Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells

Cell Research

Volumn 24, Issue 7, 2014, Pages 820-841

  Sahara, Makoto ^a,b,c,d   Hansson, Emil M ^a,b   Wernet, Oliver ^e   Lui, Kathy O ^a,b,c   Später, Daniela ^a,b,c   Chien, Kenneth R ^a,b,d  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD STEM CELL INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

embryonic stem cell; endothelial progenitor; Notch signaling; VEGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CADHERIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; LEUKOCYTE ANTIGEN; NOTCH RECEPTOR; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; DRUG EFFECTS; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; PLURIPOTENT STEM CELL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD; BONE MORPHOGENETIC PROTEIN 4; CADHERINS; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; PLURIPOTENT STEM CELLS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84903818662     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.59     Document Type: Article

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