1-(1H-indol-3-yl)ethanamine derivatives as potent Staphylococcus aureus NorA efflux pump inhibitors

ChemMedChem

Volumn 9, Issue 7, 2014, Pages 1534-1545

  Hequet, Arnaud ^a   Burchak, Olga N ^b   Jeanty, Matthieu ^b,e   Guinchard, Xavier ^b,c   Le Pihive, Emmanuelle ^c   Maigre, Laure ^c   Bouhours, Pascale ^a   Schneider, Dominique ^c   Maurin, Max ^c,d   Paris, Jean Marc ^a   Denis, Jean Noël ^b   Jolivalt, Claude ^a  

^a PSL RESEARCH UNIVERSITY   (France)

^b Centre National de la Recherche Scientifique   (France)

^c CNRS   (France)

^d GRENOBLE UNIVERSITY HOSPITAL   (France)

^e NovAliX   (France)

Author keywords

antibiotics; efflux pumps; indoles; inhibitors; Staphylococcus aureus; structure activity relationships

Indexed keywords

1 (1H INDOL 3 YL)ETHANAMINE DERIVATIVE; ANTIINFECTIVE AGENT; CARRIER PROTEIN; CIPROFLOXACIN; ETHIDIUM BROMIDE; INDOLE DERIVATIVE; N (3 (( TERT BUTOXYCARBONYL)AMINO)PROPYLIDENE) 1 PHENYLMETHANAMINE OXIDE; NORA EFFLUX PUMP; QUINOLONE DERIVATIVE; TERT BUTYL (2 (1 BENZYL 3 HYDROXYUREIDO) 2 (5 BROMO 1H INDOL 3YL)ETHYL)CARBAMATE; TERT BUTYL (2 (3 HYDROXYUREIDO) 2 (1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 (4 BROMOPHENYL)ACETAMIDO 2 (5 BROMO 1H INDOL 3YL)ETHYL)CARBAMATE; TERT BUTYL (2 (5 BROMO 1H INDOL 3 YL) 2 (2,2,2 TRIFLUOROACETAMIDO)ETHYL)CARBAMATE; TERT BUTYL (2 (5 BROMO 1H INDOL 3 YL) 2 (NICOTINAMIDO)ETHYL)CARBAMATE; TERT BUTYL (2 (BENZYLAMINO) 2 (5 BROMO 1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 ACETAMIDO 2 (1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 ACETAMIDO 2 (5 BROMO 1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 AMINO 2 (1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 AMINO 2 (5 BROMO 1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 BENZAMIDO 2 (5 BROMO 1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 FORMAMIDO 2 (1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (2 FORMAMIDO 2 (5 BROMO 1H INDOL 3 YL)ETHYL)CARBAMATE; TERT BUTYL (3 (BENZYL(HYDROXY)AMINO) 3 (5 BROMO 1H INDOL 3 YL)PROPYL)CARBAMATE; TERT BUTYL (3 OXOPROPYL)CARBAMATE; UNCLASSIFIED DRUG; AMINE; BACTERIAL PROTEIN; INDOLE; MULTIDRUG RESISTANCE PROTEIN; NORA PROTEIN, STAPHYLOCOCCUS;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; COLON TUMOR; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LUNG FIBROBLAST; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

AMINES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CELL LINE; CELL PROLIFERATION; CIPROFLOXACIN; DRUG RESISTANCE, BACTERIAL; HUMANS; INDOLES; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903820842     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201400042     Document Type: Article

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