Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the phosphatidylinositol 3-kinase/protein kinase B pathway

Toxicology Letters

Volumn 229, Issue 1, 2014, Pages 265-272

  An, Jing ^a   Wang, Xiu ^a   Guo, Panpan ^a   Zhong, Yufang ^a   Zhang, Xinyu ^a   Yu, Zhiqiang ^b  

^a SHANGHAI UNIVERSITY   (China)

^b GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

Author keywords

Chemoresistance; Cisplatin; HBCD; NF B; P53; PCBs; PI3K Akt pathway

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CISPLATIN; HEXABROMOCYCLODODECANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCHLORINATED BIPHENYL; PROTEIN KINASE B; PROTEIN MDMX; PROTEIN P53;

ARTICLE; CANCER RESISTANCE; CELL SURVIVAL; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

CHEMORESISTANCE; CISPLATIN; HBCD; NF-ΚB; P53; PCBS; PI3K/AKT PATHWAY;

ALKALINE PHOSPHATASE; ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CISPLATIN; COMET ASSAY; DRUG RESISTANCE, NEOPLASM; ENVIRONMENTAL POLLUTANTS; HUMANS; HYDROCARBONS, BROMINATED; INDICATORS AND REAGENTS; LIVER NEOPLASMS, EXPERIMENTAL; NF-KAPPA B; NUCLEAR PROTEINS; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; POLYCHLORINATED BIPHENYLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84903749030     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.06.025     Document Type: Article

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