2,2′,4,4′,5,5′-Hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits β-catenin-dependent transcription in liver epithelial cells

Toxicology

Volumn 260, Issue 1-3, 2009, Pages 104-111

  Simeckova P ^a   Vondracek J ^a,b   Prochazkova J ^a,b   Kozubik A ^b   Krcmar P ^a   Machala, M ^a  

^a VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^b INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

Catenin; Adherens junctions; Canonical Wnt signaling; E cadherin; Polychlorinated biphenyls; Rat liver progenitor cells

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; AXIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; LEUPEPTIN; MESSENGER RNA; PLAKOGLOBIN; PROTEASOME; RECOMBINANT DNA; UVOMORULIN; WNT PROTEIN; 2,4,5,2',4',5'-HEXACHLOROBIPHENYL; AXIN PROTEIN; CADHERIN; CYSTEINE PROTEINASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; POLYCHLORINATED BIPHENYL; REPRESSOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; GENE EXPRESSION; LIVER CELL; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; LIVER; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

RATTUS;

ADHERENS JUNCTIONS; ANIMALS; BETA CATENIN; BLOTTING, WESTERN; CADHERINS; CELL LINE; CYSTEINE PROTEINASE INHIBITORS; EPITHELIAL CELLS; GAMMA CATENIN; GLYCOGEN SYNTHASE KINASE 3; LEUPEPTINS; LIVER; LYSOSOMES; PHOSPHORYLATION; POLYCHLORINATED BIPHENYLS; RATS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS; TRANSCRIPTION, GENETIC;

EID: 67349237189     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.03.014     Document Type: Article

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