Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells

Breast Cancer Research and Treatment

Volumn 146, Issue 1, 2014, Pages 99-108

  Katz, Tiffany A ^a,b,c   Vasilatos, Shauna N ^a,c   Harrington, Emily ^a,b,c   Oesterreich, Steffi ^a,b,c   Davidson, Nancy E ^a,b,c   Huang, Yi ^a,b,c,d  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Apoptosis; Breast cancer; Combination therapy; DNA methylation; DNMT inhibitor; LSD2

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; ESTROGEN RECEPTOR ALPHA; HISTONE DEACETYLASE; HISTONE DEMETHYLASE; LYSINE SPECIFIC DEMETHYLASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROGESTERONE RECEPTOR; RETINOIC ACID RECEPTOR BETA; SECRETED FRIZZLED RELATED PROTEIN 1; SECRETED FRIZZLED RELATED PROTEIN 2; TRANYLCYPROMINE; UNCLASSIFIED DRUG; UVOMORULIN; ANTINEOPLASTIC AGENT; DNA (CYTOSINE 5) METHYLTRANSFERASE; HISTONE; LYSINE (K)-SPECIFIC DEMETHYLASE 1B, HUMAN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BREAST CANCER CELL LINE; CANCER INHIBITION; CANCER SURVIVAL; CDH1 GENE; CELL CYCLE; CELL DEATH; COLONY FORMATION; CONTROLLED STUDY; DNA FRAGMENTATION; DNA METHYLATION; DNMT1 GENE; DNMT3L GENE; ENZYME INHIBITION; ERALPHA GENE; GENE; GENE SILENCING; HUMAN; LSD2 GENE; PR GENE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RARBETA GENE; SFRP1 GENE; SFRP2 GENE; TUMOR GROWTH; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENETICS; IC50; METABOLISM; METHYLATION; TRANSCRIPTION INITIATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE SILENCING; HISTONE DEMETHYLASES; HISTONES; HUMANS; INHIBITORY CONCENTRATION 50; METHYLATION; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; TUMOR STEM CELL ASSAY;

EID: 84903739607     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3012-9     Document Type: Article

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