TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration

Journal of Clinical Investigation

Volumn 124, Issue 7, 2014, Pages 3080-3092

  Liang, Chun Chi ^a   Tanabe, Lauren M ^a   Jou, Stephanie ^a   Chi, Frank ^a   Dauer, William T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; NESTIN; PROTEIN; PROTEIN DYT 1; TORSINA; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ABNORMAL POSTURE; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CENTRAL NERVOUS SYSTEM; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DIFFUSION TENSOR IMAGING; DYSTONIA; ENDOPLASMIC RETICULUM STRESS; FACIAL NERVE; GENE DELETION; GLIOSIS; GLOBUS PALLIDUS; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; INFERIOR OLIVE; MALE; MOLECULAR PATHOLOGY; MOTOR DYSFUNCTION; MOTOR NERVE; MOUSE; MUTANT; NERVE DEGENERATION; NEURAL STEM CELL; NONHUMAN; PHENOTYPE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSORIMOTOR CIRCUIT; SENSORIMOTOR CORTEX; SENSORY NERVE; SUBSTANTIA NIGRA PARS RETICULATA; TAIL SUSPENSION TEST; THALAMUS; UPREGULATION;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; DYSTONIA MUSCULORUM DEFORMANS; GENE KNOCKOUT TECHNIQUES; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MOLECULAR CHAPERONES; MOTOR NEURONS; MUTATION; NERVE DEGENERATION; SENSORY RECEPTOR CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 84903773326     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72830     Document Type: Article

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