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Volumn 154, Issue 12, 2013, Pages 4737-4745

Hypothalamic WNT signalling is impaired during obesity and reinstated by leptin treatment in male mice

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; CYCLIN D1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; NEUROPEPTIDE Y; WNT PROTEIN; ANDROGEN RECEPTOR; CHROMATIN; LEPTIN; TESTOSTERONE;

EID: 84888269219     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1746     Document Type: Article
Times cited : (47)

References (39)
  • 1
    • 66149131064 scopus 로고    scopus 로고
    • Diabetes in Asia: Epidemiology, risk factors, and pathophysiology
    • Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009;301:2129-2140.
    • (2009) JAMA , vol.301 , pp. 2129-2140
    • Chan, J.C.1    Malik, V.2    Jia, W.3
  • 2
    • 0025612094 scopus 로고
    • Localization of insulin receptor mRNA in rat brain by in situ hybridization
    • Marks JL, Porte D Jr, Stahl WL, Baskin DG. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology. 1990;127:3234-3236.
    • (1990) Endocrinology , vol.127 , pp. 3234-3236
    • Marks, J.L.1    Porte Jr., D.2    Stahl, W.L.3    Baskin, D.G.4
  • 3
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Brüning JC, Gautam D, Burks DJ, et al. Role of brain insulin receptor in control of body weight and reproduction. Science. 2000;289:2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Brüning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 4
    • 0031128225 scopus 로고    scopus 로고
    • WNTs modulate cell fate and behavior during vertebrate development
    • Moon RT, Brown JD, Torres M. WNTs modulate cell fate and behavior during vertebrate development. Trends Genet. 1997;13:157-162.
    • (1997) Trends Genet , vol.13 , pp. 157-162
    • Moon, R.T.1    Brown, J.D.2    Torres, M.3
  • 5
    • 0034053069 scopus 로고    scopus 로고
    • Wnt signaling in oncogenesis and embryogenesis - A look outside the nucleus
    • Peifer M, Polakis P. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science. 2000;287:1606-1609.
    • (2000) Science , vol.287 , pp. 1606-1609
    • Peifer, M.1    Polakis, P.2
  • 6
    • 33746075560 scopus 로고    scopus 로고
    • TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program
    • Florez JC, Jablonski KA, Bayley N, et al. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med. 2006;355:241-250.
    • (2006) N Engl J Med , vol.355 , pp. 241-250
    • Florez, J.C.1    Jablonski, K.A.2    Bayley, N.3
  • 7
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006;38:320-323.
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 8
    • 33645717329 scopus 로고    scopus 로고
    • Transcription factor 7-like 2 (TCFL2)-a novel factor involved in pathogenesis of type 2 diabetes
    • Comment on: Grant et al., Nat Genet. 2006
    • Kiessling A, Ehrhart-Bornstein M. Transcription factor 7-like 2 (TCFL2)-a novel factor involved in pathogenesis of type 2 diabetes. Comment on: Grant et al., Nat Genet. 2006. Horm Metab Res. 2006;38:137-138.
    • (2006) Horm Metab Res , vol.38 , pp. 137-138
    • Kiessling, A.1    Ehrhart-Bornstein, M.2
  • 9
    • 58149277106 scopus 로고    scopus 로고
    • Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines
    • Anagnostou SH, Shepherd PR. Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines. Biochem J. 2008;416:211-218.
    • (2008) Biochem J , vol.416 , pp. 211-218
    • Anagnostou, S.H.1    Shepherd, P.R.2
  • 10
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: Components, mechanisms, and disases
    • MacDonald BT, Tamai K, He X. Wnt/β-catenin signaling: components, mechanisms, and disases. Dev Cell. 2009;17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 11
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378:785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 12
    • 0027960448 scopus 로고
    • Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation
    • Stambolic V, Woodgett JR. Mitogen inactivation of glycogen synthase kinase-3β in intact cells via serine 9 phosphorylation. Biochem J. 1994;303(Pt 3):701-704.
    • (1994) Biochem J , vol.303 , Issue.PART 3 , pp. 701-704
    • Stambolic, V.1    Woodgett, J.R.2
  • 13
    • 0027515127 scopus 로고
    • Inactivation of glycogen synthase kinase-3β by phosphorylation: New kinase connections in insulin and growth-factor signalling
    • Sutherland C, Leighton IA, Cohen P. Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J. 1993;296(Pt 1):15-19.
    • (1993) Biochem J , vol.296 , Issue.PART 1 , pp. 15-19
    • Sutherland, C.1    Leighton, I.A.2    Cohen, P.3
  • 14
    • 0036789185 scopus 로고    scopus 로고
    • Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats
    • Cline GW, Johnson K, Regittnig W, et al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002;51:2903-2910.
    • (2002) Diabetes , vol.51 , pp. 2903-2910
    • Cline, G.W.1    Johnson, K.2    Regittnig, W.3
  • 15
    • 29244456731 scopus 로고    scopus 로고
    • Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: Molecular characterization in liver and muscle
    • Kaidanovich-Beilin O, Eldar-Finkelman H. Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. J Pharmacol Exp Ther. 2006;316:17-24.
    • (2006) J Pharmacol Exp Ther , vol.316 , pp. 17-24
    • Kaidanovich-Beilin, O.1    Eldar-Finkelman, H.2
  • 16
    • 84866411443 scopus 로고    scopus 로고
    • Hypothalamic glycogen-synthase-kinase 3β has a central role in the regulation of food intake and glucose metabolism
    • Benzler J, Ganjam GK, Kruger M, et al. Hypothalamic glycogen-synthase- kinase 3β has a central role in the regulation of food intake and glucose metabolism. Biochem J. 2012;447:175-184.
    • (2012) Biochem J , vol.447 , pp. 175-184
    • Benzler, J.1    Ganjam, G.K.2    Kruger, M.3
  • 17
    • 78649753017 scopus 로고    scopus 로고
    • Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity
    • Koch C, Augustine RA, Steger J, et al. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. J Neurosci. 2010;30:16180-16187.
    • (2010) J Neurosci , vol.30 , pp. 16180-16187
    • Koch, C.1    Augustine, R.A.2    Steger, J.3
  • 18
    • 0034807522 scopus 로고    scopus 로고
    • Seasonally inappropriate body weight induced by food restriction: Effect on hypothalamic gene expression in male Siberian hamsters
    • Mercer JG, Moar KM, Logie TJ, Findlay PA, Adam CL, Morgan PJ. Seasonally inappropriate body weight induced by food restriction: effect on hypothalamic gene expression in male Siberian hamsters. Endocrinology. 2001;142:4173-4181.
    • (2001) Endocrinology , vol.142 , pp. 4173-4181
    • Mercer, J.G.1    Moar, K.M.2    Logie, T.J.3    Findlay, P.A.4    Adam, C.L.5    Morgan, P.J.6
  • 20
    • 77954109387 scopus 로고    scopus 로고
    • Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus
    • Tups A, Anderson GM, Rizwan M, et al. Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. J Neuroendocrinol. 2010;22:534-542.
    • (2010) J Neuroendocrinol , vol.22 , pp. 534-542
    • Tups, A.1    Anderson, G.M.2    Rizwan, M.3
  • 21
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai K, Semenov M, Kato Y, et al. LDL-receptor-related proteins in Wnt signal transduction. Nature. 2000;407:530-535.
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1    Semenov, M.2    Kato, Y.3
  • 24
    • 4644227229 scopus 로고    scopus 로고
    • Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin
    • van den Hoek AM, Voshol PJ, Karnekamp BN, et al. Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin. Diabetes. 2004;53:2529-2534.
    • (2004) Diabetes , vol.53 , pp. 2529-2534
    • Van Den Hoek, A.M.1    Voshol, P.J.2    Karnekamp, B.N.3
  • 25
    • 41949142202 scopus 로고    scopus 로고
    • Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
    • Cerpa W, Godoy JA, Alfaro I, et al. Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. J Biol Chem. 2008;283:5918-5927.
    • (2008) J Biol Chem , vol.283 , pp. 5918-5927
    • Cerpa, W.1    Godoy, J.A.2    Alfaro, I.3
  • 26
    • 3242681470 scopus 로고    scopus 로고
    • Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: Functional implications of Wnt/β-catenin activity in kidney epithelial cells
    • Lyons JP, Mueller UW, Ji H, et al. Wnt-4 activates the canonical β-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/β-catenin activity in kidney epithelial cells. Exp Cell Res. 2004;298:369-387.
    • (2004) Exp Cell Res , vol.298 , pp. 369-387
    • Lyons, J.P.1    Mueller, U.W.2    Ji, H.3
  • 27
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho EH, Zhang T, Domon C, Joo CK, Freund JN, Costantini F. Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol. 2002;22:1172-1183.
    • (2002) Mol Cell Biol , vol.22 , pp. 1172-1183
    • Jho, E.H.1    Zhang, T.2    Domon, C.3    Joo, C.K.4    Freund, J.N.5    Costantini, F.6
  • 28
    • 0033119801 scopus 로고    scopus 로고
    • β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999;398:422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 29
    • 77954269929 scopus 로고    scopus 로고
    • Insulin resistance induced by uncontrolled diabetes is mediated by leptin deficiency
    • German JP, Wisse BE, Thaler JP, et al. Insulin resistance induced by uncontrolled diabetes is mediated by leptin deficiency. Diabetes. 2010;59:1626-1634.
    • (2010) Diabetes , vol.59 , pp. 1626-1634
    • German, J.P.1    Wisse, B.E.2    Thaler, J.P.3
  • 30
    • 73049107663 scopus 로고    scopus 로고
    • Antidiabetic effects of IGFBP2, a leptin-regulated gene
    • Hedbacker K, Birsoy K, Wysocki RW, et al. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab. 2010;11:11-22.
    • (2010) Cell Metab , vol.11 , pp. 11-22
    • Hedbacker, K.1    Birsoy, K.2    Wysocki, R.W.3
  • 31
    • 84871759199 scopus 로고    scopus 로고
    • Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways
    • Li Z, Shen J,Wu WK, et al. Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways. PLoS One. 2012;7:e53176.
    • (2012) PLoS One , vol.7
    • Li, Z.1    Shen, J.2    Wu, W.K.3
  • 32
    • 33744948142 scopus 로고    scopus 로고
    • Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3β
    • Valerio A, Ghisi V, Dossena M, et al. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3β. J Biol Chem. 2006;281:12950-12958.
    • (2006) J Biol Chem , vol.281 , pp. 12950-12958
    • Valerio, A.1    Ghisi, V.2    Dossena, M.3
  • 33
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci. 2002;5:566-572.
    • (2002) Nat Neurosci , vol.5 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 34
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med. 2002;8:1376-1382.
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 35
    • 33645071314 scopus 로고    scopus 로고
    • Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes
    • Gelling RW, Morton GJ, Morrison CD, et al. Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes. Cell Metab. 2006;3:67-73.
    • (2006) Cell Metab , vol.3 , pp. 67-73
    • Gelling, R.W.1    Morton, G.J.2    Morrison, C.D.3
  • 36
    • 45749158925 scopus 로고    scopus 로고
    • Central insulin action regulates peripheral glucose and fat metabolism in mice
    • Koch L, Wunderlich FT, Seibler J, et al. Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest. 2008;118:2132-2147.
    • (2008) J Clin Invest , vol.118 , pp. 2132-2147
    • Koch, L.1    Wunderlich, F.T.2    Seibler, J.3
  • 37
    • 78951469821 scopus 로고    scopus 로고
    • The role of lipid peroxidation products and oxidative stress in activation of the canonical winglesstype MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy
    • Zhou T, Zhou KK, Lee K, et al. The role of lipid peroxidation products and oxidative stress in activation of the canonical winglesstype MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. Diabetologia. 2010;54:459-468.
    • (2010) Diabetologia , vol.54 , pp. 459-468
    • Zhou, T.1    Zhou, K.K.2    Lee, K.3
  • 38
    • 33847656105 scopus 로고    scopus 로고
    • LRP6 mutation in a family with early coronary disease and metabolic risk factors
    • Mani A, Radhakrishnan J, Wang H, et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science. 2007;315:1278-1282.
    • (2007) Science , vol.315 , pp. 1278-1282
    • Mani, A.1    Radhakrishnan, J.2    Wang, H.3
  • 39
    • 0442276554 scopus 로고    scopus 로고
    • The glamour and gloom of glycogen synthase kinase-3
    • Jope RS, Johnson GV. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci. 2004;29:95-102.
    • (2004) Trends Biochem Sci , vol.29 , pp. 95-102
    • Jope, R.S.1    Johnson, G.V.2


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