Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations

Biochemistry

Volumn 53, Issue 25, 2014, Pages 4136-4151

  Yu, Zhi Hong ^a   Zhang, Ruo Yu ^a   Walls, Chad D ^a   Chen, Lan ^a   Zhang, Sheng ^a   Wu, Li ^a   Liu, Sijiu ^a   Zhang, Zhong Yin ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CHEMICAL ACTIVATION; LIGANDS; PROTEINS; SUBSTRATES;

ALLOSTERIC INHIBITION; CATALYTIC FUNCTIONALITIES; DEVELOPMENTAL DISORDERS; DOMAIN-CONTAINING PROTEINS; GROWTH FACTOR RECEPTORS; INTRAMOLECULAR INTERACTIONS; PHOSPHATASE ACTIVITY; PROTEIN-TYROSINE PHOSPHATASE;

PHOSPHATASES;

ADAPTOR PROTEIN; GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; TYROSINE;

ALLOSTERISM; ARTICLE; AUTOSOMAL DOMINANT DISORDER; ENZYME ACTIVATION; ENZYME MECHANISM; GAIN OF FUNCTION MUTATION; GERMLINE MUTATION; HUMAN; HUMAN CELL; LEOPARD SYNDROME; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NOONAN SYNDROME; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WILD TYPE;

ENZYME ACTIVATION; HEK293 CELLS; HUMANS; KINETICS; LEOPARD SYNDROME; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; SRC HOMOLOGY DOMAINS;

EID: 84903703387     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5002695     Document Type: Article

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