Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

Science

Volumn 345, Issue 6192, 2014, Pages 50-54

  Iversen, Lars ^a,f   Tu, Hsiung Lin ^a   Lin, Wan Chen ^a   Christensen, Sune M ^a,f   Abel, Steven M ^b,i   Iwig, Jeff ^a   Wu, Hung Jen ^a,j   Gureasko, Jodi ^a,k   Rhodes, Christopher ^c   Petit, Rebecca S ^a   Hansen, Scott D ^a   Thill, Peter ^d   Yu, Cheng Han ^e,l   Stamou, Dimitrios ^f   Chakraborty, Arup K ^b,d   Kuriyan, John ^a,g   Groves, Jay T ^a,e,g,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^h BERKELEY EDUCATION ALLIANCE FOR RESEARCH IN SINGAPORE   (Singapore)

ⁱ University of Tennessee Knoxville   (United States)

^j Texas AandM University   (United States)

^k EPIZYME INC   (United States)

^l UNIVERSITY OF HONG KONG   (Hong Kong)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; RAS PROTEIN; SOS PROTEIN; NUCLEOTIDE; PROTEIN P21;

CATALYSIS; ENZYME ACTIVITY; MEMBRANE; PROTEIN; SAMPLING;

ALLOSTERISM; ARTICLE; CATALYSIS; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; CHEMISTRY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; GENETICS; HUMAN; KINETICS; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; KINETICS; NUCLEOTIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTO-ONCOGENE PROTEINS P21(RAS); SON OF SEVENLESS PROTEIN, DROSOPHILA;

EID: 84903699445     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1250373     Document Type: Article

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