메뉴 건너뛰기




Volumn 20, Issue 15, 2014, Pages 2520-2524

Disruption of zinc neuromodulation by Aß oligomers: Therapeutic implications

Author keywords

Alzheimer's disease; Amyloid beta; Oligomers; Synapses; Zinc

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN OLIGOMER; N METHYL DEXTRO ASPARTIC ACID; OLIGOMER; UNCLASSIFIED DRUG; ZINC;

EID: 84903697696     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990510     Document Type: Article
Times cited : (6)

References (82)
  • 1
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue LF, Kuo YM, Roher AE, et al. Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999; 155: 853-62.
    • (1999) Am J Pathol , vol.155 , pp. 853-862
    • Lue, L.F.1    Kuo, Y.M.2    Roher, A.E.3
  • 2
    • 0038117796 scopus 로고    scopus 로고
    • Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
    • Naslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA: the J Am Med Assoc 2000; 283: 1571-7.
    • (2000) JAMA: The J Am Med Assoc , vol.283 , pp. 1571-1577
    • Naslund, J.1    Haroutunian, V.2    Mohs, R.3
  • 3
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP, Barlow AK, Chromy BA, et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 1998; 95: 6448-53.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6448-6453
    • Lambert, M.P.1    Barlow, A.K.2    Chromy, B.A.3
  • 4
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3
  • 5
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesne S, Koh MT, Kotilinek L, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440: 352-7.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3
  • 6
    • 65249093004 scopus 로고    scopus 로고
    • A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses
    • Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci 2009; 29: 4004-15.
    • (2009) J Neurosci , vol.29 , pp. 4004-4015
    • Deshpande, A.1    Kawai, H.2    Metherate, R.3    Glabe, C.G.4    Busciglio, J.5
  • 7
    • 23044445669 scopus 로고    scopus 로고
    • Regulation of NMDA receptor trafficking by amyloid-beta
    • Snyder EM, Nong Y, Almeida CG, et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nature Neurosci 2005; 8: 1051-8.
    • (2005) Nature Neurosci , vol.8 , pp. 1051-1058
    • Snyder, E.M.1    Nong, Y.2    Almeida, C.G.3
  • 8
    • 79952454330 scopus 로고    scopus 로고
    • Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of beta-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices
    • Rammes G, Hasenjager A, Sroka-Saidi K, Deussing JM, Parsons CG. Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of beta-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. Neuropharmacology 2011; 60: 982-90.
    • (2011) Neuropharmacology , vol.60 , pp. 982-990
    • Rammes, G.1    Hasenjager, A.2    Sroka-Saidi, K.3    Deussing, J.M.4    Parsons, C.G.5
  • 9
    • 78650505187 scopus 로고    scopus 로고
    • Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AbetaPP23 transgenic mice
    • Balducci C, Tonini R, Zianni E, et al. Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AbetaPP23 transgenic mice. J Alzheimer's disease: JAD 2010; 21: 1367-81.
    • (2010) J Alzheimer's disease: JAD , vol.21 , pp. 1367-1381
    • Balducci, C.1    Tonini, R.2    Zianni, E.3
  • 11
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimerrelated changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimerrelated changes. Acta Neuropathologica 1991; 82: 239-59.
    • (1991) Acta Neuropathologica , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 12
    • 0033986037 scopus 로고    scopus 로고
    • Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
    • Suh SW, Jensen KB, Jensen MS, et al. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 2000; 852: 274-8.
    • (2000) Brain Res , vol.852 , pp. 274-278
    • Suh, S.W.1    Jensen, K.B.2    Jensen, M.S.3
  • 13
    • 33646423857 scopus 로고    scopus 로고
    • Zinc-induced aggregation of Abeta (10-21) potentiates its action on voltage-gated potassium channel
    • Zhang CF, Yang P. Zinc-induced aggregation of Abeta (10-21) potentiates its action on voltage-gated potassium channel. Biochem Biophys Res Communicat 2006; 345: 43-9.
    • (2006) Biochem Biophys Res Communicat , vol.345 , pp. 43-49
    • Zhang, C.F.1    Yang, P.2
  • 14
    • 34548668652 scopus 로고    scopus 로고
    • Zinc lowers amyloid-beta toxicity by selectively precipitating aggregation intermediates
    • Garai K, Sahoo B, Kaushalya SK, Desai R, Maiti S. Zinc lowers amyloid-beta toxicity by selectively precipitating aggregation intermediates. Biochemistry 2007; 46: 10655-63.
    • (2007) Biochemistry , vol.46 , pp. 10655-10663
    • Garai, K.1    Sahoo, B.2    Kaushalya, S.K.3    Desai, R.4    Maiti, S.5
  • 15
    • 78650719200 scopus 로고    scopus 로고
    • Zinc overload enhances APP cleavage and Abeta deposition in the Alzheimer mouse brain
    • Wang CY, Wang T, Zheng W, et al. Zinc overload enhances APP cleavage and Abeta deposition in the Alzheimer mouse brain. PloS one 2010; 5: e15349.
    • (2010) PloS one , vol.5
    • Wang, C.Y.1    Wang, T.2    Zheng, W.3
  • 16
    • 33644867988 scopus 로고    scopus 로고
    • Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging
    • Zirah S, Kozin SA, Mazur AK, et al. Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging. J Biological Chem 2006; 281: 2151-61.
    • (2006) J Biological Chem , vol.281 , pp. 2151-2161
    • Zirah, S.1    Kozin, S.A.2    Mazur, A.K.3
  • 17
    • 48649105912 scopus 로고    scopus 로고
    • Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide
    • Tsvetkov PO, Popov IA, Nikolaev EN, et al. Isomerization of the Asp7 residue results in zinc-induced oligomerization of Alzheimer's disease amyloid beta(1-16) peptide. Chembiochem: a Eur J Chem Biol 2008; 9: 1564-7.
    • (2008) Chembiochem: A Eur J Chem Biol , vol.9 , pp. 1564-1567
    • Tsvetkov, P.O.1    Popov, I.A.2    Nikolaev, E.N.3
  • 18
    • 0025853543 scopus 로고
    • Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain research
    • Johnstone EM, Chaney MO, Norris FH, Pascual R, Little SP. Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis. Brain research. Molecular Brain Res 1991; 10: 299-305.
    • (1991) Molecular Brain Res , vol.10 , pp. 299-305
    • Johnstone, E.M.1    Chaney, M.O.2    Norris, F.H.3    Pascual, R.4    Little, S.P.5
  • 19
    • 0027980901 scopus 로고
    • Rapid induction of Alzheimer A beta amyloid formation by zinc
    • Bush AI, Pettingell WH, Multhaup G, et al. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1994; 265: 1464-7.
    • (1994) Science , vol.265 , pp. 1464-1467
    • Bush, A.I.1    Pettingell, W.H.2    Multhaup, G.3
  • 20
    • 3943055547 scopus 로고    scopus 로고
    • The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: Insights into the scarcity of amyloid deposition in aged rat brain
    • Huang J, Yao Y, Lin J, et al. The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: insights into the scarcity of amyloid deposition in aged rat brain. J Biol Inorg Chem 2004; 9: 627-35.
    • (2004) J Biol Inorg Chem , vol.9 , pp. 627-635
    • Huang, J.1    Yao, Y.2    Lin, J.3
  • 21
    • 61849148857 scopus 로고    scopus 로고
    • Mechanism of zinc(II)-promoted amyloid formation: Zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28)
    • Talmard C, Leuma Yona R, Faller P. Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28). J Biol Inorg Chem 2009; 14: 449-55.
    • (2009) J Biol Inorg Chem , vol.14 , pp. 449-455
    • Talmard, C.1    Leuma Yona, R.2    Faller, P.3
  • 22
    • 39749137469 scopus 로고    scopus 로고
    • Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide
    • Tougu V, Karafin A, Palumaa P. Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide. J Neurochem 2008; 104: 1249-59.
    • (2008) J Neurochem , vol.104 , pp. 1249-1259
    • Tougu, V.1    Karafin, A.2    Palumaa, P.3
  • 23
    • 38649112930 scopus 로고    scopus 로고
    • Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species
    • Noy D, Solomonov I, Sinkevich O, et al. Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species. J Am Chem Soc 2008; 130: 1376-83.
    • (2008) J Am Chem Soc , vol.130 , pp. 1376-1383
    • Noy, D.1    Solomonov, I.2    Sinkevich, O.3
  • 24
    • 77949423502 scopus 로고    scopus 로고
    • Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability
    • Baum L, Chan IH, Cheung SK, et al. Serum zinc is decreased in Alzheimer's disease and serum arsenic correlates positively with cognitive ability. Biometals: an Int J Role Metal Ions Biol, Biochem, Med 2010; 23: 173-9.
    • (2010) Biometals: An Int J Role Metal Ions Biol, Biochem, Med , vol.23 , pp. 173-179
    • Baum, L.1    Chan, I.H.2    Cheung, S.K.3
  • 25
    • 0141483385 scopus 로고    scopus 로고
    • Copper, zinc, and the metallobiology of Alzheimer disease
    • Bush AI. Copper, zinc, and the metallobiology of Alzheimer disease. Alzheimer Disease Associated Disorders 2003; 17: 147-50.
    • (2003) Alzheimer Disease Associated Disorders , vol.17 , pp. 147-150
    • Bush, A.I.1
  • 26
    • 42049094912 scopus 로고    scopus 로고
    • Altered oxidantmediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease
    • Sensi SL, Rapposelli IG, Frazzini V, Mascetra N. Altered oxidantmediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease. Exp Gerontol 2008; 43: 488-92.
    • (2008) Exp Gerontol , vol.43 , pp. 488-492
    • Sensi, S.L.1    Rapposelli, I.G.2    Frazzini, V.3    Mascetra, N.4
  • 27
    • 76149093866 scopus 로고    scopus 로고
    • Cognitive loss in zinc transporter-3 knock-out mice: A phenocopy for the synaptic and memory deficits of Alzheimer's disease?
    • Adlard PA, Parncutt JM, Finkelstein DI, Bush AI. Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? J Neuroscience: the official J Soc Neurosci 2010; 30: 1631-6.
    • (2010) J Neuroscience: The official J Soc Neurosci , vol.30 , pp. 1631-1636
    • Adlard, P.A.1    Parncutt, J.M.2    Finkelstein, D.I.3    Bush, A.I.4
  • 28
    • 0036429178 scopus 로고    scopus 로고
    • Developmental expression of ZnT3 in mouse brain: Correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact
    • Valente T, Auladell C. Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact. Mol Cell Neurosci 2002; 21: 189-204.
    • (2002) Mol Cell Neurosci , vol.21 , pp. 189-204
    • Valente, T.1    Auladell, C.2
  • 29
    • 35348863706 scopus 로고    scopus 로고
    • Zinc distribution and expression pattern of ZnT3 in mouse brain
    • Shen H, Zhang Y, Xu J, et al. Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res 2007; 119: 166-74.
    • (2007) Biol Trace Elem Res , vol.119 , pp. 166-174
    • Shen, H.1    Zhang, Y.2    Xu, J.3
  • 30
    • 0021866385 scopus 로고
    • Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study
    • Perez-Clausell J, Danscher G. Intravesicular localization of zinc in rat telencephalic boutons. A histochemical study. Brain Res 1985; 337: 91-8.
    • (1985) Brain Res , vol.337 , pp. 91-98
    • Perez-Clausell, J.1    Danscher, G.2
  • 32
    • 0034650875 scopus 로고    scopus 로고
    • Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors
    • Laube B, Kuhse J, Betz H. Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors. J Physiol 2000; 522 Pt 2: 215-30.
    • (2000) J Physiol , vol.522 , Issue.Pt 2 , pp. 215-230
    • Laube, B.1    Kuhse, J.2    Betz, H.3
  • 33
    • 27844445687 scopus 로고    scopus 로고
    • Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors
    • Miller PS, Da Silva HM, Smart TG. Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors. J Biol Chem 2005; 280: 37877-84.
    • (2005) J Biol Chem , vol.280 , pp. 37877-37884
    • Miller, P.S.1    Da Silva, H.M.2    Smart, T.G.3
  • 34
    • 37549044271 scopus 로고    scopus 로고
    • Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons
    • Zhang HX, Thio LL. Zinc enhances the inhibitory effects of strychnine-sensitive glycine receptors in mouse hippocampal neurons. J Neurophysiol 2007; 98: 3666-76.
    • (2007) J Neurophysiol , vol.98 , pp. 3666-3676
    • Zhang, H.X.1    Thio, L.L.2
  • 35
    • 17844394176 scopus 로고    scopus 로고
    • Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission
    • Cohen-Kfir E, Lee W, Eskandari S, Nelson N. Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission. Proc Natl Acad Sci USA 2005; 102: 6154-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6154-6159
    • Cohen-Kfir, E.1    Lee, W.2    Eskandari, S.3    Nelson, N.4
  • 36
    • 2542493963 scopus 로고    scopus 로고
    • Zn2+ inhibits glycine transport by glycine transporter subtype 1b
    • Ju P, Aubrey KR, Vandenberg RJ. Zn2+ inhibits glycine transport by glycine transporter subtype 1b. J Biological Chem 2004; 279: 22983-91.
    • (2004) J Biological Chem , vol.279 , pp. 22983-22991
    • Ju, P.1    Aubrey, K.R.2    Vandenberg, R.J.3
  • 37
    • 0025053207 scopus 로고
    • The inhibition of single N-methyl-Daspartate-activated channels by zinc ions on cultured rat neurones
    • Legendre P, Westbrook GL. The inhibition of single N-methyl-Daspartate-activated channels by zinc ions on cultured rat neurones. J Physiol 1990; 429: 429-49.
    • (1990) J Physiol , vol.429 , pp. 429-449
    • Legendre, P.1    Westbrook, G.L.2
  • 38
    • 38849170353 scopus 로고    scopus 로고
    • Zinc inhibition of rat NR1/NR2A Nmethyl-D-aspartate receptors
    • Erreger K, Traynelis SF. Zinc inhibition of rat NR1/NR2A Nmethyl-D-aspartate receptors. J Physiol 2008; 586: 763-78.
    • (2008) J Physiol , vol.586 , pp. 763-778
    • Erreger, K.1    Traynelis, S.F.2
  • 39
    • 33746223009 scopus 로고    scopus 로고
    • Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors
    • Izumi Y, Auberson YP, Zorumski CF. Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. J Neurosci 2006; 26: 7181-8.
    • (2006) J Neurosci , vol.26 , pp. 7181-7188
    • Izumi, Y.1    Auberson, Y.P.2    Zorumski, C.F.3
  • 40
    • 0033712121 scopus 로고    scopus 로고
    • The actions of synaptically released zinc at hippocampal mossy fiber synapses
    • Vogt K, Mellor J, Tong G, Nicoll R. The actions of synaptically released zinc at hippocampal mossy fiber synapses. Neuron 2000; 26: 187-96.
    • (2000) Neuron , vol.26 , pp. 187-196
    • Vogt, K.1    Mellor, J.2    Tong, G.3    Nicoll, R.4
  • 41
    • 79952744484 scopus 로고    scopus 로고
    • Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory
    • Sindreu C, Palmiter RD, Storm DR. Zinc transporter ZnT-3 regulates presynaptic Erk1/2 signaling and hippocampus-dependent memory. Proc Natl Acad Sci USA 2011; 108: 3366-70.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3366-3370
    • Sindreu, C.1    Palmiter, R.D.2    Storm, D.R.3
  • 42
    • 15744365886 scopus 로고    scopus 로고
    • Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases
    • Hwang JJ, Park MH, Choi SY, Koh JY. Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases. J Biol Chem 2005; 280: 11995-2001.
    • (2005) J Biol Chem , vol.280 , pp. 11995-12001
    • Hwang, J.J.1    Park, M.H.2    Choi, S.Y.3    Koh, J.Y.4
  • 43
    • 39449099067 scopus 로고    scopus 로고
    • Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse
    • Huang YZ, Pan E, Xiong ZQ, McNamara JO. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse. Neuron 2008; 57: 546-58.
    • (2008) Neuron , vol.57 , pp. 546-558
    • Huang, Y.Z.1    Pan, E.2    Xiong, Z.Q.3    McNamara, J.O.4
  • 44
    • 79551596834 scopus 로고    scopus 로고
    • Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
    • Grabrucker AM, Knight MJ, Proepper C, et al. Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO Journal 2011; 30: 569-81.
    • (2011) EMBO Journal , vol.30 , pp. 569-581
    • Grabrucker, A.M.1    Knight, M.J.2    Proepper, C.3
  • 45
    • 0346099094 scopus 로고    scopus 로고
    • Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus
    • Takeda A, Minami A, Seki Y, Oku N. Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus. J Neurosci Res 2004; 75: 225-9.
    • (2004) J Neurosci Res , vol.75 , pp. 225-229
    • Takeda, A.1    Minami, A.2    Seki, Y.3    Oku, N.4
  • 46
    • 38849170353 scopus 로고    scopus 로고
    • Zinc inhibition of rat NR1/NR2A Nmethyl-D-aspartate receptors
    • Erreger K, Traynelis SF. Zinc inhibition of rat NR1/NR2A Nmethyl-D-aspartate receptors. J Physiol 2008; 586: 763-78.
    • (2008) J Physiol , vol.586 , pp. 763-778
    • Erreger, K.1    Traynelis, S.F.2
  • 47
    • 0030746608 scopus 로고    scopus 로고
    • High-affinity zinc inhibition of NMDA NR1-NR2A receptors
    • Paoletti P, Ascher P, Neyton J. High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 1997; 17: 5711-25.
    • (1997) J Neurosci , vol.17 , pp. 5711-5725
    • Paoletti, P.1    Ascher, P.2    Neyton, J.3
  • 48
    • 70350220417 scopus 로고    scopus 로고
    • Zinc in the physiology and pathology of the CNS. Nature reviews
    • Sensi SL, Paoletti P, Bush AI, Sekler I. Zinc in the physiology and pathology of the CNS. Nature reviews. Neuroscience 2009; 10: 780-91.
    • (2009) Neuroscience , vol.10 , pp. 780-791
    • Sensi, S.L.1    Paoletti, P.2    Bush, A.I.3    Sekler, I.4
  • 49
    • 2142821384 scopus 로고    scopus 로고
    • Characterization of extracellular accumulation of Zn2+ during ischemia and reperfusion of hippocampus slices in rat
    • Wei G, Hough CJ, Li Y, Sarvey JM. Characterization of extracellular accumulation of Zn2+ during ischemia and reperfusion of hippocampus slices in rat. Neuroscience 2004; 125: 867-77.
    • (2004) Neuroscience , vol.125 , pp. 867-877
    • Wei, G.1    Hough, C.J.2    Li, Y.3    Sarvey, J.M.4
  • 50
    • 0033988750 scopus 로고    scopus 로고
    • Evidence that synapticallyreleased zinc contributes to neuronal injury after traumatic brain injury
    • Suh SW, Chen JW, Motamedi M, et al. Evidence that synapticallyreleased zinc contributes to neuronal injury after traumatic brain injury. Brain Res 2000; 852: 268-73.
    • (2000) Brain Res , vol.852 , pp. 268-273
    • Suh, S.W.1    Chen, J.W.2    Motamedi, M.3
  • 51
    • 0033514513 scopus 로고    scopus 로고
    • Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production
    • Sensi SL, Yin HZ, Carriedo SG, Rao SS, Weiss JH. Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc Natl Acad Sci USA 1999; 96: 2414-9.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2414-2419
    • Sensi, S.L.1    Yin, H.Z.2    Carriedo, S.G.3    Rao, S.S.4    Weiss, J.H.5
  • 53
    • 78650905213 scopus 로고    scopus 로고
    • Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration
    • Qian J, Xu K, Yoo J, et al. Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. The J neuroscience: the official J the Society for Neuroscience 2011; 31: 97-104.
    • (2011) The J neuroscience: The official J the Society for Neuroscience , vol.31 , pp. 97-104
    • Qian, J.1    Xu, K.2    Yoo, J.3
  • 54
    • 63849152777 scopus 로고    scopus 로고
    • Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy
    • Elsas SM, Hazany S, Gregory WL, Mody I. Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. Epilepsia 2009; 50: 870-9.
    • (2009) Epilepsia , vol.50 , pp. 870-879
    • Elsas, S.M.1    Hazany, S.2    Gregory, W.L.3    Mody, I.4
  • 55
    • 33845769476 scopus 로고    scopus 로고
    • Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats
    • Lavoie N, Peralta MR, 3rd, Chiasson M, et al. Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats. J Physiol 2007; 578: 275-89.
    • (2007) J Physiol , vol.578 , pp. 275-289
    • Lavoie, N.1    Peralta III, M.R.2    Chiasson, M.3
  • 56
    • 33745274474 scopus 로고    scopus 로고
    • Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation
    • Dominguez MI, Blasco-Ibanez JM, Crespo C, et al. Neural overexcitation and implication of NMDA and AMPA receptors in a mouse model of temporal lobe epilepsy implying zinc chelation. Epilepsia 2006; 47: 887-99.
    • (2006) Epilepsia , vol.47 , pp. 887-899
    • Dominguez, M.I.1    Blasco-Ibanez, J.M.2    Crespo, C.3
  • 59
    • 33749522545 scopus 로고    scopus 로고
    • Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: An independent component analysis
    • Celone KA, Calhoun VD, Dickerson BC, et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. The J neuroscience: the official J Soc Neurosci 2006; 26: 10222-31.
    • (2006) The J neuroscience: The official J Soc Neurosci , vol.26 , pp. 10222-10231
    • Celone, K.A.1    Calhoun, V.D.2    Dickerson, B.C.3
  • 60
    • 23244445918 scopus 로고    scopus 로고
    • Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    • Dickerson BC, Salat DH, Greve DN, et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 2005; 65: 404-11.
    • (2005) Neurology , vol.65 , pp. 404-411
    • Dickerson, B.C.1    Salat, D.H.2    Greve, D.N.3
  • 61
    • 72449133293 scopus 로고    scopus 로고
    • Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: An example of brain reserve
    • Cohen AD, Price JC, Weissfeld LA, et al. Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve. The J neuroscience: the official J Soc Neurosci 2009; 29: 14770-8.
    • (2009) The J neuroscience: The official J Soc Neurosci , vol.29 , pp. 14770-14778
    • Cohen, A.D.1    Price, J.C.2    Weissfeld, L.A.3
  • 62
    • 44449158715 scopus 로고    scopus 로고
    • Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
    • Miller SL, Fenstermacher E, Bates J, et al. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J Neurol, Neurosurg, Psychiatry 2008; 79: 630-5.
    • (2008) J Neurol, Neurosurg, Psychiatry , vol.79 , pp. 630-635
    • Miller, S.L.1    Fenstermacher, E.2    Bates, J.3
  • 63
    • 77953776221 scopus 로고    scopus 로고
    • Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
    • O'Brien JL, O'Keefe KM, LaViolette PS, et al. Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology 2010; 74: 1969-76.
    • (2010) Neurology , vol.74 , pp. 1969-1976
    • O'Brien, J.L.1    O'Keefe, K.M.2    LaViolette, P.S.3
  • 64
    • 0019790481 scopus 로고
    • Brain aging correlates: Retardation by hormonal-pharmacological treatments
    • Landfield PW, Baskin RK, Pitler TA. Brain aging correlates: retardation by hormonal-pharmacological treatments. Science 1981; 214: 581-4.
    • (1981) Science , vol.214 , pp. 581-584
    • Landfield, P.W.1    Baskin, R.K.2    Pitler, T.A.3
  • 65
  • 66
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp PR, Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad SciUSA 1996; 93: 9926-30.
    • (1996) Proc Natl Acad SciUSA , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 67
    • 67849106894 scopus 로고    scopus 로고
    • Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease
    • Grossi C, Francese S, Casini A, et al. Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease. J Alzheimer's disease: JAD 2009; 17: 423-40.
    • (2009) J Alzheimer's disease: JAD , vol.17 , pp. 423-440
    • Grossi, C.1    Francese, S.2    Casini, A.3
  • 68
    • 46149107512 scopus 로고    scopus 로고
    • Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    • Adlard PA, Cherny RA, Finkelstein DI, et al. Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 2008; 59: 43-55.
    • (2008) Neuron , vol.59 , pp. 43-55
    • Adlard, P.A.1    Cherny, R.A.2    Finkelstein, D.I.3
  • 69
    • 0034964390 scopus 로고    scopus 로고
    • Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
    • Cherny RA, Atwood CS, Xilinas ME, et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 2001; 30: 665-76.
    • (2001) Neuron , vol.30 , pp. 665-676
    • Cherny, R.A.1    Atwood, C.S.2    Xilinas, M.E.3
  • 70
    • 79952610782 scopus 로고    scopus 로고
    • Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
    • Adlard PA, Bica L, White AR, et al. Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PloS one 2011; 6: e17669.
    • (2011) PloS one , vol.6
    • Adlard, P.A.1    Bica, L.2    White, A.R.3
  • 71
    • 48949098573 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
    • Lannfelt L, Blennow K, Zetterberg H, et al. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2008; 7: 779-86.
    • (2008) Lancet Neurol , vol.7 , pp. 779-786
    • Lannfelt, L.1    Blennow, K.2    Zetterberg, H.3
  • 72
    • 80052684579 scopus 로고    scopus 로고
    • The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity
    • Crouch PJ, Savva MS, Hung LW, et al. The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity. J Neurochem 2011.
    • (2011) J Neurochem
    • Crouch, P.J.1    Savva, M.S.2    Hung, L.W.3
  • 73
    • 33745258377 scopus 로고    scopus 로고
    • Incidence and predictors of seizures in patients with Alzheimer's disease
    • Amatniek JC, Hauser WA, DelCastillo-Castaneda C, et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 2006; 47: 867-72.
    • (2006) Epilepsia , vol.47 , pp. 867-872
    • Amatniek, J.C.1    Hauser, W.A.2    DelCastillo-Castaneda, C.3
  • 74
    • 33747392556 scopus 로고    scopus 로고
    • Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease
    • Lozsadi DA, Larner AJ. Prevalence and causes of seizures at the time of diagnosis of probable Alzheimer's disease. Dement Geriatr Cogn Disord 2006; 22: 121-4.
    • (2006) Dement Geriatr Cogn Disord , vol.22 , pp. 121-124
    • Lozsadi, D.A.1    Larner, A.J.2
  • 76
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • Palop JJ, Chin J, Roberson ED, et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007; 55: 697-711.
    • (2007) Neuron , vol.55 , pp. 697-711
    • Palop, J.J.1    Chin, J.2    Roberson, E.D.3
  • 77
    • 63849180498 scopus 로고    scopus 로고
    • Amyloid betainduced neuronal hyperexcitability triggers progressive epilepsy
    • Minkeviciene R, Rheims S, Dobszay MB, et al. Amyloid betainduced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 2009; 29: 3453-62.
    • (2009) J Neurosci , vol.29 , pp. 3453-3462
    • Minkeviciene, R.1    Rheims, S.2    Dobszay, M.B.3
  • 78
    • 84863989795 scopus 로고    scopus 로고
    • Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice
    • Hunter JM, Cirrito JR, Restivo JL, et al. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Res 2012; 1467: 120-32.
    • (2012) Brain Res , vol.1467 , pp. 120-132
    • Hunter, J.M.1    Cirrito, J.R.2    Restivo, J.L.3
  • 79
    • 84867645474 scopus 로고    scopus 로고
    • Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model
    • Sanchez PE, Zhu L, Verret L, et al. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Nat Acad Sci USA 2012; 109: E2895-903.
    • (2012) Proc Nat Acad Sci USA , vol.109
    • Sanchez, P.E.1    Zhu, L.2    Verret, L.3
  • 80
    • 79952386386 scopus 로고    scopus 로고
    • Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels
    • Ziyatdinova S, Gurevicius K, Kutchiashvili N, et al. Spontaneous epileptiform discharges in a mouse model of Alzheimer's disease are suppressed by antiepileptic drugs that block sodium channels. Epilepsy Res 2011; 94: 75-85.
    • (2011) Epilepsy Res , vol.94 , pp. 75-85
    • Ziyatdinova, S.1    Gurevicius, K.2    Kutchiashvili, N.3
  • 81
    • 84860659903 scopus 로고    scopus 로고
    • Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
    • Bakker A, Krauss GL, Albert MS, et al. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012; 74: 467-74.
    • (2012) Neuron , vol.74 , pp. 467-474
    • Bakker, A.1    Krauss, G.L.2    Albert, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.