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Volumn 19, Issue 7, 2014, Pages 1024-1029

Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RESVERATROL; SIRTUIN 1; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 84903766354     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.02.013     Document Type: Review
Times cited : (12)

References (64)
  • 1
    • 47949104798 scopus 로고    scopus 로고
    • The role of exercise and PGC1alpha in inflammation and chronic disease
    • C. Handschin, and B.M. Spiegelman The role of exercise and PGC1alpha in inflammation and chronic disease Nature 454 2008 463 469
    • (2008) Nature , vol.454 , pp. 463-469
    • Handschin, C.1    Spiegelman, B.M.2
  • 3
    • 84875642011 scopus 로고    scopus 로고
    • Physical activity in obesity and metabolic syndrome
    • B. Strasser Physical activity in obesity and metabolic syndrome Ann. N. Y. Acad. Sci. 1281 2013 141 159
    • (2013) Ann. N. Y. Acad. Sci. , vol.1281 , pp. 141-159
    • Strasser, B.1
  • 4
    • 84863855663 scopus 로고    scopus 로고
    • Therapeutic exercise in cancer cachexia
    • M. Maddocks et al. Therapeutic exercise in cancer cachexia Crit. Rev. Oncogen. 17 2012 285 292
    • (2012) Crit. Rev. Oncogen. , vol.17 , pp. 285-292
    • Maddocks, M.1
  • 5
    • 79953063911 scopus 로고    scopus 로고
    • Exercise and Duchenne muscular dystrophy: Toward evidence-based exercise prescription
    • C.D. Markert et al. Exercise and Duchenne muscular dystrophy: toward evidence-based exercise prescription Muscle Nerve 43 2011 464 478
    • (2011) Muscle Nerve , vol.43 , pp. 464-478
    • Markert, C.D.1
  • 6
    • 69949162866 scopus 로고    scopus 로고
    • Novel pharmacological approaches to combat obesity and insulin resistance: Targeting skeletal muscle with 'exercise mimetics'
    • A.L. Carey, and B.A. Kingwell Novel pharmacological approaches to combat obesity and insulin resistance: targeting skeletal muscle with 'exercise mimetics' Diabetologia 52 2009 2015 2026
    • (2009) Diabetologia , vol.52 , pp. 2015-2026
    • Carey, A.L.1    Kingwell, B.A.2
  • 7
    • 84873378527 scopus 로고    scopus 로고
    • Exercise metabolism and the molecular regulation of skeletal muscle adaptation
    • B. Egan, and J.R. Zierath Exercise metabolism and the molecular regulation of skeletal muscle adaptation Cell Metab. 17 2013 162 184
    • (2013) Cell Metab. , vol.17 , pp. 162-184
    • Egan, B.1    Zierath, J.R.2
  • 8
    • 84870606130 scopus 로고    scopus 로고
    • Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle
    • M. Catoire et al. Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle PLoS ONE 7 2012 e51066
    • (2012) PLoS ONE , vol.7 , pp. 51066
    • Catoire, M.1
  • 9
    • 77954909425 scopus 로고    scopus 로고
    • PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity
    • V.A. Lira et al. PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity Am. J. Physiol. Endocrinol. Metab. 299 2010 E145 E161
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299
    • Lira, V.A.1
  • 10
    • 10744228606 scopus 로고    scopus 로고
    • Endurance Training in Humans Leads to Fiber Type-Specific Increases in Levels of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 and Peroxisome Proliferator-Activated Receptor-α in Skeletal Muscle
    • DOI 10.2337/diabetes.52.12.2874
    • A.P. Russell et al. Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle Diabetes 52 2003 2874 2881 (Pubitemid 37466855)
    • (2003) Diabetes , vol.52 , Issue.12 , pp. 2874-2881
    • Russell, A.P.1    Feilchenfeldt, J.2    Schreiber, S.3    Praz, M.4    Crettenand, A.5    Gobelet, C.6    Meier, C.A.7    Bell, D.R.8    Kralli, A.9    Giacobino, J.-P.10    Deriaz, O.11
  • 11
  • 12
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • D.G. Hardie et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis Nat. Rev. Mol. Cell Biol. 13 2012 251 262
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 251-262
    • Hardie, D.G.1
  • 13
    • 76849083600 scopus 로고    scopus 로고
    • AMPK-mediated regulation of transcription in skeletal muscle
    • S.L. McGee, and M. Hargreaves AMPK-mediated regulation of transcription in skeletal muscle Clin. Sci. 118 2010 507 518
    • (2010) Clin. Sci. , vol.118 , pp. 507-518
    • McGee, S.L.1    Hargreaves, M.2
  • 14
    • 84861885100 scopus 로고    scopus 로고
    • NAD(1)/NADH and skeletal muscle mitochondrial adaptations to exercise
    • A.T. White, and S. Schenk NAD(1)/NADH and skeletal muscle mitochondrial adaptations to exercise Am. J. Physiol. Endocrinol. Metab. 303 2012 E308 E321
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.303
    • White, A.T.1    Schenk, S.2
  • 16
    • 79960286947 scopus 로고    scopus 로고
    • Obesity impairs skeletal muscle AMPK signaling during exercise: Role of AMPKalpha2 in the regulation of exercise capacity in vivo
    • R.S. Lee-Young et al. Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKalpha2 in the regulation of exercise capacity in vivo Int. J. Obesity 35 2011 982 989
    • (2011) Int. J. Obesity , vol.35 , pp. 982-989
    • Lee-Young, R.S.1
  • 17
    • 33748612432 scopus 로고    scopus 로고
    • AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model
    • S. Giri et al. AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model Nutr. Metab. 3 2006 31
    • (2006) Nutr. Metab. , vol.3 , pp. 31
    • Giri, S.1
  • 18
    • 66149135126 scopus 로고    scopus 로고
    • Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status
    • J.A. Babraj et al. Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status Am. J. Physiol. Endocrinol. Metab. 296 2009 E1042 E1048
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Babraj, J.A.1
  • 19
    • 79251569246 scopus 로고    scopus 로고
    • Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1alpha mRNA: A role of beta(2)-adrenergic receptor activation
    • M. Tadaishi et al. Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1alpha mRNA: a role of beta(2)-adrenergic receptor activation Am. J. Physiol. Endocrinol. Metab. 300 2011 E341 E349
    • (2011) Am. J. Physiol. Endocrinol. Metab. , vol.300
    • Tadaishi, M.1
  • 20
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPARdelta agonists are exercise mimetics
    • V.A. Narkar et al. AMPK and PPARdelta agonists are exercise mimetics Cell 134 2008 405 415
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1
  • 21
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • S. Jager et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha Proc. Natl. Acad. Sci. U. S. A. 104 2007 12017 12022
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 12017-12022
    • Jager, S.1
  • 22
    • 80053519193 scopus 로고    scopus 로고
    • Angiotensin II upregulates protein phosphatase 2Calpha and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting
    • A.M. Tabony et al. Angiotensin II upregulates protein phosphatase 2Calpha and inhibits AMP-activated protein kinase signaling and energy balance leading to skeletal muscle wasting Hypertension 58 2011 643 649
    • (2011) Hypertension , vol.58 , pp. 643-649
    • Tabony, A.M.1
  • 23
    • 77953495952 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy
    • J.J. Brault et al. Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy J. Biol. Chem. 285 2010 19460 19471
    • (2010) J. Biol. Chem. , vol.285 , pp. 19460-19471
    • Brault, J.J.1
  • 24
    • 80051692198 scopus 로고    scopus 로고
    • Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle
    • V. Ljubicic et al. Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle Hum. Mol. Genet. 20 2011 3478 3493
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3478-3493
    • Ljubicic, V.1
  • 25
    • 84867920817 scopus 로고    scopus 로고
    • Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model
    • V.E. Jahnke et al. Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model Skelet. Muscle 2 2012 16
    • (2012) Skelet. Muscle , vol.2 , pp. 16
    • Jahnke, V.E.1
  • 26
    • 84864124772 scopus 로고    scopus 로고
    • AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm
    • M. Pauly et al. AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm Am. J. Pathol. 181 2012 583 592
    • (2012) Am. J. Pathol. , vol.181 , pp. 583-592
    • Pauly, M.1
  • 27
    • 84866648580 scopus 로고    scopus 로고
    • Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance
    • C.R. Bueno Junior et al. Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance PLoS ONE 7 2012 e45699
    • (2012) PLoS ONE , vol.7 , pp. 45699
    • Bueno Junior, C.R.1
  • 30
    • 84861714642 scopus 로고    scopus 로고
    • Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats
    • V.W. Dolinsky et al. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats J. Physiol. 590 2012 2783 2799
    • (2012) J. Physiol. , vol.590 , pp. 2783-2799
    • Dolinsky, V.W.1
  • 31
    • 84874925761 scopus 로고    scopus 로고
    • Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis
    • K.J. Menzies et al. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis J. Biol. Chem. 288 2013 6968 6979
    • (2013) J. Biol. Chem. , vol.288 , pp. 6968-6979
    • Menzies, K.J.1
  • 32
    • 84875431034 scopus 로고    scopus 로고
    • High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
    • M.M. Poulsen et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition Diabetes 62 2013 1186 1195
    • (2013) Diabetes , vol.62 , pp. 1186-1195
    • Poulsen, M.M.1
  • 33
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • S. Timmers et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans Cell Metab. 14 2011 612 622
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1
  • 34
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • P. Brasnyo et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients Br. J. Nutr. 106 2011 383 389
    • (2011) Br. J. Nutr. , vol.106 , pp. 383-389
    • Brasnyo, P.1
  • 35
    • 84865181393 scopus 로고    scopus 로고
    • Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
    • J.K. Bhatt et al. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus Nutr. Res. 32 2012 537 541
    • (2012) Nutr. Res. , vol.32 , pp. 537-541
    • Bhatt, J.K.1
  • 36
    • 80053930452 scopus 로고    scopus 로고
    • Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat
    • I. Momken et al. Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat FASEB J. 25 2011 3646 3660
    • (2011) FASEB J. , vol.25 , pp. 3646-3660
    • Momken, I.1
  • 37
    • 78649851597 scopus 로고    scopus 로고
    • Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats
    • J.R. Jackson et al. Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats Am. J. Physiol. Regulat. Integr. Comp. Physiol. 299 2010 R1572 R1581
    • (2010) Am. J. Physiol. Regulat. Integr. Comp. Physiol. , vol.299
    • Jackson, J.R.1
  • 38
    • 79960591506 scopus 로고    scopus 로고
    • Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo
    • S. Shadfar et al. Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo Nutr. Cancer 63 2011 749 762
    • (2011) Nutr. Cancer , vol.63 , pp. 749-762
    • Shadfar, S.1
  • 40
    • 80052144579 scopus 로고    scopus 로고
    • Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy
    • Y.S. Hori et al. Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy J. Pharmacol. Exp. Ther. 338 2011 784 794
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , pp. 784-794
    • Hori, Y.S.1
  • 41
    • 84855685417 scopus 로고    scopus 로고
    • Rescue of dystrophic skeletal muscle by PGC-1alpha involves a fast to slow fiber type shift in the mdx mouse
    • J.T. Selsby et al. Rescue of dystrophic skeletal muscle by PGC-1alpha involves a fast to slow fiber type shift in the mdx mouse PLoS ONE 7 2012 e30063
    • (2012) PLoS ONE , vol.7 , pp. 30063
    • Selsby, J.T.1
  • 42
    • 84872610324 scopus 로고    scopus 로고
    • Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of duchenne muscular dystrophy
    • B.S. Gordon et al. Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of duchenne muscular dystrophy Clin. Nutr. 32 2013 104 111
    • (2013) Clin. Nutr. , vol.32 , pp. 104-111
    • Gordon, B.S.1
  • 43
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    • J. Lin et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres Nature 418 2002 797 801
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1
  • 44
    • 83455223600 scopus 로고    scopus 로고
    • Remodeling of calcium handling in skeletal muscle through PGC-1alpha: Impact on force, fatigability, and fiber type
    • S. Summermatter et al. Remodeling of calcium handling in skeletal muscle through PGC-1alpha: impact on force, fatigability, and fiber type Am. J. Physiol. Cell. Physiol. 302 2012 C88 C99
    • (2012) Am. J. Physiol. Cell. Physiol. , vol.302
    • Summermatter, S.1
  • 47
    • 37549025047 scopus 로고    scopus 로고
    • A role for the transcriptional coactivator PGC-1alpha in muscle refueling
    • A.R. Wende et al. A role for the transcriptional coactivator PGC-1alpha in muscle refueling J. Biol. Chem. 282 2007 36642 36651
    • (2007) J. Biol. Chem. , vol.282 , pp. 36642-36651
    • Wende, A.R.1
  • 48
    • 45149108625 scopus 로고    scopus 로고
    • Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake
    • J.A. Calvo et al. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake J. Appl. Physiol. 104 2008 1304 1312
    • (2008) J. Appl. Physiol. , vol.104 , pp. 1304-1312
    • Calvo, J.A.1
  • 51
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • P. Bostrom et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 2012 463 468
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1
  • 52
    • 58149401189 scopus 로고    scopus 로고
    • Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    • C.S. Choi et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism Proc. Natl. Acad. Sci. U. S. A. 105 2008 19926 19931
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 19926-19931
    • Choi, C.S.1
  • 53
    • 84872050740 scopus 로고    scopus 로고
    • PGC-1alpha improves glucose homeostasis in skeletal muscle in an activity-dependent manner
    • S. Summermatter et al. PGC-1alpha improves glucose homeostasis in skeletal muscle in an activity-dependent manner Diabetes 62 2013 85 95
    • (2013) Diabetes , vol.62 , pp. 85-95
    • Summermatter, S.1
  • 54
    • 79955410387 scopus 로고    scopus 로고
    • Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity
    • S. Summermatter et al. Coordinated balancing of muscle oxidative metabolism through PGC-1alpha increases metabolic flexibility and preserves insulin sensitivity Biochem. Biophys. Res. Commun. 408 2011 180 185
    • (2011) Biochem. Biophys. Res. Commun. , vol.408 , pp. 180-185
    • Summermatter, S.1
  • 55
    • 77958453583 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway
    • S. Summermatter et al. Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway J. Biol. Chem. 285 2010 32793 32800
    • (2010) J. Biol. Chem. , vol.285 , pp. 32793-32800
    • Summermatter, S.1
  • 56
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
    • T. Wenz et al. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging Proc. Natl. Acad. Sci. U. S. A. 106 2009 20405 20410
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 20405-20410
    • Wenz, T.1
  • 57
    • 84873880480 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor gamma coactivator 1alpha/beta (PGC-1) coactivators repress the transcriptional activity of NF-kappaB in skeletal muscle cells
    • P.S. Eisele et al. The peroxisome proliferator-activated receptor gamma coactivator 1alpha/beta (PGC-1) coactivators repress the transcriptional activity of NF-kappaB in skeletal muscle cells J. Biol. Chem. 288 2013 2246 2260
    • (2013) J. Biol. Chem. , vol.288 , pp. 2246-2260
    • Eisele, P.S.1
  • 58
    • 84863268283 scopus 로고    scopus 로고
    • Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia
    • X. Wang et al. Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia PLoS ONE 7 2012 e33426
    • (2012) PLoS ONE , vol.7 , pp. 33426
    • Wang, X.1
  • 59
    • 84879418084 scopus 로고    scopus 로고
    • Rescue of dystrophic skeletal muscle by PGC-1alpha involves restored expression of dystrophin associated protein complex components and satellite cell signaling
    • K. Hollinger et al. Rescue of dystrophic skeletal muscle by PGC-1alpha involves restored expression of dystrophin associated protein complex components and satellite cell signaling Am. J. Physiol. Regul. Integr. Comp. Physiol. 305 2013 R13 R23
    • (2013) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.305
    • Hollinger, K.1
  • 60
    • 84860458565 scopus 로고    scopus 로고
    • Elevated PGC-1alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS
    • S. Da Cruz et al. Elevated PGC-1alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS Cell Metab. 15 2012 778 786
    • (2012) Cell Metab. , vol.15 , pp. 778-786
    • Da Cruz, S.1
  • 61
    • 65649085174 scopus 로고    scopus 로고
    • Exercise: It's the real thing!
    • J.A. Hawley, and J.O. Holloszy Exercise: it's the real thing! Nutr. Rev. 67 2009 172 178
    • (2009) Nutr. Rev. , vol.67 , pp. 172-178
    • Hawley, J.A.1    Holloszy, J.O.2
  • 62
    • 71249100778 scopus 로고    scopus 로고
    • Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery
    • F.W. Booth, and M.J. Laye Lack of adequate appreciation of physical exercise's complexities can pre-empt appropriate design and interpretation in scientific discovery J. Physiol. 587 2009 5527 5540
    • (2009) J. Physiol. , vol.587 , pp. 5527-5540
    • Booth, F.W.1    Laye, M.J.2
  • 63
    • 79961092644 scopus 로고    scopus 로고
    • Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice
    • J.R. Jackson et al. Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice J. Gerontol. A 66 2011 751 764
    • (2011) J. Gerontol. A , vol.66 , pp. 751-764
    • Jackson, J.R.1
  • 64
    • 84878162702 scopus 로고    scopus 로고
    • Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
    • S. Summermatter et al. Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A Proc. Natl. Acad. Sci. U. S. A. 110 2013 8738 8743
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 8738-8743
    • Summermatter, S.1


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