Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes

Journal of Immunology

Volumn 193, Issue 1, 2014, Pages 400-411

  Ford, Laura B ^a   Cerovic, Vuk ^a   Milling, Simon W F ^a   Graham, Gerard J ^a   Hansell, Chris A H ^a   Nibbs, Robert J B ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ACKR2; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LABELING; CHEMOTAXIS; CONTROLLED STUDY; IMMUNOREACTIVITY; INTERNALIZATION; LEUKOCYTE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM;

ANIMALS; CHEMOKINE CCL2; CHEMOKINE CCL7; DENDRITIC CELLS; MICE; MICE, KNOCKOUT; MONOCYTE CHEMOATTRACTANT PROTEINS; MONOCYTES; PLASMA CELLS; RECEPTORS, CHEMOKINE;

EID: 84903646889     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303236     Document Type: Article

References (51)

1. Zlotnik, A., and O. Yoshie. 2012. The chemokine superfamily revisited. Immunity 36: 705-716.
2. Bachelerie, F., A. Ben-Baruch, A. M. Burkhardt, C. Combadiere, J. M. Farber, G. J. Graham, R. Horuk, A. H. Sparre-Ulrich, M. Locati, A. D. Luster, et al. 2014. International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol. Rev. 66: 1-79.
3. Nibbs, R. J. B., and G. J. Graham. 2013. Immune regulation by atypical chemokine receptors. Nat. Rev. Immunol. 13: 815-829.
4. Volpe, S., E. Cameroni, B. Moepps, S. Thelen, T. Apuzzo, and M. Thelen. 2012. CCR2 acts as scavenger for CCL2 during monocyte chemotaxis. PLoS One 7: e37208.
5. Cardona, A. E., M. E. Sasse, L. Liu, S. M. Cardona, M. Mizutani, C. Savarin, T. Hu, and R. M. Ransohoff. 2008. Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues. Blood 112: 256-263.
6. Maus, U. A., S. Wellmann, C. Hampl, W. A. Kuziel, M. Srivastava, M. Mack, M. B. Everhart, T. S. Blackwell, J. W. Christman, D. Schlöndorff, et al. 2005. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L350-L358.
7. Tylaska, L. A., L. Boring, W. Weng, R. Aiello, I. F. Charo, B. J. Rollins, and R. P. Gladue. 2002. Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 18: 184-190. (Pubitemid 34775426)
8. van Helden, M. J. G., D. M. W. Zaiss, and A. J. A. M. Sijts. 2012. CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice. PLoS One 7: e52027.
9. Lança, T., M. F. Costa, N. Gonçalves-Sousa, M. Rei, A. R. Grosso, C. Penido, and B. Silva-Santos. 2013. Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic gd T lymphocytes to tumor beds. J. Immunol. 190: 6673-6680.
10. Serbina, N. V., and E. G. Pamer. 2006. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7: 311-317.
11. Sato, N., S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja. 2000. CC chemokine receptor (CCR)2 is required for Langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells: absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, B cell outgrowth, and sustained neutrophilic inflammation. J. Exp. Med. 192: 205-218. (Pubitemid 30470303)
12. Drobits, B., M. Holcmann, N. Amberg, M. Swiecki, R. Grundtner, M. Hammer, M. Colonna, and M. Sibilia. 2012. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J. Clin. Invest. 122: 575-585.
13. Jia, T., N. V. Serbina, K. Brandl, M. X. Zhong, I. M. Leiner, I. F. Charo, and E. G. Pamer. 2008. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J. Immunol. 180: 6846-6853.
14. Tsou, C.-L., W. Peters, Y. Si, S. Slaymaker, A. M. Aslanian, S. P. Weisberg, M. Mack, and I. F. Charo. 2007. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J. Clin. Invest. 117: 902-909. (Pubitemid 46556746)
15. Mayr, F. B., A. O. Spiel, J. M. Leitner, C. Firbas, J. Schnee, J. Hilbert, H. Derendorf, and B. Jilma. 2009. Influence of the Duffy antigen on pharmacokinetics and pharmacodynamics of recombinant monocyte chemoattractant protein (MCP-1, CCL-2) in vivo. Int. J. Immunopathol. Pharmacol. 22: 615-625.
16. Pruenster, M., L. Mudde, P. Bombosi, S. Dimitrova, M. Zsak, J. Middleton, A. Richmond, G. J. Graham, S. Segerer, R. J. B. Nibbs, and A. Rot. 2009. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat. Immunol. 10: 101-108.
17. Lee, J. S., C. W. Frevert, M. M. Wurfel, S. C. Peiper, V. A.Wong, K. K. Ballman, J. T. Ruzinski, J. S. Rhim, T. R. Martin, and R. B. Goodman. 2003. Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J. Immunol. 170: 5244-5251. (Pubitemid 36554758)
18. Nibbs, R. J., E. Kriehuber, P. D. Ponath, D. Parent, S. Qin, J. D. Campbell, A. Henderson, D. Kerjaschki, D. Maurer, G. J. Graham, and A. Rot. 2001. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am. J. Pathol. 158: 867-877. (Pubitemid 32221780)
19. Malhotra, D., A. L. Fletcher, J. Astarita, V. Lukacs-Kornek, P. Tayalia, S. F. Gonzalez, K. G. Elpek, S. K. Chang, K. Knoblich, M. E. Hemler, et al. 2012. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat. Immunol. 13: 499-510.
20. Hansell, C. A. H., C. Schiering, R. Kinstrie, L. Ford, Y. Bordon, I. B. McInnes, C. S. Goodyear, and R. J. B. Nibbs. 2011. Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. Blood 117:5413-5424.
21. Savino, B., M. G. Castor, N. Caronni, A. Sarukhan, A. Anselmo, C. Buracchi, F. Benvenuti, V. Pinho, M. M. Teixeira, A. Mantovani, et al. 2012. Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. Blood 119: 5250-5260.
22. Crosslin, D. R., A. McDavid, N. Weston, X. Zheng, E. Hart, M. de Andrade, I. J. Kullo, C. A. McCarty, K. F. Doheny, E. Pugh, et al. 2013. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum. Mol. Genet. 22: 2119-2127.
23. Weber, M., E. Blair, C. V. Simpson, M. O'Hara, P. E. Blackburn, A. Rot, G. J. Graham, and R. J. B. Nibbs. 2004. The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokines. Mol. Biol. Cell 15: 2492-2508. (Pubitemid 38580663)
24. Franci, C., J. Gosling, C. L. Tsou, S. R. Coughlin, and I. F. Charo. 1996. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor: critical role of carboxyl-tail serines/threonines in receptor function. J. Immunol. 157: 5606-5612. (Pubitemid 126448984)
25. Boring, L., J. Gosling, S. W. Chensue, S. L. Kunkel, R. V. Farese, Jr., H. E. Broxmeyer, and I. F. Charo. 1997. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100: 2552-2561. (Pubitemid 27514895)
26. Mach, N., S. Gillessen, S. B. Wilson, C. Sheehan, M. Mihm, and G. Dranoff. 2000. Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res. 60: 3239-3246. (Pubitemid 30407923)
27. Flaishon, L., S. Becker-Herman, G. Hart, Y. Levo, W. A. Kuziel, and I. Shachar. 2004. Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration. Blood 104: 933-941. (Pubitemid 39038011)
28. Delogu, A., A. Schebesta, Q. Sun, K. Aschenbrenner, T. Perlot, and M. Busslinger. 2006. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity 24: 269-281.
29. Mack, M., J. Cihak, C. Simonis, B. Luckow, A. E. Proudfoot, J. Plachý, H. Brüuhl, M. Frink, H. J. Anders, V. Vielhauer, et al. 2001. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J. Immunol. 166: 4697-4704. (Pubitemid 32233757)
30. Wendland, M., N. Czeloth, N. Mach, B. Malissen, E. Kremmer, O. Pabst, and R. Förster. 2007. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc. Natl. Acad. Sci. USA 104: 6347-6352. (Pubitemid 47186097)
31. Sawai, C. M., V. Sisirak, H. S. Ghosh, E. Z. Hou, M. Ceribelli, L. M. Staudt, and B. Reizis. 2013. Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells. J. Exp. Med. 210: 2151-2159.
32. Swirski, F. K., M. Nahrendorf, M. Etzrodt, M. Wildgruber, V. Cortez-Retamozo, P. Panizzi, J. L. Figueiredo, R. H. Kohler, A. Chudnovskiy, P. Waterman, et al. 2009. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325: 612-616.
33. Chiossone, L., J. Chaix, N. Fuseri, C. Roth, E. Vivier, and T. Walzer. 2009. Maturation of mouse NK cells is a 4-stage developmental program. Blood 113:5488-5496.
34. Saederup, N., A. E. Cardona, K. Croft, M. Mizutani, A. C. Cotleur, C.-L. Tsou, R. M. Ransohoff, and I. F. Charo. 2010. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5: e13693.
35. Shi, C., T. Jia, S. Méndez-Ferrer, T. M. Hohl, N. V. Serbina, L. Lipuma, I. Leiner, M. O. Li, P. S. Frenette, and E. G. Pamer. 2011. Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating Toll-like receptor ligands. Immunity 34: 590-601.
36. Jung, S., J. Aliberti, P. Graemmel, M. J. Sunshine, G. W. Kreutzberg, A. Sher, and D. R. Littman. 2000. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20: 4106-4114. (Pubitemid 30314508)
37. Sunderkö tter, C., T. Nikolic, M. J. Dillon, N. Van Rooijen, M. Stehling, D. A. Drevets, and P. J. M. Leenen. 2004. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172: 4410-4417.
38. Tacke, F., and G. J. Randolph. 2006. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 211: 609-618.
39. Auffray, C., M. H. Sieweke, and F. Geissmann. 2009. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 27: 669-692.
40. Schlitzer, A., J. Loschko, K. Mair, R. Vogelmann, L. Henkel, H. Einwächter, M. Schiemann, J. H. Niess, W. Reindl, and A. Krug. 2011. Identification of CCR92 murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs. Blood 117: 6562-6570.
41. Schlitzer, A., A. F. Heiseke, H. Einwächter,W. Reindl,M. Schiemann, C.-P. Manta, P. See, J. H. Niess, T. Suter, F. Ginhoux, and A. B. Krug. 2012. Tissue-specific differentiation of a circulating CCR92 pDC-like common dendritic cell precursor. Blood 119: 6063-6071.
42. Björck, P., H. X. Leong, and E. G. Engleman. 2011. Plasmacytoid dendritic cell dichotomy: identification of IFN-a producing cells as a phenotypically and functionally distinct subset. J. Immunol. 186: 1477-1485.
43. Hadeiba, H., T. Sato, A. Habtezion, C. Oderup, J. Pan, and E. C. Butcher. 2008. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat. Immunol. 9: 1253-1260.
44. Sánchez-Alcañ iz, J. A., S. Haege, W. Mueller, R. Pla, F. Mackay, S. Schulz, G. López-Bendito, R. Stumm, and O. Marín. 2011. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 69: 77-90.
45. Lee, K. M., C. S. McKimmie, D. S. Gilchrist, K. J. Pallas, R. J. Nibbs, P. Garside, V. McDonald, C. Jenkins, R. Ransohoff, L. Liu, et al. 2011. D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood 118: 6220-6229.
46. Charo, I. F., S. J. Myers, A. Herman, C. Franci, A. J. Connolly, and S. R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 91: 2752-2756. (Pubitemid 24139426)
47. Sohy, D., M. Parmentier, and J.-Y. Springael. 2007. Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J. Biol. Chem. 282: 30062-30069. (Pubitemid 350035295)
48. Sohy, D., H. Yano, P. de Nadai, E. Urizar, A. Guillabert, J. A. Javitch, M. Parmentier, and J.-Y. Springael. 2009. Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. J. Biol. Chem. 284: 31270-31279.
49. El-Asmar, L., J.-Y. Springael, S. Ballet, E. U. Andrieu, G. Vassart, and M. Parmentier. 2005. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol. Pharmacol. 67: 460-469. (Pubitemid 40216739)
50. Springael, J.-Y., P. N. Le Minh, E. Urizar, S. Costagliola, G. Vassart, and M. Parmentier. 2006. Allosteric modulation of binding properties between units of chemokine receptor homo- and hetero-oligomers. Mol. Pharmacol. 69: 1652-1661.
51. Schall, T. J., and A. E. I. Proudfoot. 2011. Overcoming hurdles in developing successful drugs targeting chemokine receptors. Nat. Rev. Immunol. 11: 355-363.