Environmental exposures and gene regulation in disease etiology

Environmental Health Perspectives

Volumn 115, Issue 9, 2007, Pages 1264-1270

  Edwards, Thea M ^a,b   Myers, John Peterson ^b  

^a University of Florida ^*  (United States)

^b Environmental Health Sciences   (United States)

Author keywords

Chemicals; Disease risk; DNA methylation; Drug resistance; Endoctrine disruption; Environmental; Fetal origins of adult disease; Gene expression; Gene regulation; Susceptibility

Indexed keywords

ANTIBIOTIC AGENT; CADMIUM; ESTROGEN DERIVATIVE; FLUOROPYRIMIDINE; FLUOROURACIL; HEAVY METAL; HISTONE; INDUSTRIAL CHEMICAL; PESTICIDE; VITAMIN D;

ADULT DISEASE; AGING; AIR POLLUTANT; ALLERGY; ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ANTIBIOTIC RESISTANCE; CANCER RESISTANCE; CANCER RISK; CARCINOGENESIS; COLON CANCER; DEGENERATIVE DISEASE; DIABETES MELLITUS; DISEASE EXACERBATION; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; DRUG MECHANISM; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE ACTIVATION; GENE AMPLIFICATION; GENE CONTROL; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE NUMBER; GENE OVEREXPRESSION; GENE TRANSLOCATION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC DISORDER; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENITAL SYSTEM DISEASE; HUMAN; INFERTILITY; INHERITANCE; NONHODGKIN LYMPHOMA; NONHUMAN; NUTRITIONAL DEFICIENCY; OBESITY; PARKINSON DISEASE; PATHOPHYSIOLOGY; PHARMACOGENETICS; POLLUTION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PUBLICATION; REGULATORY MECHANISM; RESPIRATORY TRACT DISEASE; REVIEW; RISK ASSESSMENT; RISK FACTOR; RNA STABILITY;

ANIMALS; DIABETES MELLITUS; DRUG RESISTANCE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERSENSITIVITY; LYMPHOMA, NON-HODGKIN; NEOPLASMS; PARKINSON DISEASE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTION; RESPIRATORY TRACT DISEASES;

EID: 34748826738     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9951     Document Type: Review

References (109)

1. Akesson AA, Lundh T, Vahter M, Bjellerup P, Lidfeldt J, Nerbrand C, et al. 2005. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 113:1627-1631.
2. Anway MD, Cupp AS, Uzumcu M, Skinner MK. 2005. Epigenetic transgenerational actions of endocrine disruptors and mate fertility. Science 308(5727):1466-1469.
3. Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VMY, et al. 1998. Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152(4):879-884.
4. Baccarelli A, Hirt C, Pesatori AC, Consonni D, Patterson DG, Bertazzi PA, Dolken G, Landi MT. 2006. t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, Italy. Carcinogenesis 27(10):2001-2007.
5. Bao BY, Yeh SD, Lee YF. 2006. 1 α,25-dihydroxyvitamin D-3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 27(1):32-42.
6. Benjamin RC, Gill DM. 1980. Poly(ADP-ribose) synthesis in vitro programmed by damaged DNA - a comparison of DNA molecules containing different types of strand breaks. J Biol Chem 255(21):502-508.
7. Bestor TH. 2000. The DNA methyltransferases of mammals. Hum Mol Genet 9(16):2395-2402.
8. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3(12):1301-1306.
9. Boland S, Bonvallot V, Fournier T, Baeza-Squiban A, Aubier M, Marano F. 2000. Mechanisms of GM-CSF increase by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 278(1):L25-L32.
10. Bolognesi C. 2003. Genotoxicity of pesticides: a review of human biomonitoring studies. Mutat Res 543(3):251-272.
11. Brookman JJ, Toosy AT, Shashidhara LS, White RAH. 1992. The 412 retrotransposon and the development of gonadal mesoderm in Drosophila. Development 116(4):1185-1192.
12. Brown AWA. 1986. Insecticide resistance in mosquitoes - a pragmatic review. J Am Mosq Control Assoc 2(2):123-140.
13. Cairns J, Foster PL. 1991. Adaptive reversion of a frameshift mutation in Escherichia coli. Genetics 128(4):695-701.
14. Centers for Disease Control and Prevention. 2005. Third National Report on Human Exposure to Environmental Chemicals. National Center for Environmental Health Publ no 05-0570. Atlanta:Centers for Disease Control and Prevention.
15. Cervantes-Laurean D, Jacobson EL, Jacobson MK. 1996. Glycation and glycoxidation of histones by ADP-ribose. J Biol Chem 271(18):10461-10469.
16. Cervoni N, Szyf M. 2001. Demethylase activity is directed by histone acetylation. J Biol Chem 276(44):40778-40787.
17. Cheng RYS, Alvord WG, Powell D, Kasprzak KS, Anderson LM. 2002. Increased serum corticosterone and glucose in offspring of chromium(III)-treated male mice. Environ Health Perspect 110:801-804.
18. Cheng RYS, Hockman T, Crawford E, Anderson LM, Shiao YH. 2004. Epigenetic and gene expression changes related to transgenerational carcinogenesis. Mol Carcinog 40(1): 1-11.
19. Copur S, Aiba K, Drake JC, Allegra CJ, Chu E. 1995. Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil. Biochem Pharmacol 49(10): 1419-1426.
20. Day JK, Bauer AM, desBordes C, Zhuang Y, Kim BE, Newton LG, et al. 2002. Genistein alters methylation patterns in mice. J Nutr 132(8):2419S-2423S.
21. De Petro G, Tavian D, Copeta A, Portolani N, Giulini SM, Barlati S. 1998. Expression of urokinase-type plasminogen activator (uPA), uPA receptor, and tissue-type PA messenger RNAs in human hepatocellular carcinoma. Cancer Res 58(10): 2234-2239.
22. Diefenbach J, Bürkle A. 2005. Introduction to poly(ADP-ribose) metabolism. Cell Mol Life Sci 62(7-8):721-730.
23. Doherty AS, Mann MRW, Tremblay KD, Bartolomei MS, Schultz RM. 2000. Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod 62(6):1526-1535.
24. Dolinoy DC, Weidman JR, Waterland RA, Jirtle RL. 2006. Maternal genistein alters coat color and protects A(vy) mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 114:567-572.
25. Donaldson K, Stone V, Borm PJA, Jimenez LA, Gilmour PS, Schins RPF, et al. 2003. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med 34(11):1369-1382.
26. Ehrlich M. 2002. DNA methylation in cancer: too much, but also too little. Oncogene 21(35):5400-5413.
27. El-Sawy M, Kale SP, Dugan C, Nguyen TQ, Belancio V, Bruch H, et al. 2005. Nickel stimulates L1 retrotransposition by a post-transcriptional mechanism. J Mol Biol 354(2):246-257.
28. Etoh T, Kanai Y, Ushijima S, Nakagawa T, Nakanishi Y, Sasako M, et al. 2004. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 164(2):689-699.
29. Fleming L, Mann JB, Bean J, Briggle T, Sanchezramos JR. 1994. Parkinson's disease and brain levels of organochlorine pesticides. Ann Neurol 36(1):100-103.
30. Foster PL. 1994. Population dynamics of a lac(-) strain of Escherichia coli during selection for lactose utilization. Genetics 138(2):253-261.
31. Gaido KW, Maness SC. 1995. Posttranscriptional stabilization of urokinase plasminogen-activator messenger RNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a human keratinocyte cell line. Toxicol Appl Pharmacol 133(1):34-42.
32. Gao ZH, Suppola S, Liu J, Heikkila P, Janne J, Voutilainen R. 2002. Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors. J Clin Endocrinol Metab 87(3):1170-1176.
33. Gilmour PS, Rahman I, Donaldson K, MacNee W. 2003. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol Lung Cell Mol Physiol 284(3):L533-L540.
34. Gilmour PS, Rahman I, Hayashi S, Hogg JC, Donaldson K, MacNee W. 2001. Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8. Am J Physiol Lung Cell Mol Physiol 281(3):L598-L606.
35. Guerrero-Bosagna C, Sabat P, Valladares L. 2005. Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos? Evol Dev 7(4):341-350.
36. Gugliucci A, Bendayan M. 1995. Histones from diabetic rats contain increased levels of advanced glycation end products. Biochem Biophys Res Commun 212(1):56-62.
37. Hajkova P, Erhardt S, Lane N, Haaf T, El-Maarri O, Reik W, et al. 2002. Epigenetic reprogramming in mouse primordial germ cells. Mech Dev 117(1-2):15-23.
38. Hastings PJ, Slack A, Petrosino JF, Rosenberg SM. 2004. Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms. PLOS Biol 2(12):2220-2233.
39. Hayes JD, Pulford DJ. 1995. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30(6):445-600.
40. Henry WM, Knapp KT. 1980. Compound forms of fossil fuel fly-ash emissions. Environ Sci Technol 14(4):450-456.
41. Hersh MN, Ponder RG, Hastings PJ, Rosenberg SM. 2004. Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress. Res Microbiol 155(5):352-359.
42. Jirajaroenrat K, Pongjaroenkit S, Krittanai C, Prapanthadara LA, Ketterman AJ. 2001. Heterologous expression and characterization of alternatively spliced glutathione S-transferases from a single Anopheles gene. Insect Biochem Mol Biol 31(9):867-875.
43. Jordan IK, Rogozin IB, Glazko GV, Koonin EV. 2003. Origin of a Gene-by-environment interactions and disease substantial fraction of human regulatory sequences from transposable elements. Trends Genet 19(2):68-72.
44. Kim HT, Choi BH, Niikawa N, Lee TS, Chang SI. 1998. Frequent loss of imprinting of the H19 and IGF-II genes in ovarian tumors. Am J Med Genet 80(4):391-395.
45. Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, Isola J, et al. 1997. Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res 57(2):314-319.
46. INK4A methylation in head and neck squamous cell carcinoma. Int J Cancer 119(7):1553-1557.
47. Kurata Y, Katsuta O, Doi T, Kawasuso T, Hiratsuka H, Tsuchitani M, et al. 2003. Chronic cadmium treatment induces islet B cell injury in ovariectomized Cynomolgus monkeys. Jpn J Vet Res 50(4):175-183.
48. 2+. Immunology 109(1):76-86.
49. Lee MH, Kim E, Kim TS. 2004. Exposure to 4-tert-octylphenol, an environmentally persistent alkylphenol, enhances interleukin- 4 production in T cells via NF-AT activation. Toxicol Appl Pharmacol 197(1):19-28.
50. Li SF, Hursting SD, Davis BJ, McLachlan JA, Barrett JC. 2003. Environmental exposure, DNA methylation, and gene regulation - lessons from diethylstilbesterol-induced cancers. In: Epigenetics in Cancer Prevention: Early Detection and Risk Assessment. New York:New York Academy of Sciences, 161-169.
51. Li SF, Washburn KA, Moore R, Uno T, Teng C, Newbold RR, et al. 1997. Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus. Cancer Res 57(19):4356-4359.
52. Lilienthal H, Fastabend A, Hany J, Kaya H, Roth-Harer A, Dunemann L, et al. 2000. Reduced levels of 1,25-dihydroxy-vitamin D-3 in rat dams and offspring after exposure to a reconstituted PCB mixture. Toxicol Sci 57(2):292-301.
53. Lu KP, Hallberg LH, Tomlinson J, Ramos KS. 2000. Benzo(a)pyrene activates L1Md retrotransposon and inhibits DNA repair in vascular smooth muscle cells. Mutat Res 454(1-2):35-44.
54. Lu KP, Ramos KS. 1998. Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis. Biochem Biophys Res Commun 253(3):828-833.
55. Marano F, Boland S, Bonvallot V, Baulig A, Baeza-Squiban A. 2002. Human airway epithelial cells in culture for studying the molecular mechanisms of the inflammatory response triggered by diesel exhaust particles. Cell Biol Toxicol 18(5):315-320.
56. Meredith GE, Halliday GM, Totterdell S. 2004. A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formation. Parkinsonism Relat Disord 10(4):191-202.
57. Minegishi T, Hirakawa T, Abe K, Kishi H, Miyamoto K. 2003. Effect of IGF-1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the expression of LH receptors during cell differentiation in cultured granulosa cells. Mol Cell Endocrinol 202(1-2): 123-131.
58. Moore DJ, West AB, Dawson VL, Dawson TM. 2005. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 28:57-87.
59. Morales JF, Snow ET, Murnane JP. 2002. Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis 17(3):193-200.
60. Mytilineou C, McNaught KSP, Shashidharan P, Yabut J, Baptiste RJ, Parnandi A, et al. 2004. Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress. J Neural Transm 111(10-11):1237-1251.
61. Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. 1998. Increased tumors but uncompromised fertility in the female descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 19(9):1655-1663.
62. Newbold RR, Hanson RB, Jefferson WN, Bullock BC, Haseman J, McLachlan JA. 2000. Proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol. Carcinogenesis 21(7):1355-1363.
63. Palus J, Rydzynski K, Dziubaltowska E, Wyszynska K, Natarajan AT, Nilsson R. 2003. Genotoxic effects of occupational exposure to lead and cadmium. Mutat Res Genet Toxicol Environ. Mutagen. 540(1):19-28.
64. Pentecost BT, Teng CT. 1987. Lactotransferrin is the major estrogen inducible protein of mouse uterine secretions. J Biol Chem 262(21):10134-10139.
65. Pogribny IP, James SJ, Jernigan S, Pogribna M. 2004. Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues. Mutat Res 548: 53-9.
66. Prody CA, Dreyfus P, Zamir R, Zakut H, Soreq H. 1989. De novo amplification within a silent human cholinesterase gene in a family subjected to prolonged exposure to organophosphorous insecticides. Proc Natl Acad Sci USA 86(2):690-694.
67. Reik W, Dean W, Walter J. 2001. Epigenetic reprogramming in mammalian development. Science 293(5532):1089-1093.
68. Reik W, Walter J. 2001. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2(1):21-32.
69. Richardson B. 2003. Impact of aging on DNA methylation. Ageing Res Rev 2(3):245-261.
70. Ritchie JM, Vial SL, Fuortes LJ, Guo HJ, Reedy VE, Smith EM. 2003. Organochlorines and risk of prostate cancer. J Occup Environ Med 45(7):692-702.
71. Ritchie JM, Vial SL, Fuortes LJ, Robertson LW, Guo HJ, Reedy VE, et al. 2005. Comparison of proposed frameworks for grouping polychlorinated biphenyl congener data applied to a case-control pilot study of prostate cancer. Environ Res 98(1):104-113.
72. Roling JA, Bain LJ, Baldwin WS. 2004. Differential gene expression in mummichogs (Fundulus heteroclitus) following treatment with pyrene: comparison to a creosote contaminated site. Mar Environ Res 57(5):377-395.
73. Rouleau M, Aubin RA, Poirier GG. 2004. Poly(ADP-ribosyl)ated chromatin domains: access granted. J Cell Sci 117(6):815-825.
74. Roulland S, Lebailly P, Lecluse Y, Briand M, Pottier D, Gauduchon P. 2004. Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides. Cancer Res 64(6):2264-2269.
75. Ruden DM, Xiao L, Garfinkel MD, Lu X. 2005. HSP90 and environmental impacts on epigenetic states: a model for the transgenerational effects of diethylstilbestrol on uterine development and cancer. Hum Mol Genet 14:R149-R155.
76. Ruggero D, Pandolfi PP. 2003. Does the ribosome translate cancer? Nat Rev Cancer 3(3):179-192.
77. Samet JM, Silbajoris R, Huang T, Jaspers I. 2002. Transcription factor activation following exposure of an intact lung preparation to metallic particulate matter. Environ Health Perspect 110:985-990.
78. Schiff R, Itin A, Keshet E. 1991. Transcriptional activation of mouse retrotransposons in vivo - specific expression in steroidogenic cells in response to trophic hormones. Genes Dev 5(4):521-532.
79. Schroeder JC, Olshan AF, Baric R, Dent GA, Weinberg CR, Yount B, et al. 2001. Agricultural risk factors for t(14;18) subtypes of non-Hodgkin's lymphoma. Epidemiology 12(6):701-709.
80. Schwartz GG, Il'yasova D, Ivanova A. 2003. Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III. Diabetes Care 26(2):468-470.
81. Shiao YH, Crawford EB, Anderson LM, Patel P, Ko K. 2005. Allele-specific germ cell epimutation in the spacer promoter of the 45S ribosomal RNA gene after Cr(III) exposure. Toxicol Appl Pharmacol 205(3):290-296.
82. Shimba S, Hayashi M, Sone H, Yonemoto J, Tezuka M. 2000. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces binding of a 50 kDa protein on the 3′ untranslated region of urokinase-type plasminogen activator mRNA. Biochem Biophys Res Commun 272(2):441-448.
83. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, et al. 2003. α-Synuclein locus triplication causes Parkinson's disease. Science 302(5646):841-841.
84. Sinibaldi-Vallebona P, Lavia P, Garaci E, Spadafora C. 2006. A role for endogenous reverse transcriptase in tumorigenesis and as a target in differentiating cancer therapy. Genes Chromosomes Cancer 45(1):1-10.
85. Smith FM, Garfield AS, Ward A. 2006. Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 113(1-4):279-291.
86. Smith MT, McHale CM, Wiemels JL, Zhang LP, Wiencke JK, Zheng SC, et al. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245.
87. Stribinskis V, Ramos KS. 2006. Activation of human long interspersed nuclear element 1 retrotransposition by benzo(a)-pyrene, a ubiquitous environmental carcinogen. Cancer Res 66(5):2616-2620.
88. Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy AG. 2005. Dieldrin induces ubiquitin-proteasome dysfunction in α-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. J Pharmacol Exp Ther 315(1):69-79.
89. Surani MA. 2001. Reprogramming of genome function through epigenetic inheritance. Nature 414(6859):122-128.
90. Tam PPL, Zhou SX, Tan SS. 1994. X-Chromosome activity of the mouse primordial germ cells revealed by the expression of an X-linked LacZ transgene. Development 120(10):2925-2932.
91. Tan SS, Williams EA, Tam PPL. 1993. X-chromosome inactivation occurs at different times in different tissues of the postimplantation mouse embryo. Nature Genet 3(2):170-174.
92. Taniguchi T, Sullivan MJ, Ogawa O, Reeve AE. 1995. Epigenetic changes encompassing the Igf2/H19 locus associated with relaxation of Igf2 imprinting and silencing of H19 in Wilms tumor. Proc Natl Acad Sci USA 92(6):2159-2163.
93. Trelogan SA, Martin SL. 1995. Tightly regulated, developmentally specific expression of the first open reading frame from Line-1 during mouse embryogenesis. Proc Natl Acad Sci USA 92(5):1520-1524.
94. Tsujimoto Y, Gorham J, Cossman J, Jaffe E, Croce CM. 1985. The T(14,18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229(4720): 1390-1392.
95. Tu PH, Galvin JE, Baba M, Giasson B, Tomita T, Leight S, et al. 1998. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein. Ann Neurol 44(3):415-422.
96. Turusov VS, Trukhanova LS, Parfenov YD, Tomatis L. 1992. Occurrence of tumors in the descendants of CBA male mice prenatally treated with diethylstilbestrol. Int J Cancer 50(1): 131-135.
97. Vangurp R, Oosterhuis JW, Kalscheuer V, Mariman ECM, Looijenga LHJ. 1994. Biallelic expression of the H19 and Igf2 genes in human testicular germ cell tumors. J Natl Cancer Inst 86(14):1070-1075.
98. Verschure PJ. 2004. Positioning the genome within the nucleus. Biol Cell 96(8):569-577.
99. Virág L, Szabó C. 2002. The therapeutic potential of poly (ADP-ribose) polymerase inhibitors. Pharmacol Rev 54(3):375-429.
100. Vivacqua A, Recchia AG, Fasanella G, Gabriele S, Carpino A, Rago V, et al. 2003. The food contaminants bisphenol A and 4-nonylphenol act as agonists for estrogen receptor alpha in MCF7 breast cancer cells. Endocrine 22(3):275-284.
101. Walker BE, Haven MI. 1997. Intensity of multigenerational carcinogenesis from diethylstilbestrol in mice. Carcinogenesis 18(4):791-793.
102. Weaver ICG, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, et al. 2004. Epigenetic programming by maternal behavior. Nat Neurosci 7(8):847-854.
103. Weaver ICG, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, et al. 2005. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25(47):11045-11054.
104. Wilks A, Seldran M, Jost JP. 1984. An estrogen-dependent demethylation at the 5′ end of the chicken vitellogenin gene is independent of DNA synthesis. Nucleic Acids Res 12(2): 1163-1177.
105. Wu GY, Bazer FW, Cudd TA, Meininger CJ, Spencer TE. 2004. Maternal nutrition and fetal development. J Nutr 134(9): 2169-2172.
106. Wu Q, Ohsako S, Ishimura R, Suzuki JS, Tohyama C. 2004. Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biol Reprod 70(6):1790-1797.
107. Xu Q, Liu HQ, Zhang L, Liu NN. 2005. Resistance in the mosquito, Culex quinque-fasciatus, and possible mechanisms for resistance. Pest Manag Sci 61(11):1096-1102.
108. Yang JM, Arnush M, Chen QY, Wu XD, Pang B, Jiang XZ. 2003. Cadmium-induced damage to primary cultures of rat Leydig cells. Reprod Toxicol 17(5):553-560.
109. Yu W, Sipowicz MA, Haines DC, Birely L, Diwan BA, Riggs CW, et al. 1999. Preconception urethane or chromium(III) treatment of male mice: multiple neoplastic and non-neoplastic changes in offspring. Toxicol Appl Pharmacol 158(2):161-176.