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Volumn 111, Issue 26, 2014, Pages 9491-9496

Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila

Author keywords

Kohtalo; Metabolic syndrome; Myokines; Skuld

Indexed keywords

BETA CATENIN; MED12 PROTEIN; MED13 PROTEIN; MEDIATOR COMPLEX; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84903719295     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409427111     Document Type: Article
Times cited : (46)

References (50)
  • 1
    • 84864283300 scopus 로고    scopus 로고
    • Muscles, exercise and obesity: Skeletal muscle as a secretory organ
    • Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nat Rev Endocrinol 8(8):457-465.
    • (2012) Nat Rev Endocrinol , vol.8 , Issue.8 , pp. 457-465
    • Pedersen, B.K.1    Febbraio, M.A.2
  • 2
    • 33746328957 scopus 로고    scopus 로고
    • Signaling pathways in skeletal muscle remodeling
    • Bassel-Duby R, Olson EN (2006) Signaling pathways in skeletal muscle remodeling. Annu Rev Biochem 75:19-37.
    • (2006) Annu Rev Biochem , vol.75 , pp. 19-37
    • Bassel-Duby, R.1    Olson, E.N.2
  • 3
    • 84886786722 scopus 로고    scopus 로고
    • Muscle mitohormesis promotes longevity via systemic repression of insulin signaling
    • Owusu-Ansah E, Song W, Perrimon N (2013) Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell 155(3):699-712.
    • (2013) Cell , vol.155 , Issue.3 , pp. 699-712
    • Owusu-Ansah, E.1    Song, W.2    Perrimon, N.3
  • 4
    • 84860340270 scopus 로고    scopus 로고
    • A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
    • Grueter CE, et al. (2012) A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell 149(3):671-683.
    • (2012) Cell , vol.149 , Issue.3 , pp. 671-683
    • Grueter, C.E.1
  • 5
    • 0037178788 scopus 로고    scopus 로고
    • Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
    • Boube M, Joulia L, Cribbs DL, Bourbon HM (2002) Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 110(2): 143-151.
    • (2002) Cell , vol.110 , Issue.2 , pp. 143-151
    • Boube, M.1    Joulia, L.2    Cribbs, D.L.3    Bourbon, H.M.4
  • 6
    • 77954759030 scopus 로고    scopus 로고
    • The human Mediator complex: A versatile, genome-wide regulator of transcription
    • Taatjes DJ (2010) The human Mediator complex: A versatile, genome-wide regulator of transcription. Trends Biochem Sci 35(6):315-322.
    • (2010) Trends Biochem Sci , vol.35 , Issue.6 , pp. 315-322
    • Taatjes, D.J.1
  • 7
    • 23744490065 scopus 로고    scopus 로고
    • Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets
    • van de Peppel J, et al. (2005) Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets. Mol Cell 19(4):511-522.
    • (2005) Mol Cell , vol.19 , Issue.4 , pp. 511-522
    • Van De Peppel, J.1
  • 8
    • 84902179680 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 8 module expression profiling reveals requirement of Mediator subunits 12 and 13 for transcription of Serpentdependent innate immunity genes in Drosophila
    • Kuuluvainen E, et al. (2014) Cyclin-dependent kinase 8 module expression profiling reveals requirement of Mediator subunits 12 and 13 for transcription of Serpentdependent innate immunity genes in Drosophila. J Biol Chem 289(23):16252-16261.
    • (2014) J Biol Chem , vol.289 , Issue.23 , pp. 16252-16261
    • Kuuluvainen, E.1
  • 9
    • 73349130440 scopus 로고    scopus 로고
    • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
    • Pospisilik JA, et al. (2010) Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 140(1):148-160.
    • (2010) Cell , vol.140 , Issue.1 , pp. 148-160
    • Pospisilik, J.A.1
  • 10
    • 84893508942 scopus 로고    scopus 로고
    • A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity
    • Baumbach J, et al. (2014) A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Cell Metab 19(2):331-343.
    • (2014) Cell Metab , vol.19 , Issue.2 , pp. 331-343
    • Baumbach, J.1
  • 11
    • 78649701176 scopus 로고    scopus 로고
    • A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability
    • Reis T, Van Gilst MR, Hariharan IK (2010) A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. PLoS Genet 6(11):e1001206.
    • (2010) PLoS Genet , vol.6 , Issue.11
    • Reis, T.1    Van Gilst, M.R.2    Hariharan, I.K.3
  • 12
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    • Baker KD, Thummel CS (2007) Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab 6(4):257-266.
    • (2007) Cell Metab , vol.6 , Issue.4 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 13
    • 84874586591 scopus 로고    scopus 로고
    • Modeling obesity and its associated disorders in Drosophila
    • Trinh I, Boulianne GL (2013) Modeling obesity and its associated disorders in Drosophila. Physiology (Bethesda) 28(2):117-124.
    • (2013) Physiology (Bethesda) , vol.28 , Issue.2 , pp. 117-124
    • Trinh, I.1    Boulianne, G.L.2
  • 14
    • 79251646185 scopus 로고    scopus 로고
    • Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms
    • Oldham S (2011) Obesity and nutrient sensing TOR pathway in flies and vertebrates: Functional conservation of genetic mechanisms. Trends Endocrinol Metab 22(2): 45-52.
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.2 , pp. 45-52
    • Oldham, S.1
  • 15
    • 84860350761 scopus 로고    scopus 로고
    • Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction
    • Diop SB, Bodmer R (2012) Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction. J Cell Mol Med 16(5):966-971.
    • (2012) J Cell Mol Med , vol.16 , Issue.5 , pp. 966-971
    • Diop, S.B.1    Bodmer, R.2
  • 16
    • 84866978180 scopus 로고    scopus 로고
    • Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
    • Rajan A, Perrimon N (2012) Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell 151(1):123-137.
    • (2012) Cell , vol.151 , Issue.1 , pp. 123-137
    • Rajan, A.1    Perrimon, N.2
  • 17
    • 0042009474 scopus 로고    scopus 로고
    • Two subunits of the Drosophila mediator complex act together to control cell affinity
    • Janody F, Martirosyan Z, Benlali A, Treisman JE (2003) Two subunits of the Drosophila mediator complex act together to control cell affinity. Development 130(16): 3691-3701.
    • (2003) Development , vol.130 , Issue.16 , pp. 3691-3701
    • Janody, F.1    Martirosyan, Z.2    Benlali, A.3    Treisman, J.E.4
  • 18
    • 0029992508 scopus 로고    scopus 로고
    • Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo
    • Ranganayakulu G, Schulz RA, Olson EN (1996) Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo. Dev Biol 176(1): 143-148.
    • (1996) Dev Biol , vol.176 , Issue.1 , pp. 143-148
    • Ranganayakulu, G.1    Schulz, R.A.2    Olson, E.N.3
  • 19
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118(2):401-415.
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 20
    • 37749006118 scopus 로고    scopus 로고
    • Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
    • Ni JQ, et al. (2008) Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods 5(1):49-51.
    • (2008) Nat Methods , vol.5 , Issue.1 , pp. 49-51
    • Ni, J.Q.1
  • 21
    • 34447530305 scopus 로고    scopus 로고
    • A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    • Dietzl G, et al. (2007) A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448(7150):151-156.
    • (2007) Nature , vol.448 , Issue.7150 , pp. 151-156
    • Dietzl, G.1
  • 22
    • 0030273379 scopus 로고    scopus 로고
    • Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
    • Schuster CM, Davis GW, Fetter RD, Goodman CS (1996) Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17(4):641-654.
    • (1996) Neuron , vol.17 , Issue.4 , pp. 641-654
    • Schuster, C.M.1    Davis, G.W.2    Fetter, R.D.3    Goodman, C.S.4
  • 23
    • 80053970996 scopus 로고    scopus 로고
    • JAK/Stat signaling regulates heart precursor diversification in Drosophila
    • Johnson AN, Mokalled MH, Haden TN, Olson EN (2011) JAK/Stat signaling regulates heart precursor diversification in Drosophila. Development 138(21):4627-4638.
    • (2011) Development , vol.138 , Issue.21 , pp. 4627-4638
    • Johnson, A.N.1    Mokalled, M.H.2    Haden, T.N.3    Olson, E.N.4
  • 24
    • 0034967570 scopus 로고    scopus 로고
    • A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila
    • Lo PC, Frasch M (2001) A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech Dev 104(1-2):49-60.
    • (2001) Mech Dev , vol.104 , Issue.1-2 , pp. 49-60
    • Lo, P.C.1    Frasch, M.2
  • 25
    • 84871024376 scopus 로고    scopus 로고
    • Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model
    • Liu J, et al. (2012) Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model. Int J Obes (Lond) 36(12):1529-1536.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.12 , pp. 1529-1536
    • Liu, J.1
  • 26
    • 0035093107 scopus 로고    scopus 로고
    • Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development
    • Treisman J (2001) Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development. Development 128(4):603-615.
    • (2001) Development , vol.128 , Issue.4 , pp. 603-615
    • Treisman, J.1
  • 27
    • 33847228720 scopus 로고    scopus 로고
    • Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    • Loncle N, et al. (2007) Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J 26(4):1045-1054.
    • (2007) EMBO J , vol.26 , Issue.4 , pp. 1045-1054
    • Loncle, N.1
  • 28
    • 78049425280 scopus 로고    scopus 로고
    • High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    • Birse RT, et al. (2010) High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab 12(5):533-544.
    • (2010) Cell Metab , vol.12 , Issue.5 , pp. 533-544
    • Birse, R.T.1
  • 29
    • 0028108926 scopus 로고
    • Embryonic fat-cell lineage in Drosophila melanogaster
    • Hoshizaki DK, et al. (1994) Embryonic fat-cell lineage in Drosophila melanogaster. Development 120(9):2489-2499.
    • (1994) Development , vol.120 , Issue.9 , pp. 2489-2499
    • Hoshizaki, D.K.1
  • 30
    • 33645046358 scopus 로고    scopus 로고
    • Hedgehog signaling plays a conserved role in inhibiting fat formation
    • Suh JM, et al. (2006) Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab 3(1):25-34.
    • (2006) Cell Metab , vol.3 , Issue.1 , pp. 25-34
    • Suh, J.M.1
  • 31
    • 84863552454 scopus 로고    scopus 로고
    • Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1
    • Zhao X, et al. (2012) Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest 122(7):2417-2427.
    • (2012) J Clin Invest , vol.122 , Issue.7 , pp. 2417-2427
    • Zhao, X.1
  • 32
    • 0035958265 scopus 로고    scopus 로고
    • Diptericin-like protein: An immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila
    • Lee JH, et al. (2001) Diptericin-like protein: An immune response gene regulated by the anti-bacterial gene induction pathway in Drosophila. Gene 271(2):233-238.
    • (2001) Gene , vol.271 , Issue.2 , pp. 233-238
    • Lee, J.H.1
  • 33
    • 0028978407 scopus 로고
    • Race: A Drosophila homologue of the angiotensin converting enzyme
    • Tatei K, Cai H, Ip YT, Levine M (1995) Race: A Drosophila homologue of the angiotensin converting enzyme. Mech Dev 51(2-3):157-168.
    • (1995) Mech Dev , vol.51 , Issue.2-3 , pp. 157-168
    • Tatei, K.1    Cai, H.2    Ip, Y.T.3    Levine, M.4
  • 35
    • 0036584593 scopus 로고    scopus 로고
    • Genetic analysis of insulin signaling in Drosophila
    • Garofalo RS (2002) Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol Metab 13(4):156-162.
    • (2002) Trends Endocrinol Metab , vol.13 , Issue.4 , pp. 156-162
    • Garofalo, R.S.1
  • 36
    • 79951855477 scopus 로고    scopus 로고
    • Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3
    • Wright VM, Vogt KL, Smythe E, Zeidler MP (2011) Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cell Signal 23(5):920-927.
    • (2011) Cell Signal , vol.23 , Issue.5 , pp. 920-927
    • Wright, V.M.1    Vogt, K.L.2    Smythe, E.3    Zeidler, M.P.4
  • 37
    • 9444226988 scopus 로고    scopus 로고
    • Uncomplicated human obesity is associated with a specific cardiac transcriptome: Involvement of the Wnt pathway
    • Philip-Couderc P, et al. (2004) Uncomplicated human obesity is associated with a specific cardiac transcriptome: Involvement of the Wnt pathway. FASEB J 18(13): 1539-1540.
    • (2004) FASEB J , vol.18 , Issue.13 , pp. 1539-1540
    • Philip-Couderc, P.1
  • 38
    • 84864366527 scopus 로고    scopus 로고
    • The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model
    • Zhou D, Strakovsky RS, Zhang X, Pan YX (2012) The skeletal muscle Wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model. Obesity (Silver Spring) 20(8):1577-1584.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.8 , pp. 1577-1584
    • Zhou, D.1    Strakovsky, R.S.2    Zhang, X.3    Pan, Y.X.4
  • 39
    • 0028839922 scopus 로고
    • Wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
    • Baylies MK, Martinez Arias A, Bate M (1995) wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis. Development 121(11):3829-3837.
    • (1995) Development , vol.121 , Issue.11 , pp. 3829-3837
    • Baylies, M.K.1    Martinez Arias, A.2    Bate, M.3
  • 40
    • 44349194208 scopus 로고    scopus 로고
    • Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
    • Carrera I, Janody F, Leeds N, Duveau F, Treisman JE (2008) Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13. Proc Natl Acad Sci USA 105(18):6644-6649.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.18 , pp. 6644-6649
    • Carrera, I.1    Janody, F.2    Leeds, N.3    Duveau, F.4    Treisman, J.E.5
  • 41
    • 77955749352 scopus 로고    scopus 로고
    • Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling
    • Rocha PP, Scholze M, Bleiss W, Schrewe H (2010) Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137(16): 2723-2731.
    • (2010) Development , vol.137 , Issue.16 , pp. 2723-2731
    • Rocha, P.P.1    Scholze, M.2    Bleiss, W.3    Schrewe, H.4
  • 42
    • 0034637103 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by Wnt signaling
    • Ross SE, et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289(5481): 950-953.
    • (2000) Science , vol.289 , Issue.5481 , pp. 950-953
    • Ross, S.E.1
  • 43
    • 33847048182 scopus 로고    scopus 로고
    • Wnt10b inhibits obesity in ob/ob and agouti mice
    • Wright WS, et al. (2007) Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes 56(2):295-303.
    • (2007) Diabetes , vol.56 , Issue.2 , pp. 295-303
    • Wright, W.S.1
  • 44
    • 4143115909 scopus 로고    scopus 로고
    • Wnt10b inhibits development of white and brown adipose tissues
    • Longo KA, et al. (2004) Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 279(34):35503-35509.
    • (2004) J Biol Chem , vol.279 , Issue.34 , pp. 35503-35509
    • Longo, K.A.1
  • 45
    • 84859458177 scopus 로고    scopus 로고
    • Wnt signaling activation in adipose progenitors promotes insulinindependent muscle glucose uptake
    • Zeve D, et al. (2012) Wnt signaling activation in adipose progenitors promotes insulinindependent muscle glucose uptake. Cell Metab 15(4):492-504.
    • (2012) Cell Metab , vol.15 , Issue.4 , pp. 492-504
    • Zeve, D.1
  • 46
    • 84888269219 scopus 로고    scopus 로고
    • Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice
    • Benzler J, et al. (2013) Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice. Endocrinology 154(12):4737-4745.
    • (2013) Endocrinology , vol.154 , Issue.12 , pp. 4737-4745
    • Benzler, J.1
  • 47
    • 18344378499 scopus 로고    scopus 로고
    • Lipoprotein particles are required for Hedgehog and Wingless signalling
    • Panáková D, Sprong H, Marois E, Thiele C, Eaton S (2005) Lipoprotein particles are required for Hedgehog and Wingless signalling. Nature 435(7038):58-65.
    • (2005) Nature , vol.435 , Issue.7038 , pp. 58-65
    • Panáková, D.1    Sprong, H.2    Marois, E.3    Thiele, C.4    Eaton, S.5
  • 48
    • 84855998350 scopus 로고    scopus 로고
    • Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility
    • Mulligan KA, et al. (2012) Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Proc Natl Acad Sci USA 109(2):370-377.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.2 , pp. 370-377
    • Mulligan, K.A.1
  • 49
    • 84859842928 scopus 로고    scopus 로고
    • Premature myocardial infarction is associated with low serum levels of Wnt-1
    • Goliasch G, et al. (2012) Premature myocardial infarction is associated with low serum levels of Wnt-1. Atherosclerosis 222(1):251-256.
    • (2012) Atherosclerosis , vol.222 , Issue.1 , pp. 251-256
    • Goliasch, G.1
  • 50
    • 84881587073 scopus 로고    scopus 로고
    • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi
    • Johnson AN, Mokalled MH, Valera JM, Poss KD, Olson EN (2013) Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. Development 140(17):3645-3656.
    • (2013) Development , vol.140 , Issue.17 , pp. 3645-3656
    • Johnson, A.N.1    Mokalled, M.H.2    Valera, J.M.3    Poss, K.D.4    Olson, E.N.5


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