunol , vol.147 , pp. 4366-4373
    • Shearman, C.W.1    Pollock, D.2    White, G.3    Hehir, K.4    Moore, G.P.5    Kanzy, E.J.6    Kurrle, R.7
  • 63
    • 0030577371 scopus 로고    scopus 로고
    • Structural classification of CDR-H3 in antibodies
    • Shirai H, Kidera A, Nakamura H. (1996) Structural classification of CDR-H3 in antibodies. FEBS Lett. 399, 1-8.
    • (1996) FEBS Lett , vol.399 , pp. 1-8
    • Shirai, H.1    Kidera, A.2    Nakamura, H.3
  • 64
    • 0033058759 scopus 로고    scopus 로고
    • H3-rules: Identification of CDR-H3 structures in antibodies
    • Shirai H, Kidera A, Nakamura H. (1999) H3-rules: identification of CDR-H3 structures in antibodies. FEBS Lett. 455, 188-97.
    • (1999) FEBS Lett , vol.455 , pp. 188-197
    • Shirai, H.1    Kidera, A.2    Nakamura, H.3
  • 65
    • 30344474589 scopus 로고    scopus 로고
    • Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modeling of variable domains
    • Staelens S, Desmet J, Ngo TH, Vauterin S, Pareyn I, Barbeaux P, Van Rompaey I, Stassen JM, Deckmyn H, Vanhoorelbeke K. (2006) Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modeling of variable domains. Mol. Immunol. 43, 1243-57.
    • (2006) Mol. Immunol , vol.43 , pp. 1243-1257
    • Staelens, S.1    Desmet, J.2    Ngo, T.H.3    Vauterin, S.4    Pareyn, I.5    Barbeaux, P.6    Van Rompaey, I.7    Stassen, J.M.8    Deckmyn, H.9    Vanhoorelbeke, K.10
  • 66
    • 0037100379 scopus 로고    scopus 로고
    • "Superhumanized" antibodies: Reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: Application to an anti-CD28
    • Tan P, Mitchell DA, Buss TN, Holmes MA, Anasetti C, Foote J. (2002) "Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28. J. Immunol. 169, 1119-25.
    • (2002) J. Immunol , vol.169 , pp. 1119-1125
    • Tan, P.1    Mitchell, D.A.2    Buss, T.N.3    Holmes, M.A.4    Anasetti, C.5    Foote, J.6
  • 67
    • 0028935437 scopus 로고
    • Identification of framework residues required to restore antigen binding during reshaping of a monoclonal antibody against the glycoprotein gB of human cytomegalovirus
    • Tempest PR, White P, Buttle M, Carr FJ, Harris WJ. (1995) Identification of framework residues required to restore antigen binding during reshaping of a monoclonal antibody against the glycoprotein gB of human cytomegalovirus. Int. J. Biol. Macromol. 17, 37-42.
    • (1995) Int. J. Biol. Macromol , vol.17 , pp. 37-42
    • Tempest, P.R.1    White, P.2    Buttle, M.3    Carr, F.J.4    Harris, W.J.5
  • 69
    • 0038306259 scopus 로고    scopus 로고
    • An improved model of association for VH-VL immunoglobulin domains: Asymmetries between VH and VL in the packing of some interface residues
    • Vargas-Madrazo E, Paz-García E. (2003) An improved model of association for VH-VL immunoglobulin domains: asymmetries between VH and VL in the packing of some interface residues. J. Mol. Recognit. 16, 113-20.
    • (2003) J. Mol. Recognit , vol.16 , pp. 113-120
    • Vargas-Madrazo, E.1    Paz-García, E.2
  • 70
    • 0023920595 scopus 로고
    • Reshaping human antibodies: Grafting an antilysozyme activity
    • Verhoeyen M, Milstein C, Winter G. (1988) Reshaping human antibodies: grafting an antilysozyme activity. Science 239, 1534-6.
    • (1988) Science , vol.239 , pp. 1534-1536
    • Verhoeyen, M.1    Milstein, C.2    Winter, G.3
  • 71
    • 0033584995 scopus 로고    scopus 로고
    • Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues
    • Wu H, Nie Y, Huse WD, Watkins JD. (1999) Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues. J. Mol. Biol. 294, 151-62.
    • (1999) J. Mol. Biol , vol.294 , pp. 151-162
    • Wu, H.1    Nie, Y.2    Huse, W.D.3    Watkins, J.D.4
  • 72
    • 0014828908 scopus 로고
    • An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
    • Wu TT, Kabat EA. (1970) An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J. Exp. Med. 132, 211-50.
    • (1970) J. Exp. Med , vol.132 , pp. 211-250
    • Wu, T.T.1    Kabat, E.A.2
  • 74
    • 20444384772 scopus 로고    scopus 로고
    • Humanization of an anti-human TNF-alpha antibody by variable region resurfacing with the aid of molecular modeling
    • Zhang W, Feng J, Li Y, Guo N, Shen B. (2005) Humanization of an anti-human TNF-alpha antibody by variable region resurfacing with the aid of molecular modeling. Mol. Immunol. 42, 1445-51.
    • (2005) Mol. Immunol , vol.42 , pp. 1445-1451
    • Zhang, W.1    Feng, J.2    Li, Y.3    Guo, N.4    Shen, B.5


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