Generation of functional hemangioblasts from human embryonic stem cells

Nature Methods

Volumn 4, Issue 6, 2007, Pages 501-509

  Lu, Shi Jiang ^a   Feng, Qiang ^a   Caballero, Sergio ^b   Chen, Yu ^c   Moore, Malcolm A S ^c   Grant, Maria B ^b   Lanza, Robert ^a  

^a Advanced Cell Technology   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLAST CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYOPRESERVATION; DIABETES MELLITUS; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; GENE EXPRESSION; HEART INFARCTION; HEMANGIOBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMB BLOOD FLOW; LIMB ISCHEMIA; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; RETINA INJURY; RETINA ISCHEMIA; STEM CELL TRANSPLANTATION; TISSUE REPAIR;

ANIMALS; BLOOD VESSELS; CELL DIFFERENTIATION; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; EMBRYONIC STEM CELLS; HEMATOPOIETIC STEM CELLS; HINDLIMB; HUMANS; ISCHEMIA; MICE; MICE, INBRED NOD; MICE, SCID; MYOCARDIAL INFARCTION; RATS; REPERFUSION INJURY; STEM CELL TRANSPLANTATION;

MUS; RATTUS;

EID: 34249807324     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth1041     Document Type: Article

References (30)

1. Rafii, S. & Lyden, D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat. Med. 9, 702-712 (2003).
2. Grant, M.B. et al. Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization. Nat. Med. 8, 607-612 (2002).
3. Bailey, A.S. et al. Transplanted adult hematopoietic stems cells differentiate into functional endothelial cells. Blood 103, 13-19 (2004).
4. Cogle, C.R. et al. Adult human hematopoietic cells provide functional hemangioblast activity. Blood 103, 133-135 (2004).
5. Otani, A. et al. Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat. Med. 8, 1004-1010 (2002).
6. Crosby, J.R. et al. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ. Res. 87, 728-730 (2000).
7. Hill, J.M. et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N. Engl. J. Med. 348, 593-600 (2003).
8. Wagner, R.C. Endothelial cell embryology and growth. Adv. Microcirc. 9, 45-75 (1980).
9. Park, C., Ma, Y.D. & Choi, K. Evidence for the hemangioblast. Exp. Hematol. 33, 965-970 (2005).
10. Loges, S. et al. Identification of the adult human hemangioblast. Stem Cells Dev. 13, 229-242 (2004).
11. Pelosi, E. et al. Identification of the hemangioblast in postnatal life. Blood 100, 3203-3208 (2002).
12. Choi, K., Kennedy, M., Kazarov, A., Papadimitriou, J.C. & Keller, G. A common precursor for hematopoietic and endothelial cells. Development 125, 725-732 (1998).
13. Kennedy, M. et al. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature 386, 488-493 (1997).
14. Kennedy, M., D'Souza, S.L., Lynch-Kattman, M., Schwantz, S. & Keller, G. Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures. Blood 109, 2679-2687 (2007).
15. Tian, X., Morris, J.K., Linehan, J.L. & Kaufman, D.S. Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells. Exp. Hematol. 32, 1000-1009 (2004).
16. Bowles, K.M., Vallier, L., Smith, J.R., Alexander, M.R. & Pedersen, R.A. HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells. Stem Cells 24, 1359-1369 (2006).
17. Klimanskaya, I., Chung, Y., Becker, S., Lu, S-J. & Lanza, R. Human embryonic stem-cell lines derived from single blastomeres. Nature 444, 481-485 (2006).
18. D'Souza, S.L., Elefanty, A.G. & Keller, G. SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood 105, 3862-3870 (2005).
19. Gering, M., Yamada, Y., Rabbitts, T.H. & Patient, R.K. Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development 130, 6187-6199 (2003).
20. Lu, S-J., Li, F., Vida, L. & Honig, G.R. CD34+CD38- hematopoietic precursors derived from human embryonic stem cells exhibit an embryonic gene expression pattern. Blood 103, 4134-4141 (2004).
21. Zheng, L., Gong, B., Hatala, D.A. & Kern, T.S. Retinal ischemia and reperfusion causes capillary degeneration: Similarities to diabetes 32. Invest. Ophthalmol. Vis. Sci. 48, 361-367 (2007).
22. Asahara, T. et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964-967 (1997).
23. Murohara, T. et al. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization. J. Clin. Invest. 105, 1527-1536 (2000).
24. Yang, Y. et al. VEGF enhances functional improvement of postinfarcted hearts by transplantation of ESC-differentiated cells. J. Appl. Physiol. 93, 1140-1151 (2002).
25. Dowell, J.D., Rubart, M., Pasumarthi, K.B., Soonpaa, M.H. & Field, L.J. Myocyte and myogenic stem cell transplantation in the heart. Cardiovasc. Res. 58, 336-350 (2003).
26. Schatteman, G.C., Hanlon, H.D., Jiao, C., Dodds, S.G. & Christy, B.A. Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice. J. Clin. Invest. 106, 571-578 (2000).
27. Wang, L. et al. Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties. Immunity 21, 31-41 (2004).
28. Zambidis, E.T., Peault, B., Park, T.S., Bunz, F. & Civin, C.I. Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood 106, 860-870 (2005).
29. Umeda, K. et al. Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation. Stem Cells 24, 1348-1358 (2006).
30. Klimanskaya, I. & McMahon, J. Approaches of derivation and maintenance of human ES cells: Detailed procedures and alternatives. in Handbook of Stem Cells. Volume 1: Embryonic Stem Cells (eds., Lanza, R. et al.) 437-449 (Elsevier/Academic Press, San Diego, 2004).