The analgesic and anti-inflammatory effects of Litsea japonica fruit are mediated via suppression of NF-κB and JNK/p38 MAPK activation

International Immunopharmacology

Volumn 22, Issue 1, 2014, Pages 84-97

  Koo, Hyun Jung ^a   Yoon, Weon Jong ^b   Sohn, Eun Hwa ^c   Ham, Young Min ^b   Jang, Seon A ^a   Kwon, Jung Eun ^a   Jeong, Yong Joon ^a   Kwak, Jong Hwan ^d   Sohn, Eunsoo ^e   Park, Soo Young ^b   Jang, Ki Hyo ^c   Namkoong, Seung ^c   Han, Hyo Sang ^f   Jung, Yong Hwan ^b   Kang, Se Chan ^a  

^a Gachon University College of Medicine   (South Korea)

^b Jeju Biodiversity Research Institute   (South Korea)

^c Kangwon National University   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Korea Institute of Science and Technology Information (KISTI)   (South Korea)

^f Joongbu University   (South Korea)

Author keywords

Analgesic; Anti inflammatory; Cyclooxygenase 2; Hamabiwalactone; Litsea japonica

Indexed keywords

ALCOHOL; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; CYCLOOXYGENASE 2; DICHLOROMETHANE; HAMABIWALACTONE A; HAMABIWALACTONE B; HERBACEOUS AGENT; HEXANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; LITSEA JAPONICA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; FURAN DERIVATIVE; GAMMA BUTYROLACTONE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NONSTEROID ANTIINFLAMMATORY AGENT; PTGS2 PROTEIN, MOUSE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; DISEASE MODEL; DRUG EFFECTS; HUMAN; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; LITSEA; METABOLISM; PHYTOTHERAPY;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; DISEASE MODELS, ANIMAL; FRUIT; FURANS; HUMANS; IMMUNOSUPPRESSION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LITSEA; MACROPHAGES; MALE; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PAIN; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84903688489     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.06.007     Document Type: Article

References (55)

1. D. Salvemini, T.P. Misko, J.L. Masferrer, K. Seibert, M.G. Currie, and P. Needleman Nitric oxide activates cyclooxygenase enzymes Proc Natl Acad Sci U S A 90 1993 7240 7244 (Pubitemid 23222425)
2. T. Lawrence, D.A. Willoughby, and D.W. Gilroy Anti-inflammatory lipid mediators and insights into the resolution of inflammation Nat Rev Immunol 2 2002 787 795 (Pubitemid 37328718)
3. T.J. Guzik, R. Korbut, and T. Adamek-Guzik Nitric oxide and superoxide in inflammation and immune regulation J Physiol Pharmacol 54 2003 469 487 (Pubitemid 38029745)
4. J.B. Kim, A.R. Han, E.Y. Park, J.Y. Kim, W. Cho, and J. Lee et al. Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells Biol Pharm Bull 30 2007 2345 2351 (Pubitemid 350223740)
5. D. Julius, and A.I. Basbaum Molecular mechanisms of nociception Nature 413 2001 203 210 (Pubitemid 32867885)
6. L.R. Watkins, and S.F. Maier Immune regulation of central nervous system functions: from sickness responses to pathological pain J Intern Med 257 2005 139 155 (Pubitemid 40193964)
7. K. Ren, and R. Dubner Interactions between the immune and nervous systems in pain Nat Med 16 2010 1267 1276
8. J.J. O'Shea, A. Ma, and P. Lipsky Cytokines and autoimmunity Nat Rev Immunol 2 2002 37 45 (Pubitemid 37328774)
9. S.M. Nanjundaiah, S.H. Venkatesha, H. Yu, L. Tong, J.P. Stains, and K.D. Moudgil Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk J Biol Chem 287 2012 22216 22226
10. B. Renner, G. Walter, J. Strauss, M.F. Fromm, J. Zacher, and K. Brune Preoperative administration of etoricoxib in patients undergoing hip replacement causes inhibition of inflammatory mediators and pain relief Eur J Pain 16 2012 838 848
11. M.F. Shih, L.Y. Chen, P.J. Tsai, and J.Y. Cherng In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice Int J Immunopathol Pharmacol 25 2012 39 48
12. C.K. Ong, P. Lirk, C.H. Tan, and R.A. Seymour An evidence-based update on nonsteroidal anti-inflammatory drugs Clin Med Res 5 2007 19 34 (Pubitemid 350218777)
13. W. Zhang, M. Doherty, N. Arden, B. Bannwarth, J. Bijlsma, and K.P. Gunther et al. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT) Ann Rheum Dis 64 2005 669 681 (Pubitemid 40559291)
14. P.A. Scott, G.H. Kingsley, C.M. Smith, E.H. Choy, and D.L. Scott Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomised controlled trials Ann Rheum Dis 66 2007 1296 1304 (Pubitemid 47492471)
15. K. Kazłowska, T. Hsu, C.C. Hou, W.C. Yang, and G.J. Tsai Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata J Ethnopharmacol 128 2010 123 130
16. S.J. Heo, W.J. Yoon, K.N. Kim, C. Oh, Y.U. Choi, and K.T. Yoon et al. Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage Food Chem Toxicol 50 2012 3336 3342
17. Q. Zhu, C. Liao, Y. Liu, P. Wang, W. Guo, and M. He et al. Ethanolic extract and water-soluble polysaccharide from Chaenomeles speciosa fruit modulate lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells J Ethnopharmacol 144 2012 441 447
18. B.S. Min, S.Y. Lee, J.H. Kim, O.K. Kwon, B.Y. Park, and R.B. An et al. Lactones from the leaves of Litsea japonica and their anti-complement activity J Nat Prod 66 2003 1388 1390 (Pubitemid 37323410)
19. S.L. Guzmán-Gutiérrez, R. Gómez-Cansino, J.C. García-Zebadúa, N.C. Jiménez-Pérez, and R. Reyes-Chilpa Antidepressant activity of Litsea glaucescens essential oil: identification of β-pinene and linalool as active principles J Ethnopharmacol 143 2012 673 679
20. N. Jiménez-Pérez, N. Jiménez-Pérez, C. del, F.G. Lorea-Hernández, C.K. Jankowski, and R. Reyes-Chilpa Essential oils in Mexican Bays (Litsea spp., Lauraceae): taxonomic assortment and ethnobotanical implications Econ Bot 65 2011 178 189
21. J. Kim, C.S. Kim, I.S. Lee, Y.M. Lee, E. Sohn, and K. Jo et al. Extract of Litsea japonica ameliorates blood-retinal barrier breakdown in db/db mice Endocrine 2013 [Epub ahead of print]
22. E. Sohn, J. Kim, C.S. Kim, Y.M. Lee, K. Jo, and S.D. Shin et al. The extract of Litsea japonica reduced the development of diabetic nephropathy via the inhibition of advanced glycation end products accumulation in db/db mice Evid Based Complement Alternat Med 2013 2013 769416
23. W.J. Yoon, S.C. Kang, Y.M. Ham, K.N. Kim, W.H. Yang, and H.J. Kim et al. Antioxidative and anti-inflammatory activities of Litsea japonica leaves J Korean Soc Appl Biol Chem 53 2010 27 32
24. Ts Ahmed, M. Magaji, A. Yaro, A. Musa, and A. Adamu Aqueous methanol extracts of Cochlospermum tinctorium (A. Rich) possess analgesic and anti-inflammatory activities J Young Pharm 3 2011 237 242
25. N.B. Eddy, and D. Leimbach Synthetic analgesics. II. Dithienylbutenyl- and dithienyl-butylamines J Pharmacol Exp Ther 107 1953 385 393
26. X. Li, M. Ellman, P. Muddasani, J.H. Wang, G. Cs-Szabo, and A.J. van Wijnen et al. Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis Arthritis Rheum 60 2009 513 523
27. H.L. Pahl Activators and target genes of Rel/NF-kappaB transcription factors Oncogene 18 1999 6853 6866
28. K.G. Waddick, and F.M. Uckun Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target Biochem Pharmacol 57 1999 9 17 (Pubitemid 29012491)
29. J.D. Levine, and D.B. Reichling Peripheral mechanisms of inflammatory pain P.D. Wall, R. Melzack, Textbook of Pain 4th ed. 1999 59 84 Edinburgh: Churchill Livingstone
30. B. Malik, and M. Stillman Pain syndromes S. Savitz, M. Ronthal, Neurology review for psychiatrists 1st ed. 2009 Lippincott Williams & Wilkins Philadelphia 253 255
31. H.L. Rittner, H. Machelska, and C. Stein Leukocytes in the regulation of pain and analgesia J Leukoc Biol 78 2005 1215 1222 (Pubitemid 41779227)
32. X. Shu, and L.M. Mendell Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin Neurosci Lett 274 1999 159 162 (Pubitemid 29462536)
33. S.H. Ferreira, B.B. Lorenzetti, M.S.A. Castro, and F.M.A. Correa Antialgic effect of aspirin like drugs and the inhibition of prostaglandin synthesis D.C. Dumonde, M.K. Jasani, The recognition of anti-rheumatic drugs 1978 MTP Press Limited, St. Leonard House Lancaster 25 37
34. R. Deraedt, S. Jouquey, F. Delevallée, and M. Flahaut Release of prostaglandins E and F in an algogenic reaction and its inhibition Eur J Pharmacol 61 1980 17 24 (Pubitemid 10178021)
35. D.M. Dirig, P.C. Isakson, and T.L. Yaksh Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats J Pharmacol Exp Ther 285 1998 1031 1038 (Pubitemid 28277901)
36. A. Kawabata Lipid mediators and pain signaling. Foreword Biol Pharm Bull 34 2011 1153
37. S. Hazra, R.K. Batra, H.H. Tai, S. Sharma, X. Cui, and S.M. Dubinett Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase Mol Pharmacol 71 2007 1715 1720 (Pubitemid 47010924)
38. F. Kojima, H. Naraba, Y. Sasaki, R. Okamoto, T. Koshino, and S. Kawai Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells J Rheumatol 29 2002 1836 1842 (Pubitemid 34988689)
39. T.A. Swierkosz, J.A. Mitchell, T.D. Warner, R.M. Botting, and J.R. Vane Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids Br J Pharmacol 114 1995 1335 1342
40. I. Posadas, M.C. Terencio, I. Guillén, M.L. Ferrándiz, J. Coloma, and M. Payá et al. Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation Naunyn Schmiedebergs Arch Pharmacol 361 2000 98 106 (Pubitemid 30064661)
41. Y.J. Surh, K.S. Chun, H.H. Cha, S.S. Han, Y.S. Keum, and K.K. Park et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation Mutat Res 480-1 2001 243 268 (Pubitemid 32744832)
42. H. Holthusen, and J.O. Arndt Nitric oxide evokes pain in humans on intracutaneous injection Neurosci Lett 165 1994 71 74 (Pubitemid 24043243)
43. K.E. White, Q. Ding, B.B. Moore, M. Peters-Golden, L.B. Ware, and M.A. Matthay et al. Prostaglandin E2 mediates IL-1beta-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors J Immunol 180 2008 637 646
44. A. Inoue, K. Ikoma, N. Morioka, K. Kumagai, T. Hashimoto, and I. Hide et al. Interleukin-1beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system J Neurochem 73 1999 2206 2213 (Pubitemid 29491836)
45. D. Sachs, F.Q. Cunha, S. Poole, and S.H. Ferreira Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity Pain 96 2002 89 97 (Pubitemid 34272289)
46. C.J. Woolf Pain: moving from symptom control toward mechanism-specific pharmacologic management Ann Intern Med 140 2004 441 451 (Pubitemid 38327332)
47. B. Schöbitz, E.R. de Kloet, W. Sutanto, and F. Holsboer Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain Eur J Neurosci 5 1993 1426 1435 (Pubitemid 23325225)
48. L. Vallières, and S. Rivest Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta J Neurochem 69 1997 1668 1683 (Pubitemid 27406968)
49. Y. Oka, T. Ibuki, K. Matsumura, M. Namba, Y. Yamazaki, and S. Poole et al. Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS Neuroscience 145 2007 530 538 (Pubitemid 46341642)
50. N. Rajapakse, M.M. Kim, E. Mendis, and S.K. Kim Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-kappaB signaling Immunology 123 2008 348 357 (Pubitemid 351171187)
51. Y.J. Gao, and R.R. Ji Activation of JNK pathway in persistent pain Neurosci Lett 437 2008 180 183
52. Z.Y. Zhuang, Y.R. Wen, D.R. Zhang, T. Borsello, C. Bonny, and G.R. Strichartz et al. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance J Neurosci 26 2006 3551 3560
53. Y.J. Gao, J.K. Cheng, Q. Zeng, Z.Z. Xu, I. Decosterd, and X. Xu et al. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model Exp Neurol 219 2009 146 155
54. S.Y. Chang, M.J. Cheng, C.F. Peng, H.S. Chang, and I.S. Chen Antimycobacterial butanolides from the root of Lindera akoensis Chem Biodivers 5 2008 2690 2698
55. W. Cheng, C. Zhu, W. Xu, X. Fan, Y. Yang, and Y. Li et al. Chemical constituents of the bark of Machilus wangchiana and their biological activities J Nat Prod 72 2009 2145 2152